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1.发明授权公开(公告)号：US08471001B2
公开(公告)日：2013-06-25
申请号：US13287228
申请日：2011-11-02
CPC分类号： A61K8/60 , A23K20/158 , A23L33/115 , A61Q19/00
摘要： It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
摘要翻译： 已经发现，鲎阳性糖脂存在于源自黄单胞菌属的黄原胶中，黄原胶已经可商购并食用多年，并且这被纯化，并且已经发现这种鲎阳性糖脂具有免疫增强效应 。 提供了一种安全廉价地生产含有高浓度免疫增强剂的鲎阳性糖脂的方法。 本发明的鲎阳性糖脂的制造方法包括从黄原胶中提取鲎阳性糖脂。 含有鲎阳性糖脂的鲎阳性糖脂组合物可用于各种用途，例如药物，动物药物，准药物，化妆品，食品，功能性食品，饲料和浴剂。
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2.发明申请Method for Fermentation and Culture, Fermented Plant Extract, Fermented Plant Extract Composition, Method for Producing Lipopolysaccharide and Lipopolysaccharide 有权发酵培养方法，发酵植物提取物，发酵植物提取物组成，生产脂多糖和脂多糖的方法公开(公告)号：US20090162344A1
公开(公告)日：2009-06-25
申请号：US12085549
申请日：2006-11-28
CPC分类号： C12N1/20 , A23G3/48 , A23L33/10 , A23L33/105 , A61K36/03 , A61K36/48 , A61K36/899 , C12P19/04
摘要： In order to provide a method for culturing an immunopotentiator-containing organism having the experience of being eaten, inexpensively without requiring usage of a component derived from an animal, Acetobacter, Gluconobacter, Xanthomonas, Zymomonas or Enterobacter which is an edible gram-negative bacterium having an immunopotentiation function is cultured using a culture solution composed mainly of wheat or bean curd refuse. Thereby, Acetobacter can be obtained inexpensively and safely, and also a low molecular weight lipopolysaccharide which is the immunopotentiator can be obtained inexpensively and safely. Furthermore, no impurity derived from animal components is mixed.
摘要翻译： 为了提供一种培养具有食用经验的免疫增强剂生物体的方法，不需要使用源自动物，醋杆菌，葡萄糖杆菌，黄单胞菌属，发酵单胞菌属或肠杆菌的成分，其是可食用的革兰氏阴性细菌，其具有 使用主要由小麦或豆腐垃圾组成的培养液培养免疫增强功能。 由此，可以廉价且安全地获得醋杆菌，并且可以廉价且安全地获得作为免疫增强剂的低分子量脂多糖。 此外，没有混合从动物成分得到的杂质。
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3.发明申请公开(公告)号：US20120046459A1
公开(公告)日：2012-02-23
申请号：US13287228
申请日：2011-11-02
IPC分类号： C08B37/00
CPC分类号： A61K8/60 , A23K20/158 , A23L33/115 , A61Q19/00
摘要： It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
摘要翻译： 已经发现，鲎阳性糖脂存在于源自黄单胞菌属的黄原胶中，黄原胶已经可商购并食用多年，并且这被纯化，并且已经发现这种鲎阳性糖脂具有免疫增强效应 。 提供了一种安全廉价地生产含有高浓度免疫增强剂的鲎阳性糖脂的方法。 本发明的鲎阳性糖脂的制造方法包括从黄原胶中提取鲎阳性糖脂。 含有鲎阳性糖脂的鲎阳性糖脂组合物可用于各种用途，例如药物，动物药物，准药物，化妆品，食品，功能性食品，饲料和浴剂。
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4.发明授权公开(公告)号：US07485698B2
公开(公告)日：2009-02-03
申请号：US11413751
申请日：2006-04-28
CPC分类号： C07K14/525 , A61K38/00
摘要： An object of the present invention is to provide a novel malignant glioma antitumor agent and malignant glioma antitumor agent for animals, and in order to achieve this object, in the present invention a polypeptide indicated by the following (a) or (b), or a mixture thereof, is contained in a malignant glioma antitumor agent: (a) a polypeptide comprising the amino acid sequence represented by SEQ. ID NO. 1 or SEQ. ID NO. 2; or (b) a polypeptide comprising the amino acid sequence represented by SEQ. ID NO. 1 or SEQ. ID NO. 2 with 1 or more amino acids deleted, substituted or added, and which has malignant glioma antitumor action.
摘要翻译： 本发明的目的是提供一种用于动物的新型恶性神经胶质瘤抗肿瘤剂和恶性胶质瘤抗肿瘤剂，为了实现该目的，在本发明中，由以下（a）或（b）表示的多肽或 其混合物包含在恶性胶质瘤抗肿瘤剂中：（a）包含SEQ ID NO：1所示的氨基酸序列的多肽。 证件号码。 1或SEQ。 证件号码。 2; 或（b）包含SEQ ID NO：1所示的氨基酸序列的多肽。 证件号码。 1或SEQ。 证件号码。 2具有1个或多个氨基酸缺失，取代或添加，并具有恶性胶质瘤抗肿瘤作用。
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5.发明申请公开(公告)号：US20070059279A1
公开(公告)日：2007-03-15
申请号：US11413751
申请日：2006-04-28
IPC分类号： A61K38/19
CPC分类号： C07K14/525 , A61K38/00
摘要： An object of the present invention is to provide a novel malignant glioma antitumor agent and malignant glioma antitumor agent for animals, and in order to achieve this object, in the present invention a polypeptide indicated by the following (a) or (b), or a mixture thereof, is contained in a malignant glioma antitumor agent: (a) a polypeptide comprising the amino acid sequence represented by SEQ. ID NO. 1 or SEQ. ID NO. 2; or (b) a polypeptide comprising the amino acid sequence represented by SEQ. ID NO. 1 or SEQ. ID NO. 2 with 1 or more amino acids deleted, substituted or added, and which has malignant glioma antitumor action.
摘要翻译： 本发明的目的是提供一种用于动物的新型恶性神经胶质瘤抗肿瘤剂和恶性胶质瘤抗肿瘤剂，为了实现该目的，在本发明中，由以下（a）或（b）表示的多肽或 其混合物包含在恶性胶质瘤抗肿瘤剂中：（a）包含SEQ ID NO：1所示的氨基酸序列的多肽。 证件号码。 1或SEQ。 证件号码。 2; 或（b）包含SEQ ID NO：1所示氨基酸序列的多肽。 证件号码。 1或SEQ。 证件号码。 2具有1个或更多个氨基酸缺失，取代或添加，并且具有恶性胶质瘤抗肿瘤作用。
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公开(公告)号：US20140194287A1
公开(公告)日：2014-07-10
申请号：US14126154
申请日：2012-06-14
申请人： Gen-Ichiro Soma , Hiroyuki Inagawa , Chie Kohchi
发明人： Gen-Ichiro Soma , Hiroyuki Inagawa , Chie Kohchi
CPC分类号： C12N1/066 , A01N63/02 , A23K10/16 , A23K20/00 , A23K20/10 , A23K40/10 , A23K50/40 , A23L33/10 , A23L33/135 , A23V2002/00 , A61K8/99 , A61K35/74 , A61K39/39 , A61K2800/10 , A61K2800/70 , A61Q19/00 , C05F11/00 , C07K14/472 , C12N1/20
摘要： A crushed bacterial body can be obtained by culturing a gram-negative bacterium and physically crushing a body of the gram-negative bacterium, comprises all components including immunostimulatory components in the bacterial body, and comprises LPSs having molecular weights of 20,000 or less as active ingredients. The crushed bacterial body is effective as a health food, drug, skin-care product, bath agent, feedstuff for protecting crustaceans, shellfish, fish, poultry, farm animals and pet animals from infections, and a feed additive for growth promotion, and can provide an innate immunostimulatory substance derived from a gram-negative bacterial body having infection-preventing effects and growth promoting effects, an inexpensive and practical microbial crushed bacterial body, and a composition thereof.
摘要翻译： 通过培养革兰氏阴性细菌并物理地破碎革兰氏阴性细菌的体内，可以获得破碎的细菌体，其包括细菌体中包含免疫刺激成分的所有成分，并且包含分子量为20,000以下的LPS作为活性成分 。 破碎的细菌体作为保健食品，药物，护肤品，浴剂，用于保护甲壳类动物，贝类，鱼类，禽类，农场动物和感染宠物的饲料以及促进生长的饲料添加剂是有效的，并且可以 提供具有感染预防作用和生长促进作用的革兰氏阴性菌体的廉价免疫刺激物质，廉价实用的微生物破碎细菌体及其组合物。
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7.发明授权Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder, and composition containing the extract of fermented plant 有权发酵和培养方法，发酵植物提取物，发酵植物提取物粉末和含有发酵植物提取物的组合物公开(公告)号：US08075928B2
公开(公告)日：2011-12-13
申请号：US10572853
申请日：2004-09-22
CPC分类号： C12N1/20 , A23L7/104 , A23L11/09 , A23L33/105 , A23V2002/00 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04 , Y02P60/877 , A23V2200/324 , A23V2250/21
摘要： For the purpose of providing a method of safely and inexpensively producing a fermented plant extract containing an immunopotentiator at a high concentration, the method for fermentation and culture of the present invention ferments a plant component such as wheat flour using Pantoea agglomerans which is a gram negative bacterium which lives in a symbiotic relationship with a plant such as wheat and apple. It becomes possible to remarkably augment an immunopotentiation action which the plant has. In addition, these are not contaminated with impurities derived from animal components, and thus these are highly safe.
摘要翻译： 为了提供一种安全廉价地生产含有高浓度免疫增强剂的发酵植物提取物的方法，本发明的发酵和培养方法使用成团革兰氏酵母（Pantoea） 与小麦和苹果等植物共生关系的细菌。 可以显着增加植物具有的免疫增强作用。 此外，这些不会被来自动物成分的杂质污染，因此这些是高度安全的。
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8.发明授权Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder, and composition containing the extract of fermented plant 有权发酵和培养方法，发酵植物提取物，发酵植物提取物粉末和含有发酵植物提取物的组合物公开(公告)号：US09394513B2
公开(公告)日：2016-07-19
申请号：US13296551
申请日：2011-11-15
IPC分类号： A61K36/00 , C12N1/20 , A23L1/105 , A23L1/20 , A23L1/30 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04
CPC分类号： C12N1/20 , A23L7/104 , A23L11/09 , A23L33/105 , A23V2002/00 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04 , Y02P60/877 , A23V2200/324 , A23V2250/21
摘要： For the purpose of providing a method of safely and inexpensively producing a fermented plant extract containing an immunopotentiator at a high concentration, the method for fermentation and culture of the present invention ferments a plant component such as wheat flour using Pantoea agglomerans which is a gram negative bacterium which lives in a symbiotic relationship with a plant such as wheat and apple. It becomes possible to remarkably augment an immunopotentiation action which the plant has. In addition, these are not contaminated with impurities derived from animal components, and thus these are highly safe.
摘要翻译： 为了提供一种安全廉价地生产含有高浓度免疫增强剂的发酵植物提取物的方法，本发明的发酵和培养方法使用成团革兰氏酵母（Pantoea） 与小麦和苹果等植物共生关系的细菌。 可以显着增加植物具有的免疫增强作用。 此外，这些不会被来自动物成分的杂质污染，因此这些是高度安全的。
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9.发明授权公开(公告)号：US08071758B2
公开(公告)日：2011-12-06
申请号：US12308997
申请日：2007-02-28
CPC分类号： A61K8/60 , A23K20/158 , A23L33/115 , A61Q19/00
摘要： It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
摘要翻译： 已经发现，鲎阳性糖脂存在于源自黄单胞菌属的黄原胶中，黄原胶已经可商购并食用多年，并且这被纯化，并且已经发现这种鲎阳性糖脂具有免疫增强效应 。 提供了一种安全廉价地生产含有高浓度免疫增强剂的鲎阳性糖脂的方法。 本发明的鲎阳性糖脂的制造方法包括从黄原胶中提取鲎阳性糖脂。 含有鲎阳性糖脂的鲎阳性糖脂组合物可用于各种用途，例如药物，动物药物，准药物，化妆品，食品，功能性食品，饲料和浴剂。
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10.发明申请Method for fermentation and cultivation, fermented plant extract, fermented plant extract powder, and composition containing the extract of fermented plant 有权发酵和培养方法，发酵植物提取物，发酵植物提取物粉末和含有发酵植物提取物的组合物公开(公告)号：US20070172492A1
公开(公告)日：2007-07-26
申请号：US10572853
申请日：2004-09-22
CPC分类号： C12N1/20 , A23L7/104 , A23L11/09 , A23L33/105 , A23V2002/00 , A61K36/03 , A61K36/48 , A61K36/88 , A61K36/899 , C12P1/04 , C12P19/04 , Y02P60/877 , A23V2200/324 , A23V2250/21
摘要： For the purpose of providing a method of safely and inexpensively producing a fermented plant extract containing an immunopotentiator at a high concentration, the method for fermentation and culture of the present invention ferments a plant component such as wheat flour using Pantoea agglomerans which is a gram negative bacterium which lives in a symbiotic relationship with a plant such as wheat and apple. It becomes possible to remarkably augment an immunopotentiation action which the plant has. In addition, these are not contaminated with impurities derived from animal components, and thus these are highly safe.
摘要翻译： 为了提供一种安全廉价地生产含有高浓度免疫增强剂的发酵植物提取物的方法，本发明的发酵和培养方法使用成团革兰氏酵母（Pantoea） 与小麦和苹果等植物共生关系的细菌。 可以显着增加植物具有的免疫增强作用。 此外，这些不会被来自动物成分的杂质污染，因此这些是高度安全的。
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