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公开(公告)号：US20120015899A1
公开(公告)日：2012-01-19
申请号：US13125482
申请日：2009-10-25
IPC分类号： A61K31/7068 , C12N1/19 , C12N1/21 , A61P35/00 , C12N5/07
CPC分类号： C07K14/005 , A61K48/00 , C07K2319/85 , C12N7/00 , C12N2770/14023 , C12N2770/14042 , C12N2770/14045 , C12N2795/18123 , C12N2810/00 , C12N2810/10 , C12N2810/405
摘要： Aspects of the invention provide modified virus-like particles that are designed for therapeutic applications. In particular, aspects of the invention provide CCMV coat proteins that are modified to generate virus-like particles, including mosaic virus-like particles, that can package and/or deliver one or more diagnostic and/or therapeutic agents. The invention also provides methods for treating subjects with one or more modified virus-like particles.
摘要翻译： 本发明的方面提供被设计用于治疗应用的经修饰的病毒样颗粒。 特别地，本发明的方面提供了经修饰以产生病毒样颗粒（包括花叶病毒样颗粒）的CCMV外壳蛋白，其可包装和/或递送一种或多种诊断和/或治疗剂。 本发明还提供了用一种或多种经修饰的病毒样颗粒治疗受试者的方法。
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公开(公告)号：US08674084B2
公开(公告)日：2014-03-18
申请号：US12812165
申请日：2009-01-08
IPC分类号： C12N15/83 , C12N15/33 , C12N15/113 , A01H5/00
CPC分类号： C12N15/8216 , C12N15/8203 , C12N15/8257 , C12N15/8258
摘要： The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.
摘要翻译： 本发明是基于衍生自RNA-2基因组区段中的目标起始位点已经突变的二分RNA病毒的RNA-2基因组区段的表达增强子序列。 在主要RNA2翻译启动上游的适当起始密码子的缺失可以大大增加外来蛋白质积累而不需要病毒复制。 还提供了方法，载体和系统，包括基于“超可翻译”Cow豆花叶病毒（“CPMV-HT”）的蛋白质表达系统。
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公开(公告)号：US20120174263A1
公开(公告)日：2012-07-05
申请号：US13378347
申请日：2010-06-15
CPC分类号： C12N15/8202 , A61K9/5184 , A61K47/6901 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N15/8257 , C12N15/88 , C12N2770/18022 , C12N2770/18023
摘要： The invention provides methods of producing “empty” RNA virus capsids (e.g. from Cowpea mosaic virus) by assembly of viral small (S) and large (L) coat proteins in such a way that encapsidation of native viral RNA is avoided. Aspects of the invention employ in planta expression of capsid components from DNA vectors encoding the S and L proteins or S-L polyproteins including them. Such capsids have utility for the encapsidation or presentation of foreign proteins or desired payloads.
摘要翻译： 本发明提供通过装配病毒小（S）和大（L）外壳蛋白以避免天然病毒RNA的壳化的方式产生“空”RNA病毒衣壳（例如来自Cow豆花叶病毒）的方法。 本发明的方面在来自编码包含它们的S和L蛋白或S-L多蛋白的DNA载体的植物表达的植物中表达。 这种衣壳具有用于外壳蛋白质或所需有效载荷的壳化或呈递的效用。
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公开(公告)号：US20100287670A1
公开(公告)日：2010-11-11
申请号：US12812165
申请日：2009-01-08
CPC分类号： C12N15/8216 , C12N15/8203 , C12N15/8257 , C12N15/8258
摘要： The inventions is based on an expression enhancer sequence derived from the RNA-2 genome segment of a bipartite RNA virus, in which a target initiation site in the RNA-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main RNA2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication. Also provided are methods, vectors and systems, including the ‘hyper-translatable’ Cowpea Mosaic Virus (‘CPMV-HT’) based protein expression system.
摘要翻译： 本发明是基于衍生自RNA-2基因组区段中的目标起始位点已经突变的二分RNA病毒的RNA-2基因组区段的表达增强子序列。 在主要RNA2翻译启动上游的适当起始密码子的缺失可以大大增加外来蛋白质积累而不需要病毒复制。 还提供了方法，载体和系统，包括基于“超可翻译”Cow豆花叶病毒（“CPMV-HT”）的蛋白质表达系统。
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