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公开(公告)号：US20080221011A1
公开(公告)日：2008-09-11
申请号：US11821370
申请日：2007-06-21
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/70596 , C07K2319/00
摘要： The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.
摘要翻译： 本发明提供包含CR2部分的CR2-FH分子，其包含CR2蛋白或其片段和包含因子H蛋白或其片段的FH部分和包含CR2-FH分子的药物组合物。 还提供了使用组合物治疗涉及替代补体途径的疾病的方法，例如年龄相关性黄斑变性，类风湿性关节炎和缺血再灌注。
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公开(公告)号：US08569225B2
公开(公告)日：2013-10-29
申请号：US12782526
申请日：2010-05-18
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/70596 , C07K2319/00
摘要： The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.
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公开(公告)号：US07759304B2
公开(公告)日：2010-07-20
申请号：US11821370
申请日：2007-06-21
IPC分类号： C07K14/00
CPC分类号： C07K14/705 , A61K38/00 , C07K14/47 , C07K14/70596 , C07K2319/00
摘要： The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.
摘要翻译： 本发明提供包含CR2部分的CR2-FH分子，其包含CR2蛋白或其片段和包含因子H蛋白或其片段的FH部分和包含CR2-FH分子的药物组合物。 还提供了使用组合物治疗涉及替代补体途径的疾病的方法，例如年龄相关性黄斑变性，类风湿性关节炎和缺血再灌注。
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公开(公告)号：US08703140B2
公开(公告)日：2014-04-22
申请号：US11843617
申请日：2007-08-22
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/18 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/544 , C07K2317/34 , C07K2317/76 , C07K2319/30
摘要： Disclosed are novel inhibitors of the alternative complement pathway and particularly, novel anti-factor B antibodies. Also disclosed is the use of such inhibitors to reduce or prevent airway hyperresponsiveness and/or airway inflammation by selectively inhibiting the alternative complement pathway, thereby treating diseases in which such conditions play a role. Also disclosed is the use of such inhibitors to reduce or prevent other diseases and conditions, including ischemia-reperfusion injury, by inhibition of the alternative complement pathway.
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公开(公告)号：US08540997B2
公开(公告)日：2013-09-24
申请号：US13162434
申请日：2011-06-16
IPC分类号： A61K39/00
CPC分类号： C07K14/70596 , A61K38/00 , C07K14/705 , C07K16/2896 , C07K2319/00
摘要： Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.
摘要翻译： 补体系统的调节代表了与补体激活相关的许多病理状况的治疗方式。 在制备靶向补体活化和疾病部位的补体抑制剂的策略中，公开了包含与补体受体（CR）2连接的补体抑制剂的组合物。 所公开的是组合物可以用于通过调节补体系统来治疗病原性疾病和炎性病症的方法。
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公开(公告)号：US08007804B2
公开(公告)日：2011-08-30
申请号：US10534772
申请日：2003-11-13
CPC分类号： C07K14/70596 , A61K38/00 , C07K14/705 , C07K16/2896 , C07K2319/00
摘要： Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.
摘要翻译： 补体系统的调节代表了与补体激活相关的许多病理状况的治疗方式。 在制备靶向补体活化和疾病部位的补体抑制剂的策略中，公开了包含与补体受体（CR）2连接的补体抑制剂的组合物。 所公开的是组合物可以用于通过调节补体系统来治疗病原性疾病和炎性病症的方法。
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公开(公告)号：US09815890B2
公开(公告)日：2017-11-14
申请号：US13805522
申请日：2011-06-22
IPC分类号： C07K16/28 , A61K39/395 , C07K16/18 , C07K14/47
CPC分类号： C07K16/18 , C07K14/472 , C07K2317/33 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： The present invention relates to methods and materials for modulating the complement alternative pathway (CAP), the complement classical pathway (CCP), the complement lectin/mannose pathway (CMP), or combinations thereof, as well as methods and materials for targeting diagnostic, prophylactic and therapeutic agents to localized areas of tissue within the body where they may more directly exert their effects upon the intended target cells or tissue, with reduced, associated systemic effects compared with administration of the same or similar agents in an untargeted, systemic manner. The methods and materials of the present invention may therefore allow for increased efficacy, lower threshold effective dosages and/or lower effective maintenance doses, and/or reduced associated undesired or adverse effects in terms of frequency or severity of occurrence, or both. The present invention also relates to methods and materials for modulating a host humoral immune response, especially reducing, inhibiting, or preventing a host humoral immune response.
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公开(公告)号：US20120014952A1
公开(公告)日：2012-01-19
申请号：US13162479
申请日：2011-06-16
IPC分类号： A61K39/395 , C07K14/705 , A61K38/17 , A61P29/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P35/00 , C07K19/00 , A61P31/12
CPC分类号： C07K14/70596 , A61K38/00 , C07K14/705 , C07K16/2896 , C07K2319/00
摘要： Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.
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公开(公告)号：US20120015871A1
公开(公告)日：2012-01-19
申请号：US13162423
申请日：2011-06-16
CPC分类号： C07K14/70596 , A61K38/00 , C07K14/705 , C07K16/2896 , C07K2319/00
摘要： Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.
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公开(公告)号：US20120015872A1
公开(公告)日：2012-01-19
申请号：US13162434
申请日：2011-06-16
CPC分类号： C07K14/70596 , A61K38/00 , C07K14/705 , C07K16/2896 , C07K2319/00
摘要： Modulation of the complement system represents a therapeutic modality for numerous pathologic conditions associated with complement activation. In a strategy to prepare complement inhibitors that are targeted to sites of complement activation and disease, compositions comprising a complement inhibitor linked to complement receptor (CR) 2 are disclosed. The disclosed are compositions can be used in methods of treating pathogenic diseases and inflammatory conditions by modulating the complement system.
摘要翻译： 补体系统的调节代表了与补体激活相关的许多病理状况的治疗方式。 在制备靶向补体活化和疾病部位的补体抑制剂的策略中，公开了包含与补体受体（CR）2连接的补体抑制剂的组合物。 所公开的是组合物可以用于通过调节补体系统来治疗病原性疾病和炎性病症的方法。
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