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公开(公告)号:US08715692B2
公开(公告)日:2014-05-06
申请号:US12633995
申请日:2009-12-09
申请人: Peter Pushko , Yingyun Wu , Michael Massare , Ye Liu , Gale Smith , Bin Zhou
发明人: Peter Pushko , Yingyun Wu , Michael Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: A61K39/155 , C07K14/135 , C12N15/40 , C12N5/10
CPC分类号: A61K39/155 , A61K9/0019 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12N2760/18571
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
摘要翻译: 本发明通常涉及修饰或突变的呼吸道合胞病毒融合(F)蛋白及其制备及使用方法,包括用于治疗和/或预防RSV感染的疫苗等免疫原性组合物。
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公开(公告)号:US20130122032A1
公开(公告)日:2013-05-16
申请号:US13629107
申请日:2012-09-27
申请人: Gale SMITH , Yingyun Wu , Michael Massare , Ye Liu
发明人: Gale SMITH , Yingyun Wu , Michael Massare , Ye Liu
IPC分类号: C07K14/135 , A61K39/155
CPC分类号: A61K39/155 , A61K39/12 , A61K2039/5258 , A61K2039/54 , A61K2039/55505 , A61K2039/55555 , C07K14/005 , C07K14/135 , C12N7/00 , C12N2760/18522 , C12N2760/18534
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
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公开(公告)号:US20100239617A1
公开(公告)日:2010-09-23
申请号:US12633995
申请日:2009-12-09
申请人: Peter PUSHKO , Yingyun Wu , Michael Massare , Ye Liu , Gale Smith , Bin Zhou
发明人: Peter PUSHKO , Yingyun Wu , Michael Massare , Ye Liu , Gale Smith , Bin Zhou
IPC分类号: A61K39/155 , C07K14/135 , C07H21/02 , C12N5/10 , C12N7/00 , A61K9/00 , A61P31/14
CPC分类号: A61K39/155 , A61K9/0019 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12N2760/18571
摘要: The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
摘要翻译: 本发明通常涉及修饰或突变的呼吸道合胞病毒融合(F)蛋白及其制备及使用方法,包括用于治疗和/或预防RSV感染的疫苗等免疫原性组合物。
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公开(公告)号:US09724405B2
公开(公告)日:2017-08-08
申请号:US13883745
申请日:2011-11-07
申请人: Gale Smith , Ye Liu
发明人: Gale Smith , Ye Liu
IPC分类号: A61K39/205 , C07K14/00 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号: A61K39/205 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C12N2760/20134 , C12N2799/026
摘要: The present invention is generally related to virus-like particles (VLPs) comprising rabies virus (RV) glycoproteins (G proteins) and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of rabies virus infection.
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公开(公告)号:US20140178419A1
公开(公告)日:2014-06-26
申请号:US13883745
申请日:2011-11-07
申请人: Gale Smith , Ye Liu
发明人: Gale Smith , Ye Liu
IPC分类号: A61K39/205 , C07K14/005
CPC分类号: A61K39/205 , A61K39/12 , A61K2039/5258 , A61K2039/55505 , C07K14/005 , C12N2760/20134 , C12N2799/026
摘要: The present invention is generally related to virus-like particles (VLPs) comprising rabies virus (RV) glycoproteins (G proteins) and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of rabies virus infection.
摘要翻译: 本发明通常涉及包含狂犬病病毒(RV)糖蛋白(G蛋白)的病毒样颗粒(VLP)以及用于制备和使用它们的方法,包括用于治疗和/或预防狂犬病病毒感染的疫苗的免疫原性组合物 。
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公开(公告)号:US08711906B2
公开(公告)日:2014-04-29
申请号:US12941217
申请日:2010-11-08
申请人: Mohammad Mobin , Ye Liu , Amaresh Malipatil
发明人: Mohammad Mobin , Ye Liu , Amaresh Malipatil
CPC分类号: H04L25/03012 , H04L2025/03439
摘要: In described embodiments, a transceiver includes an eye monitor and margin detector having one or more samplers with corresponding logic. One or more programmable provisioning parameters are defined based on a pre-defined minimum target operating margin for acceptable noise and jitter margins. For example, two programmable provisioning parameters, phase and voltage, correspond with thresholds for margin samplers placed within the eye. Initially, the transceiver applies equalization, after which an inner eye of the transceiver, as detected by the eye monitor, is relatively open with some margin for supporting channels. If the receiver margin goes below this target margin, the eye closes, which is registered by the samplers. In the presence of spectrally rich input data, if the receiver margin goes below this target margin, an updated adaptation of equalizer or other circuit parameters might be initiated; else, adaptation is not generally required.
摘要翻译: 在所描述的实施例中,收发器包括具有具有相应逻辑的一个或多个采样器的眼睛监视器和边缘检测器。 基于用于可接受的噪声和抖动余量的预定义的最小目标操作裕度来定义一个或多个可编程供应参数。 例如,两个可编程供应参数(相位和电压)对应于放置在眼睛内的余量采样器的阈值。 最初,收发机应用均衡,之后由眼睛监视器检测到的收发器的内眼相对开放,具有用于支持信道的一些余量。 如果接收机边缘低于该目标边距,则眼睛关闭,由采样器注册。 在存在频谱丰富的输入数据的情况下,如果接收器余量低于该目标余量,则可以启动更新的均衡器或其他电路参数的适配; 否则,通常不需要适应。
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7.
公开(公告)号:US08703194B2
公开(公告)日:2014-04-22
申请号:US11934638
申请日:2007-11-02
申请人: Ye Liu , Decheng Wu , Chaobin He
发明人: Ye Liu , Decheng Wu , Chaobin He
IPC分类号: A61K9/14
CPC分类号: A61K9/1075 , A61K9/06 , A61K47/34 , C08F120/10 , C08F120/54
摘要: There is presently provided a stimulus-responsive polymer comprising a biodegradable polymer backbone and a stimulus-responsive pendant group attached to the biodegradable polymer backbone, wherein the biodegradable polymer backbone comprises a poly(amino ester) or a poly(amido amine), the poly(amido amine) optionally comprising a disulfide linkage in the backbone.
摘要翻译: 目前提供了包含可生物降解的聚合物主链和连接到可生物降解的聚合物主链的刺激响应侧基的刺激响应性聚合物,其中生物可降解的聚合物主链包含聚(氨基酯)或聚(酰氨基胺),聚 (酰胺胺),其任选地在主链中包含二硫键。
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公开(公告)号:US08586827B2
公开(公告)日:2013-11-19
申请号:US12894655
申请日:2010-09-30
申请人: Lan Tang , Ye Liu , Junxin Duan , Wenping Wu , Randall Kramer
发明人: Lan Tang , Ye Liu , Junxin Duan , Wenping Wu , Randall Kramer
CPC分类号: C12P19/14 , C07K14/37 , C12N9/2437 , C12N15/8246 , C12P7/14 , C12P19/02
摘要: The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
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公开(公告)号:US08586346B2
公开(公告)日:2013-11-19
申请号:US13596879
申请日:2012-08-28
申请人: Ye Liu , Paul Harris , Lan Tang , Wenping Wu
发明人: Ye Liu , Paul Harris , Lan Tang , Wenping Wu
CPC分类号: C12N9/2437 , C12N1/22 , C12N15/1137 , C12N2310/14 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , C12Y302/01099 , Y02E50/16
摘要: The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
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公开(公告)号:US20130296444A1
公开(公告)日:2013-11-07
申请号:US13997179
申请日:2011-12-21
申请人: Decheng Wu , Ye Liu , Jianwei Xu , Chaobin He
发明人: Decheng Wu , Ye Liu , Jianwei Xu , Chaobin He
CPC分类号: A61K8/8152 , A61K47/32 , A61K2800/10 , A61K2800/48 , A61Q19/00 , C08F290/148
摘要: A copolymer for modifying rheology is formed of monomer units consisting essentially of at least one first monomer unit comprising a polyhedral oligomeric silsesquioxane having an ethylenically unsaturated radical; at least one second monomer unit comprising an unsaturated oligo-poly(dimethyl siloxane)(meth)acrylate; and a sufficient amount of at least one unsaturated water-soluble monomer, such that the copolymer is soluble in water. A composition may comprise an electrolyte and the copolymer. The rheology of an environment comprising an electrolyte may be modified by adding the copolymer to the environment.
摘要翻译: 用于改性流变学的共聚物由基本上由至少一种第一单体单元组成的单体形成,所述第一单体单元包含具有烯属不饱和基团的多面体低聚倍半硅氧烷; 包含不饱和低聚 - 聚(二甲基硅氧烷)(甲基)丙烯酸酯的至少一个第二单体单元; 和足够量的至少一种不饱和水溶性单体,使得共聚物可溶于水。 组合物可以包含电解质和共聚物。 包含电解质的环境的流变学可以通过将共聚物加入到环境中进行改性。
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