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公开(公告)号：US09670533B2
公开(公告)日：2017-06-06
申请号：US14187806
申请日：2014-02-24
申请人： Genisphere, LLC
发明人： Robert C. Getts , James Kadushin , Jessica Bowers
CPC分类号： C12Q1/6837 , C12Q1/682 , C40B30/04 , C12Q2525/313 , C12Q2525/173 , C12Q2521/501 , C12Q2565/102 , C12Q2525/207 , C12Q2525/119 , C12Q2537/162 , C12Q2565/501
摘要： Methods, reagents and kits are provided for the production and use in detection assays of labeled nucleic acid molecules wherein a labeling molecule is attached directly to the 3′ end of the nucleic acid molecules.
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公开(公告)号：US20170209599A1
公开(公告)日：2017-07-27
申请号：US15454612
申请日：2017-03-09
发明人： Robert C. Getts , Janet Sawicki
CPC分类号： A61K48/0058 , A61K9/0014 , A61K38/45 , A61K47/10 , A61K47/36 , A61K47/64 , A61K47/6829 , A61K47/6849 , A61K48/0041 , A61K48/0075 , C07K14/43595 , C12N9/1077 , C12N15/87 , C12Q1/6897 , C12Q1/708 , C12Y204/02036 , G01N33/5091 , G01N2333/025 , C12Q2525/313
摘要： Compositions are disclosed which comprise a DNA dendrimer having one or more DNA sequences linked thereto, the DNA sequences comprising DNA sequences encoding a polypeptide or regulatory RNA linked to DNA sequences that regulate expression of the DNA sequences encoding a polypeptide or regulatory RNA to produce an RNA coding for the polypeptide or to produce the regulatory RNA. Also disclosed are methods for treating diseases and conditions of cells by delivering the dendrimers to the cells, with subsequent expression of the encoded polypeptide or regulatory RNA.
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公开(公告)号：US20160051693A1
公开(公告)日：2016-02-25
申请号：US14778716
申请日：2014-03-19
申请人： GENISPHERE, LLC
发明人： Robert C. Getts , James Kadushin , Mindy George-Weinstein , Jacquelyn Gerhart , Emanuela Dylgjeri , Kelly Rhodes
IPC分类号： A61K47/48 , A61K31/704 , C07K16/28
CPC分类号： C07K16/28 , A61K31/704 , A61K47/549 , A61K47/62 , A61K47/6849 , A61K47/6859 , Y02A50/411
摘要： Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.
摘要翻译： 提供了将活性剂靶向递送至细胞的组合物和方法。 组合物包含全部或部分双链合成DNA载体和插入DNA载体双链部分的活性剂。 DNA载体也可以连接到靶向剂上。 所述组合物可用于将活性剂递送至靶细胞类型，例如细胞毒性剂。
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公开(公告)号：US20150177235A1
公开(公告)日：2015-06-25
申请号：US14414699
申请日：2013-07-12
申请人： Genisphere, LLC
IPC分类号： G01N33/548 , G01N33/76 , G01N33/558
CPC分类号： G01N33/548 , C08G83/003 , C12Q1/6813 , C12Q2525/313 , G01N33/558 , G01N33/76
摘要： The present invention relates to lateral flow devices and kits using DNA dendrimers, and to methods for detecting an analyte using the lateral flow devices and kits. More specifically, the DNA dendrimers may be dried on a location on the test device upstream from said test zone, before said test device is used.
摘要翻译： 本发明涉及使用DNA树枝状大分子的侧流装置和试剂盒，以及使用侧流装置和试剂盒检测分析物的方法。 更具体地说，在使用所述测试装置之前，DNA树枝状聚合物可以在所述测试区域上游的测试装置的位置上被干燥。
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公开(公告)号：US20170312299A1
公开(公告)日：2017-11-02
申请号：US15631226
申请日：2017-06-23
发明人： Robert C. Getts , James Kadushin , Mindy George-Weinstein , Jacquelyn Gerhart , Emanuela Dylgjeri , Kelly Rhodes
IPC分类号： A61K31/704
CPC分类号： C07K16/28 , A61K31/704 , A61K47/549 , A61K47/62 , A61K47/6849 , A61K47/6859 , Y02A50/411
摘要： Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.
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公开(公告)号：US20150359907A1
公开(公告)日：2015-12-17
申请号：US14764388
申请日：2014-01-31
发明人： Robert C. Getts , Janet Sawicki
CPC分类号： A61K48/0058 , A61K9/0014 , A61K38/45 , A61K47/10 , A61K47/36 , A61K47/64 , A61K47/6829 , A61K47/6849 , A61K48/0041 , A61K48/0075 , C07K14/43595 , C12N9/1077 , C12N15/87 , C12Q1/6897 , C12Q1/708 , C12Y204/02036 , G01N33/5091 , G01N2333/025 , C12Q2525/313
摘要： Compositions are disclosed which comprise a DNA dendrimer having one or more DNA sequences linked thereto, the DNA sequences comprising DNA sequences encoding a polypeptide or regulatory RNA linked to DNA sequences that regulate expression of the DNA sequences encoding a polypeptide or regulatory RNA to produce an RNA coding for the polypeptide or to produce the regulatory RNA. Also disclosed are methods for treating diseases and conditions of cells by delivering the dendrimers to the cells, with subsequent expression of the encoded polypeptide or regulatory RNA.
摘要翻译： 公开了包含具有连接到其上的一个或多个DNA序列的DNA树枝状聚合物的组合物，所述DNA序列包含编码多肽的DNA序列或与调节表达编码多肽或调节RNA的DNA序列的DNA序列相关的调节RNA以产生RNA 编码多肽或产生调节性RNA。 还公开了通过将树枝状大分子递送至细胞来治疗疾病和病症的方法，随后编码的多肽或调节性RNA的表达。
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公开(公告)号：US20140296092A1
公开(公告)日：2014-10-02
申请号：US14187806
申请日：2014-02-24
申请人： Genisphere, LLC
发明人： Robert C. Getts , James Kadushin , Jessica Bowers
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/682 , C40B30/04 , C12Q2525/313 , C12Q2525/173 , C12Q2521/501 , C12Q2565/102 , C12Q2525/207 , C12Q2525/119 , C12Q2537/162 , C12Q2565/501
摘要： Methods, reagents and kits are provided for the production and use in detection assays of labeled nucleic acid molecules wherein a labeling molecule is attached directly to the 3′ end of the nucleic acid molecules.
摘要翻译： 提供了方法，试剂和试剂盒用于生产和用于标记核酸分子的检测测定，其中标记分子直接连接到核酸分子的3'末端。
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公开(公告)号：US20210213138A1
公开(公告)日：2021-07-15
申请号：US15999774
申请日：2017-02-17
申请人： Genisphere LLC
发明人： Robert C. Getts , James M. Kadushin , Lori Getts
摘要： The present disclosure provides nucleic acid carriers comprising targeting agents, pharmaceutical compositions comprising the same, and methods of making and using the same.
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公开(公告)号：US20210162064A1
公开(公告)日：2021-06-03
申请号：US15999781
申请日：2017-02-17
申请人： Genisphere LLC
发明人： Robert C. Getts , James M. Kadushin , Lori Getts
摘要： The present disclosure provides nucleic acid carriers comprising one or more layers comprising multiple monomers, wherein each monomer comprises: a first and a second oligonucleotide; wherein a central portion of each of the first and second oligonucleotides is complementary to each other, forming a double-stranded region, wherein the two terminal portions of the first oligonucleotide are not complementary to the two terminal portions of the second oligonucleotide, forming four terminal arms; and at least one targeting agent conjugated to at least one peripheral terminal arm, wherein when the at least one targeting agent is an miRNA. The present disclosure also provides pharmaceutical composition comprising any of the nucleic acid carriers described herein, and a pharmaceutically acceptable vehicle. The present disclosure also provides methods of inducing an immune response in an animal comprising administering to the animal any of the nucleic acid carriers described herein.
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公开(公告)号：US20210121580A1
公开(公告)日：2021-04-29
申请号：US17015925
申请日：2020-09-09
发明人： Robert C. Getts , Janet Sawicki
IPC分类号： A61K48/00 , C12N15/87 , C12Q1/6897 , C12Q1/70 , A61K47/54 , A61K47/56 , A61K9/00 , A61K47/36 , C07K14/435 , C12N9/10 , G01N33/50 , A61K38/45 , A61K47/10
摘要： Compositions are disclosed which comprise a DNA dendrimer having one or more DNA sequences linked thereto, the DNA sequences comprising DNA sequences encoding a polypeptide or regulatory RNA linked to DNA sequences that regulate expression of the DNA sequences encoding a polypeptide or regulatory RNA to produce an RNA coding for the polypeptide or to produce the regulatory RNA. Also disclosed are methods for treating diseases and conditions of cells by delivering the dendrimers to the cells, with subsequent expression of the encoded polypeptide or regulatory RNA.
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