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1.发明授权Method for inducing a multiclade immune response against HIV utilizing a multigene and multiclade immunogen 失效使用多基因和多重免疫原诱导针对HIV的多重免疫应答的方法公开(公告)号：US08454972B2
公开(公告)日：2013-06-04
申请号：US13010141
申请日：2011-01-20
申请人： Gary J. Nabel , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G. D. Gall , C. Richter King , Zengguang Wang
发明人： Gary J. Nabel , Yue Huang , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G. D. Gall , C. Richter King
IPC分类号： A61K39/21 , A61K39/295 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
摘要翻译： 本公开提供了针对人类免疫缺陷病毒引发免疫应答（包括预防性免疫应答）的组合物。 该组合物包括编码多个进化枝或菌株的HIV抗原多肽的核酸构建体。 还提供了通过将受试者施用组合物引起免疫应答的方法。
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2.发明申请公开(公告)号：US20090214588A1
公开(公告)日：2009-08-27
申请号：US11632522
申请日：2005-07-15
申请人： Gary J. Nabel , Yue Huang , Zengguang Wang , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G.D. Gall , C. Richter King
发明人： Gary J. Nabel , Yue Huang , Zengguang Wang , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G.D. Gall , C. Richter King
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
摘要翻译： 本公开提供了针对人类免疫缺陷病毒引发免疫应答（包括预防性免疫应答）的组合物。 该组合物包括编码多个进化枝或菌株的HIV抗原多肽的核酸构建体。 还提供了通过将受试者施用组合物引起免疫应答的方法。
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3.发明申请METHOD FOR IMPROVING THE BREADTH OF THE IMMUNE RESPONSE TO DIVERSE STRAINS AND CLADES OF HIV 失效改善免疫应答对多样性病毒和艾滋病病毒分布的方法公开(公告)号：US20110200636A1
公开(公告)日：2011-08-18
申请号：US13010141
申请日：2011-01-20
申请人： Gary J. Nabel , Yue Huang , Zengguang Wang , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G.D. Gall , C. Richter King
发明人： Gary J. Nabel , Yue Huang , Zengguang Wang , Ling Xu , Bimal Chakrabarti , Lan Wu , Zhi-yong Yang , Jason G.D. Gall , C. Richter King
CPC分类号： A61K39/21 , A61K39/00 , A61K39/12 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/57 , A61K2039/70 , C07K14/005 , C12N2740/16122 , C12N2740/16134 , C12N2740/16171 , C12N2740/16222 , C12N2740/16234 , C12N2740/16271 , C12N2740/16322 , C12N2740/16334 , C12N2740/16371
摘要： The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided.
摘要翻译： 本公开提供了针对人类免疫缺陷病毒引发免疫应答（包括预防性免疫应答）的组合物。 该组合物包括编码多个进化枝或菌株的HIV抗原多肽的核酸构建体。 还提供了通过将受试者施用组合物引起免疫应答的方法。
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公开(公告)号：US20100074916A1
公开(公告)日：2010-03-25
申请号：US12443964
申请日：2007-10-10
申请人： Gary J. Nabel , Zhi-yong Yang , Chih-jen Wei , Wing-pui Kong , Lan Wu
发明人： Gary J. Nabel , Zhi-yong Yang , Chih-jen Wei , Wing-pui Kong , Lan Wu
IPC分类号： A61K39/145 , C07K14/005 , C07K16/00 , C07H21/04 , C07H21/02 , C12P21/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , C07K14/005 , C12N2710/10343 , C12N2740/15043 , C12N2760/16122 , C12N2760/16134 , C12N2810/6072
摘要： H5 hemagglutinin (HA) polypeptides are provided that are adapted to humans through mutations that change receptor specificity in the H1 serotype, and related polynucleotides, methods, compositions, and vaccines.
摘要翻译： 提供H5血凝素（HA）多肽，其通过改变H1血清型中的受体特异性的突变以及相关的多核苷酸，方法，组合物和疫苗适应人类。
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公开(公告)号：US20120135215A1
公开(公告)日：2012-05-31
申请号：US12957151
申请日：2010-11-30
申请人： Kevin Paul McEvoy , Hrishikesh Keshavan , Anthony Yu-Chung Ku , Steven Mitchell Kuznicki , Weizhu An , Lan Wu , Paul Donald Swenson
发明人： Kevin Paul McEvoy , Hrishikesh Keshavan , Anthony Yu-Chung Ku , Steven Mitchell Kuznicki , Weizhu An , Lan Wu , Paul Donald Swenson
CPC分类号： C04B35/6303 , B01D67/0041 , B01D71/028 , B01D2323/08 , C04B35/117 , C04B35/19 , C04B35/195 , C04B35/6263 , C04B35/63416 , C04B2235/3217 , C04B2235/3218 , C04B2235/322 , C04B2235/3463 , C04B2235/5427 , C04B2235/5436 , C04B2235/5445
摘要： A free-standing zeolite membrane and a zeolite membrane supported on a support structure are disclosed. The free-standing zeolite membrane is fabricated by mixing zeolite particles and an optional inorganic binder, forming a green body, and sintering the green body at a sufficiently low temperature so as to prevent damage to the gas selectivity properties of the zeolite particles. The supported composite zeolite membrane is fabricated by mixing a sacrificial binder, an optional inorganic binder, boehmite sol and zeolite particles to form a slurry. The slurry is then coated onto a porous support structure, dried and sintered at a sufficiently low temperature so as to prevent damage to the gas selective properties of the zeolite particles. In both membranes, the zeolite particles span the entire thickness of the membrane to provide a high selectivity path for the flow of gas to pass therethrough.
摘要翻译： 公开了一种独立的沸石膜和支撑在支撑结构上的沸石膜。 独立沸石膜通过混合沸石颗粒和任选的无机粘合剂，形成生坯，并在足够低的温度下烧结生坯，以防止破坏沸石颗粒的气体选择性而制备。 负载的复合沸石膜通过混合牺牲粘合剂，任选的无机粘合剂，勃姆石溶胶和沸石颗粒以形成浆料来制备。 然后将浆料涂覆到多孔载体结构上，在足够低的温度下干燥和烧结，以防止损害沸石颗粒的气体选择性能。 在两个膜中，沸石颗粒跨越膜的整个厚度，以提供气体流过其中的高选择性路径。
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公开(公告)号：US08647997B2
公开(公告)日：2014-02-11
申请号：US12957151
申请日：2010-11-30
申请人： Kevin Paul McEvoy , Hrishikesh Keshavan , Anthony Yu-Chung Ku , Steven Mitchell Kuznicki , Weizhu An , Lan Wu , Paul Donald Swenson
发明人： Kevin Paul McEvoy , Hrishikesh Keshavan , Anthony Yu-Chung Ku , Steven Mitchell Kuznicki , Weizhu An , Lan Wu , Paul Donald Swenson
CPC分类号： C04B35/6303 , B01D67/0041 , B01D71/028 , B01D2323/08 , C04B35/117 , C04B35/19 , C04B35/195 , C04B35/6263 , C04B35/63416 , C04B2235/3217 , C04B2235/3218 , C04B2235/322 , C04B2235/3463 , C04B2235/5427 , C04B2235/5436 , C04B2235/5445
摘要： A free-standing zeolite membrane and a zeolite membrane supported on a support structure are disclosed. The free-standing zeolite membrane is fabricated by mixing zeolite particles and an optional inorganic binder, forming a green body, and sintering the green body at a sufficiently low temperature so as to prevent damage to the gas selectivity properties of the zeolite particles. The supported composite zeolite membrane is fabricated by mixing a sacrificial binder, an optional inorganic binder, boehmite sol and zeolite particles to form a slurry. The slurry is then coated onto a porous support structure, dried and sintered at a sufficiently low temperature so as to prevent damage to the gas selective properties of the zeolite particles. In both membranes, the zeolite particles span the entire thickness of the membrane to provide a high selectivity path for the flow of gas to pass therethrough.
摘要翻译： 公开了一种独立的沸石膜和支撑在支撑结构上的沸石膜。 独立沸石膜通过混合沸石颗粒和任选的无机粘合剂，形成生坯，并在足够低的温度下烧结生坯，以防止破坏沸石颗粒的气体选择性而制备。 负载的复合沸石膜通过混合牺牲粘合剂，任选的无机粘合剂，勃姆石溶胶和沸石颗粒以形成浆料来制备。 然后将浆料涂覆到多孔载体结构上，在足够低的温度下干燥和烧结，以防止损害沸石颗粒的气体选择性能。 在两个膜中，沸石颗粒跨越膜的整个厚度，以提供气体流过其中的高选择性路径。
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