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    Antineoplastic Agents Targeted via Glut Transporters
    1.
    发明申请
    Antineoplastic Agents Targeted via Glut Transporters 审中-公开
    通过谷物转运蛋白靶向的抗肿瘤药物

    公开(公告)号：US20080269112A1

    公开(公告)日：2008-10-30

    申请号：US12027014

    申请日：2008-02-06

    申请人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    发明人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    IPC分类号： A61K38/16

    CPC分类号： A61K41/0071 ,  A61K41/0057 ,  A61K47/549 ,  A61K49/0036 ,  A61K49/0052 ,  C07H17/04

    摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neoplastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The inventions also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.

    摘要翻译： 本发明涉及通过GLUT运输系统特异性靶向肿瘤细胞的新型抗肿瘤剂和癌症诊断剂。 更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。 本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。 本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

    Antineoplastic agents targeted via glut transporters
    2.
    发明授权
    Antineoplastic agents targeted via glut transporters 有权
    通过谷氨酸转运蛋白靶向的抗肿瘤剂

    公开(公告)号：US07943586B2

    公开(公告)日：2011-05-17

    申请号：US10560075

    申请日：2004-06-09

    申请人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    发明人： Gang Zheng ,  Jerry D. Glickson ,  Britton Chance

    IPC分类号： C07G3/00 ,  C07G11/00 ,  C07H15/00 ,  C07H17/00 ,  C07H5/06 ,  A01N43/04 ,  A61K31/70

    CPC分类号： A61K41/0071 ,  A61K41/0057 ,  A61K47/549 ,  A61K49/0036 ,  A61K49/0052 ,  C07H17/04

    摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.

    摘要翻译： 本发明涉及通过GLUT运输系统特异性靶向新塑料细胞的新型抗肿瘤剂和癌症诊断剂。 更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。 本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。 本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

    Antineoplastic agents targeted via glut transporters
    4.
    发明申请
    Antineoplastic agents targeted via glut transporters 有权
    通过谷氨酸转运蛋白靶向的抗肿瘤剂

    公开(公告)号：US20060171893A1

    公开(公告)日：2006-08-03

    申请号：US10560075

    申请日：2004-06-09

    申请人： Gang Zheng ,  Jerry Glickson ,  Britton Chance

    发明人： Gang Zheng ,  Jerry Glickson ,  Britton Chance

    IPC分类号： A61K49/00 ,  C07H17/04 ,  A61K31/7052 ,  A61K31/704 ,  A61K31/337

    CPC分类号： A61K41/0071 ,  A61K41/0057 ,  A61K47/549 ,  A61K49/0036 ,  A61K49/0052 ,  C07H17/04

    摘要： The present invention relates to novel antineoplastic agents and cancer diagnostic agents that specifically target neo-plastic cells via the GLUT transportation system. More specifically, the invention relates to conjugates of 2-deoxyglucose, wherein a linker, which includes a covalent bond, is attached to 2-deoxyglucose at the 2 position, and the linker is attached to a therapeutic or diagnostic agent. The invention also relates to methods of treating tumor disease and methods of making the novel compounds of the present invention. The agents of the present invention are superior to previous agents as they are targeted via GLUT transporters.

    摘要翻译： 本发明涉及通过GLUT运输系统特异性靶向新塑料细胞的新型抗肿瘤剂和癌症诊断剂。 更具体地，本发明涉及2-脱氧葡萄糖的缀合物，其中包含共价键的接头在2位连接于2-脱氧葡萄糖，并且接头连接到治疗剂或诊断剂。 本发明还涉及治疗肿瘤疾病的方法和制备本发明新化合物的方法。 本发明的药剂优于先前的药剂，因为它们通过GLUT转运蛋白靶向。

    Examination and imaging of brain cognitive functions
    6.
    发明授权
    Examination and imaging of brain cognitive functions 有权
    大脑认知功能的检查和成像

    公开(公告)号：US07983741B2

    公开(公告)日：2011-07-19

    申请号：US12157185

    申请日：2008-06-07

    申请人： Britton Chance

    发明人： Britton Chance

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0059 ,  A61B5/0035 ,  A61B5/0042 ,  A61B5/6834

    摘要： A system and method for examining or imaging brain functions of a subject includes a light source and a light detector located on the exterior surface of the subject's head. The light source introduces transcranially optical radiation into the brain of a subject, and the light detector detects radiation that has migrated in a brain region from the light source to the detector. The system also provides brain stimulation and evaluates the detected radiation to determine a brain cognitive function of the subject. One embodiment of the system can detect a brain disorder. Another embodiment of the system can detect “deceit.” In addition to the optical module, the system may include other optional modules such as an EEG module, an MEG module, a thermography module, a respiratory module, a skin conductivity module, and a blood pressure module.

    摘要翻译： 用于检查或成像对象的脑功能的系统和方法包括位于受检者头部的外表面上的光源和光检测器。 光源将经射线的光辐射引入到受试者的脑中，并且光检测器检测已经在脑区域中从光源迁移到检测器的辐射。 该系统还提供脑刺激并评估检测到的辐射以确定受试者的脑认知功能。 该系统的一个实施例可以检测脑障碍。 该系统的另一实施例可以检测“欺骗”。除了光学模块之外，系统还可以包括其他可选模块，例如EEG模块，MEG模块，热成像模块，呼吸模块，皮肤电导率模块和 血压模块

    Detection, imaging and characterization of brain tissue
    7.
    发明申请
    Detection, imaging and characterization of brain tissue 审中-公开
    脑组织的检测，成像和表征

    公开(公告)号：US20100174160A1

    公开(公告)日：2010-07-08

    申请号：US12589636

    申请日：2009-10-26

    申请人： Britton Chance

    发明人： Britton Chance

    IPC分类号： A61B5/1455 ,  A61B6/00

    CPC分类号： A61B5/14553 ,  A61B5/0042 ,  A61B5/0073 ,  A61B5/4064 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/046

    摘要： An optical examination technique employs an optical system for in vivo non-invasive transcranial examination of brain tissue of a subject. The optical system includes an optical module arranged for placement on the exterior of the head, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation of the examined tissue. The processor is arranged to correlate the first and second data sets to detect abnormal tissue in the examined tissue.

    摘要翻译： 光学检查技术采用光学系统用于受试者脑组织的体内非侵入性经颅检查。 光学系统包括布置成放置在头部外部的光学模块，控制器和处理器。 光学模块包括位于选定几何图案中的光学输入端口和光学检测端口的阵列，以在生物组织内部提供多个光子迁移路径。 每个光学输入端口构造成将被检查的组织引入可见光或从光源发射的红外光。 每个光学检测端口被构造成将来自组织的光提供给光检测器。 控制器被构造和布置成激活一个或多个光源和光检测器，使得光检测器检测已经通过至少一个光子迁移路径迁移的光。 所述处理器接收对应于检测到的光的信号并形成至少两个数据集，所述数据集中的第一个表示所检查的组织区域中的血液体积，所述数据集中的第二个表示所检查的组织的血氧。 处理器被布置成使第一和第二数据集相关联，以检测检查的组织中的异常组织。

    Optical examination of biological tissue using non-contact irradiation and detection
    8.
    发明申请
    Optical examination of biological tissue using non-contact irradiation and detection 失效
    使用非接触式照射和检测对生物组织进行光学检查

    公开(公告)号：US20060058683A1

    公开(公告)日：2006-03-16

    申请号：US11203826

    申请日：2005-08-13

    申请人： Britton Chance

    发明人： Britton Chance

    IPC分类号： A61B5/05 ,  A61B6/00

    CPC分类号： A61B5/0059 ,  A61B5/0037 ,  A61B5/0068 ,  A61B5/0091 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4312 ,  A61B5/6834 ,  A61B5/7285

    摘要： An optical system for examination of biological tissue includes a light source, a light detector, optics and electronics. The light source generates a light beam, transmitted to the biological tissue, spaced apart from the source. The light detector is located away (i.e., in a non-contact position) from the examined biological tissue and is constructed to detect light that has migrated in the examined tissue. The electronics controls the light source and the light detector, and a system separates the reflected photons (e.g., directly reflected or scattered from the surface or superficial photons) from the photons that have migrated in the examined tissue. The system prevents detection of the “noise” photons by the light detector or, after detection, eliminates the “noise” photons in the detected optical data used for tissue examination.

    摘要翻译： 用于生物组织检查的光学系统包括光源，光检测器，光学器件和电子器件。 光源产生一个光束，传输到生物组织，与光源隔开。 光检测器位于被检查的生物组织的远离（即处于非接触位置）的位置，并被构造成检测在被检查的组织中迁移的光。 电子装置控制光源和光检测器，并且系统将已反射的光子（例如，从表面或表面光子直接反射或散射）与已检查组织中迁移的光子分离。 该系统防止光检测器检测“噪声”光子，或者在检测之后，消除用于组织检查的检测到的光学数据中的“噪声”光子。

    Sensing and interactive drug delivery
    9.
    发明授权
    Sensing and interactive drug delivery 失效
    感应和互动药物递送

    公开(公告)号：US06949081B1

    公开(公告)日：2005-09-27

    申请号：US09383476

    申请日：1999-08-26

    申请人： Britton Chance

    发明人： Britton Chance

    IPC分类号： A61B5/00 ,  A61M31/00 ,  A61M37/00 ,  A61N1/08 ,  A61N1/30 ,  A61N1/32 ,  F04B53/00

    CPC分类号： A61N1/0428 ,  A61B5/0022 ,  A61B5/0059 ,  A61M37/00 ,  A61N1/08 ,  A61N1/30 ,  A61N1/327

    摘要： An interactive drug delivery system includes a drug delivery module, an optical probe, a local controller, and an optional central controller. The drug delivery module is constructed and arranged to deliver selected amounts of a drug into a subject. The optical probe is constructed and arranged to detect in a selected tissue region of the subject a manifestation caused by the delivered drug. The local controller is constructed and arranged to receive data from or transmit data to the optical probe and the drug delivery module. The local controller is arranged to correlate optical data, received from the optical probe, to selected data and provide signals to the drug delivery module for adjusting the amounts of the drug to be delivered into the subject.

    摘要翻译： 交互式药物递送系统包括药物递送模块，光学探针，本地控制器和可选的中央控制器。 药物递送模块被构造和布置成将选定量的药物递送到受试者中。 光学探针被构造和布置成在对象的选定组织区域中检测由递送的药物引起的表现。 本地控制器被构造和布置成从光学探针和药物传递模块接收数据或传输数据。 本地控制器被布置成将从光学探针接收的光学数据与所选择的数据相关联，并向药物递送模块提供信号，以调整要递送到受试者的药物的量。

    Detection, imaging and characterization of breast tumors
    10.
    发明申请
    Detection, imaging and characterization of breast tumors 失效
    乳腺肿瘤的检测，成像和表征

    公开(公告)号：US20050197583A1

    公开(公告)日：2005-09-08

    申请号：US10983371

    申请日：2004-11-08

    申请人： Britton Chance

    发明人： Britton Chance

    IPC分类号： G01N21/17 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  A61B10/00 ,  A61B6/00

    CPC分类号： A61B5/0091 ,  A61B5/0073 ,  A61B5/14552 ,  A61B5/4312 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/046

    摘要： An optical examination technique employs an optical system for in vivo non-invasive examination of breast tissue of a subject. The optical system includes an optical module, a controller and a processor. The optical module includes an array of optical input ports and optical detection ports located in a selected geometrical pattern to provide a multiplicity of photon migration paths inside the biological tissue. Each optical input port is constructed to introduce into the examined tissue visible or infrared light emitted from a light source. Each optical detection port is constructed to provide light from the tissue to a light detector. The controller is constructed and arranged to activate one or several light sources and light detectors so that the light detector detects light that has migrated over at least one of the photon migration paths. The processor receives signals corresponding to the detected light and forms at least two data sets, a first of said data sets representing blood volume in the examined tissue region and a second of said data sets representing blood oxygenation of the examined tissue. The processor is arranged to correlate the first and second data sets to detect abnormal tissue in the examined tissue.

    摘要翻译： 光学检查技术采用光学系统用于体内非侵入性检查受试者的乳腺组织。 光学系统包括光学模块，控制器和处理器。 光学模块包括位于选定几何图案中的光学输入端口和光学检测端口的阵列，以在生物组织内部提供多个光子迁移路径。 每个光学输入端口构造成将被检查的组织引入可见光或从光源发射的红外光。 每个光学检测端口被构造成将来自组织的光提供给光检测器。 控制器被构造和布置成激活一个或多个光源和光检测器，使得光检测器检测已经通过至少一个光子迁移路径迁移的光。 所述处理器接收对应于检测到的光的信号并形成至少两个数据集，所述数据集中的第一个表示所检查的组织区域中的血液体积，所述数据集中的第二个表示所检查的组织的血氧。 处理器被布置成使第一和第二数据集相关联，以检测检查的组织中的异常组织。