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    HYALURONIC ACID BASED HYDROGEL AND USE THEREOF IN SURGERY
    1.
    发明申请
    HYALURONIC ACID BASED HYDROGEL AND USE THEREOF IN SURGERY 有权
    基于羟丙酸的水凝胶及其在手术中的应用

    公开(公告)号：US20130129800A1

    公开(公告)日：2013-05-23

    申请号：US13813422

    申请日：2011-07-29

    申请人： Gaetano Giammona ,  Giovanna Pitarresi ,  Fabio Palumbo ,  Carlo Luca Romano' ,  Enzo Meani ,  Edgardo Cremascoli

    发明人： Gaetano Giammona ,  Giovanna Pitarresi ,  Fabio Palumbo ,  Carlo Luca Romano' ,  Enzo Meani ,  Edgardo Cremascoli

    IPC分类号： A61K47/36

    CPC分类号： A61K47/36 ,  A61L27/20 ,  A61L27/34 ,  A61L27/52 ,  A61L27/54 ,  A61L2300/258 ,  A61L2300/402 ,  A61L2300/414 ,  C08B37/0072 ,  C08J3/075 ,  C08J2305/08 ,  C08L5/08

    摘要： The present invention relates to hydrogels based on hyaluronic acid based derivatives, that are more resistant than hyaluronic acid alone towards chemical and enzymatic degradation and are endowed with a mix of chemical and mechanical properties such that they are of optimal use in several surgeries, for instance for injection in bone fractures or cavities and for the production of coatings of prostheses in orthopedic surgery, as fillers in cosmetic and maxillo-facial surgery, as anti-adhesion barrier in the prevention of postoperative adhesions in abdominal and abdominal/pelvic surgery, and in general surgery. These hydrogels can be loaded with several different kinds of compounds having pharmacological and biological activity, that are then released from the hydrogel in the site of intervention.

    摘要翻译： 本发明涉及基于透明质酸的衍生物的水凝胶，其比单独的透明质酸对化学和酶降解更具抗性，并且具有化学和机械性质的混合物，使得它们在几种手术中是最佳用途，例如 用于骨折或腔内注射和用于在整形外科手术中生产假体涂层，作为化妆品和上颌面手术中的填充剂，作为防止腹部和腹部/骨盆手术中术后粘连的抗粘连屏障，以及 一般手术。 这些水凝胶可以装载几种具有药理和生物活性的化合物，然后在介入部位从水凝胶中释放。