公开(公告)号：US07329501B2

公开(公告)日：2008-02-12

申请号：US11439587

申请日：2006-05-23

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/53

CPC分类号： C07K14/8114 ,  Y10T436/24

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

公开(公告)号：US20070031979A1

公开(公告)日：2007-02-08

申请号：US11580470

申请日：2006-10-12

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/50 ,  G01N33/543

CPC分类号： C07K14/47 ,  Y10T436/24 ,  Y10T436/255

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

公开(公告)号：US20060211146A1

公开(公告)日：2006-09-21

申请号：US11439588

申请日：2006-05-23

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/543

CPC分类号： C07K14/8114 ,  Y10T436/24

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

公开(公告)号：US20060211143A1

公开(公告)日：2006-09-21

申请号：US11439577

申请日：2006-05-23

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/543

CPC分类号： C07K14/78 ,  Y10T436/24 ,  Y10T436/255

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

公开(公告)号：US20060211048A1

公开(公告)日：2006-09-21

申请号：US11437969

申请日：2006-05-19

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： G01N33/53 ,  G01N33/00

CPC分类号： G01N33/6893 ,  Y10T436/24

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

公开(公告)号：US07097989B2

公开(公告)日：2006-08-29

申请号：US09993287

申请日：2001-11-23

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/567 ,  A61K38/00

CPC分类号： G01N33/564 ,  G01N2800/042 ,  Y10T436/24 ,  Y10T436/255

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的至少一种疾病状态的存在或不存在的能力，预测疾病风险评估以及开发针对该疾病的治疗途径。

公开(公告)号：US07074576B2

公开(公告)日：2006-07-11

申请号：US09992672

申请日：2001-11-23

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/567 ,  A61K38/00

CPC分类号： G01N33/6848 ,  C07K7/08 ,  G01N33/6851 ,  Y10S436/811

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的至少一种疾病状态的存在或不存在的能力，预测疾病风险评估以及开发针对该疾病的治疗途径。

公开(公告)号：US20060134699A1

公开(公告)日：2006-06-22

申请号：US11351461

申请日：2006-02-10

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/53 ,  G01N33/00

CPC分类号： G01N33/6848 ,  C07K14/47 ,  Y10T436/24 ,  Y10T436/255

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of at least one disease state relative to recognition of the presence and/or the absence of the biopolymer, predict disease risk assessment, and develop therapeutic avenues against the disease.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征与识别生物聚合物的存在和/或不存在相关的至少一种疾病状态的存在或不存在的能力，预测疾病风险评估以及开发针对该疾病的治疗途径。

公开(公告)号：US20060084112A1

公开(公告)日：2006-04-20

申请号：US09993300

申请日：2001-11-23

申请人： George Jackowski ,  John Marshall

发明人： George Jackowski ,  John Marshall

IPC分类号： G01N33/53

CPC分类号： G01N33/6896 ,  C07K14/4711 ,  G01N33/564 ,  G01N2500/00 ,  Y10T436/24 ,  Y10T436/255

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer, predict disease risk assessment, and develop therapeutic avenues against said disease.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在的能力，以相对于识别所述生物聚合物的存在和/或不存在，预测疾病风险评估以及开发针对所述疾病的治疗途径。

公开(公告)号：US20050287599A1

公开(公告)日：2005-12-29

申请号：US11144402

申请日：2005-06-03

申请人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

发明人： George Jackowski ,  Brad Thatcher ,  John Marshall ,  Jason Yantha ,  Tammy Vrees

IPC分类号： G01N33/68 ,  C12Q1/68 ,  G01N33/00 ,  G01N33/53

CPC分类号： G01N33/6893

摘要： The instant invention involves the use of a combination of preparatory steps in conjunction with mass spectroscopy and time-of-flight detection procedures to maximize the diversity of biopolymers which are verifiable within a particular sample. The cohort of biopolymers verified within such a sample is then viewed with reference to their ability to evidence at least one particular disease state; thereby enabling a diagnostician to gain the ability to characterize either the presence or absence of said at least one disease state relative to recognition of the presence and/or the absence of said biopolymer.

摘要翻译： 本发明涉及使用组合的准备步骤与质谱法和飞行时间检测程序的组合，以使特定样品中可验证的生物聚合物的多样性最大化。 然后，在这样一个样本中验证的生物聚合物队列参照其证明至少一种特定疾病状态的能力; 从而使得诊断者能够获得表征所述至少一种疾病状态的存在或不存在与识别所述生物聚合物的存在和/或不存在的能力。