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公开(公告)号：US20050171061A1
公开(公告)日：2005-08-04
申请号：US10851769
申请日：2004-05-20
申请人： Garrick Smith , Gitte Mikkelsen , Kim Andersen , Daniel Greve , Thomas Ruhland , Stephen Wren
发明人： Garrick Smith , Gitte Mikkelsen , Kim Andersen , Daniel Greve , Thomas Ruhland , Stephen Wren
IPC分类号： C07D241/04 , A61K20060101 , A61K31/445 , A61K31/495 , A61K31/675 , A61P20060101 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/28 , C07D20060101 , C07D211/20 , C07D295/15
CPC分类号： C07D295/15
摘要： The invention provides compounds of the formula wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors.
摘要翻译： 本发明提供下式的化合物，其中取代基如本申请中所定义。 这些化合物是有价值的甘氨酸转运抑制剂。
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公开(公告)号：US07067501B2
公开(公告)日：2006-06-27
申请号：US10851769
申请日：2004-05-20
申请人： Garrick P. Smith , Gitte Mikkelsen , Kim Andersen , Daniel Greve , Thomas Ruhland , Stephen P. Wren
发明人： Garrick P. Smith , Gitte Mikkelsen , Kim Andersen , Daniel Greve , Thomas Ruhland , Stephen P. Wren
IPC分类号： A61K31/495 , C07D295/15
CPC分类号： C07D295/15
摘要： The invention provides compounds of the formula wherein the substituents are as defined in the application. The compounds are valuable glycine transport inhibitors.
摘要翻译： 本发明提供下式的化合物，其中取代基如本申请中所定义。 这些化合物是有价值的甘氨酸转运抑制剂。
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3.发明授权公开(公告)号：US06699864B2
公开(公告)日：2004-03-02
申请号：US10177261
申请日：2002-06-20
申请人： Thomas Ruhland , Christian Krog-Jensen , Mario Rottländer , Gitte Mikkelsen , Ejner Knud Moltzen , Kim Andersen
发明人： Thomas Ruhland , Christian Krog-Jensen , Mario Rottländer , Gitte Mikkelsen , Ejner Knud Moltzen , Kim Andersen
IPC分类号： A61K315377
CPC分类号： C07D405/12 , C07D209/14 , C07D471/04
摘要： The present invention provides compounds of the formula: wherein R1-R8, X, Y, Z, n and m are defined in the application. The compounds of the invention have affinity for the 5-HT1A receptor.
摘要翻译： 本发明提供下式的化合物：其中R 1 -R 8，X，Y，Z，n和m定义在本申请中。本发明化合物对5-HT 1A受体具有亲和力。
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公开(公告)号：US20070060574A1
公开(公告)日：2007-03-15
申请号：US11551188
申请日：2006-10-19
申请人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
IPC分类号： A61K31/551 , A61K31/496 , C07D241/04 , C07D243/08
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US20050014740A1
公开(公告)日：2005-01-20
申请号：US10488280
申请日：2002-10-02
申请人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
IPC分类号： A61K31/4418 , A61K31/451 , A61K31/495 , A61K31/551 , A61P25/00 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D211/20 , C07D211/24 , C07D211/70 , C07D241/04 , C07D243/08 , C07D295/08 , C07D295/096 , A61K31/55 , A61K31/445
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译： 本发明提供由通式I表示的化合物，其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍，包括抑郁症，焦虑症，包括一般焦虑症，惊恐障碍和强迫症。
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公开(公告)号：US20060089368A1
公开(公告)日：2006-04-27
申请号：US11296836
申请日：2005-12-06
申请人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
IPC分类号： A61K31/495 , A61K31/445 , C07D241/04
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号：US20060084662A1
公开(公告)日：2006-04-20
申请号：US11296835
申请日：2005-12-06
申请人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
发明人： Thomas Ruhland , Garrick Smith , Benny Bang-Andersen , Ask Puschl , Ejner Moltzen , Kim Andersen
IPC分类号： A61K31/551 , A61K31/495 , A61K31/445 , C07D241/04 , C07D243/08 , C07D211/20
CPC分类号： C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要： The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号：US07393845B2
公开(公告)日：2008-07-01
申请号：US11758511
申请日：2007-06-05
申请人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottländer , Ejner Knud Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/536 , A61K31/496 , C07D405/12 , C07D413/12
CPC分类号： C07D401/12 , C07D405/12 , C07D409/14 , C07D413/12
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis
摘要翻译： 具有式（I）的杂芳基衍生物。 本发明的化合物被认为可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社会恐惧症和进食障碍，以及神经系统疾病如精神病
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公开(公告)号：US20080027071A1
公开(公告)日：2008-01-31
申请号：US11758511
申请日：2007-06-05
申请人： Mario Rottlander , Ejner Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
发明人： Mario Rottlander , Ejner Moltzen , Ivan Mikkelsen , Thomas Ruhland , Kim Andersen , Christian Krog-Jensen
IPC分类号： A61K31/496 , A61K31/506 , A61P25/00 , C07D401/14 , C07D403/14 , C07D405/14
CPC分类号： C07D401/12 , C07D405/12 , C07D409/14 , C07D413/12
摘要： A heteroaryl derivative having the formula (I). The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis.
摘要翻译： 具有式（I）的杂芳基衍生物。 认为本发明的化合物可用于治疗情绪障碍，例如一般性焦虑障碍，恐慌症，强迫症，抑郁症，社交恐惧症和进食障碍以及神经障碍如精神病。
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10.发明申请Dosing form for a polymer support, use of said dosing form in organic chemical synthesis and method for production of said dosing form 审中-公开用于聚合物载体的剂量形式，在有机化学合成中使用所述加料形式以及用于生产所述加料形式的方法公开(公告)号：US20050130228A1
公开(公告)日：2005-06-16
申请号：US10965662
申请日：2004-10-14
申请人： Thomas Ruhland , Per Holm , Kirsten Schultz , Jannie Holm , Kim Andersen
发明人： Thomas Ruhland , Per Holm , Kirsten Schultz , Jannie Holm , Kim Andersen
IPC分类号： C07B61/00 , B01J19/00 , C07B63/00 , C07C211/27 , C07C211/35 , C07C217/60 , C07K1/04 , C08L101/00 , C40B60/14 , G01N33/53 , G01N33/543
CPC分类号： C07K1/042 , B01J19/0046 , B01J2219/00351 , B01J2219/00459 , B01J2219/00497 , B01J2219/005 , B01J2219/00585 , B01J2219/0059 , B01J2219/00592 , B01J2219/0072 , C07B2200/11 , C40B60/14
摘要： A dosing form for a polymer support for organic chemical synthesis in a solvent medium comprising a fixed weight amount of beads of a polymer containing functional groups, which polymer is insoluble in the solvent for the intended synthesis, is provided as compressed tablets of essentially equal weight and composition wherein the polymer beads are essentially intact and are released as such when the tablets are disintegrated in said solvent. Use of the dosing form is made in conventional synthesis, in parallel synthesis, in split and mix synthesis and/or combinatorial chemistry. In a method for producing the dosing form, beads of a polymer having functional gropusgroups is compressed into tablets after pre-treatment with an aprotic organic solvent. groups are compressed into tablets after pre-treatment with an aprotic organic solvent.
摘要翻译： 提供用于溶剂介质中有机化学合成的聚合物载体的剂型，其包含固定重量的含有官能团的聚合物珠，该聚合物不溶于用于预期合成的溶剂中，作为基本相等重量的压片 和组合物，其中当片剂在所述溶剂中崩解时，聚合物珠基本上是完整的并且如此释放。 在分批和混合合成和/或组合化学中，在常规合成，并行合成中使用配料形式。 在制备给药形式的方法中，具有功能性组蛋白的聚合物的珠粒在用非质子有机溶剂预处理后被压缩成片剂。 在用非质子有机溶剂预处理后，将组压缩成片剂。
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