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公开(公告)号:US20120015899A1
公开(公告)日:2012-01-19
申请号:US13125482
申请日:2009-10-25
IPC分类号: A61K31/7068 , C12N1/19 , C12N1/21 , A61P35/00 , C12N5/07
CPC分类号: C07K14/005 , A61K48/00 , C07K2319/85 , C12N7/00 , C12N2770/14023 , C12N2770/14042 , C12N2770/14045 , C12N2795/18123 , C12N2810/00 , C12N2810/10 , C12N2810/405
摘要: Aspects of the invention provide modified virus-like particles that are designed for therapeutic applications. In particular, aspects of the invention provide CCMV coat proteins that are modified to generate virus-like particles, including mosaic virus-like particles, that can package and/or deliver one or more diagnostic and/or therapeutic agents. The invention also provides methods for treating subjects with one or more modified virus-like particles.
摘要翻译: 本发明的方面提供被设计用于治疗应用的经修饰的病毒样颗粒。 特别地,本发明的方面提供了经修饰以产生病毒样颗粒(包括花叶病毒样颗粒)的CCMV外壳蛋白,其可包装和/或递送一种或多种诊断和/或治疗剂。 本发明还提供了用一种或多种经修饰的病毒样颗粒治疗受试者的方法。
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公开(公告)号:US20210260182A1
公开(公告)日:2021-08-26
申请号:US17187678
申请日:2021-02-26
申请人: Scott J. Goebel , David Evans , Ryan Noyce , Tonix Pharmaceuticals Holding Corp. , The Governors of the University of Alberta
发明人: Seth Lederman , Scott J. Goebel , David Evans , Ryan Noyce
IPC分类号: A61K39/215 , C12N7/00 , C12N15/85
摘要: The invention relates in various aspects to a recombinant poxvirus comprising a nucleic acid encoding a SARS-CoV-2 virus protein, methods for producing such viruses and the use of such viruses. The recombinant poxviruses are well suited, among others, as protective virus vaccines against SARS-CoV-2 virus.
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公开(公告)号:US09718768B2
公开(公告)日:2017-08-01
申请号:US14111305
申请日:2012-04-12
申请人: David Evans
发明人: David Evans
IPC分类号: C07K9/00 , C07C319/28 , A61K47/48 , B01J20/287 , B01J20/32 , C07K1/22 , C07C59/347 , C07C323/58 , C07K17/02
CPC分类号: C07C319/28 , A61K47/6817 , A61K47/6855 , B01J20/287 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/3251 , B01J20/3274 , C07C59/347 , C07C323/58 , C07K1/22 , C07K17/02 , Y10T428/2982
摘要: The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.
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公开(公告)号:US09150574B2
公开(公告)日:2015-10-06
申请号:US14344417
申请日:2011-09-14
申请人: David Evans , Allison Carley , Alison Stewart , Michael Higginbottom , Edward Savory , Iain Simpson , Marianne Nilsson , Martin Haraldsson , Erik Nordling , Tobias Koolmeister
发明人: David Evans , Allison Carley , Alison Stewart , Michael Higginbottom , Edward Savory , Iain Simpson , Marianne Nilsson , Martin Haraldsson , Erik Nordling , Tobias Koolmeister
IPC分类号: C07D471/02 , A61K31/55 , C07D471/04
CPC分类号: C07D471/04
摘要: 2-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}ethan-1-amine; 3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate; 1-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}-4-(dimethylamino)butan-1-one; 5-amino-1-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}pentan-1-one; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; N-(3-aminopropyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-N-[3-(dimethylamino)propyl]piperidine-1-carboxamide; 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)piperazine; 4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine; 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-1,4-diazepane; ethyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; ethyl 1-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylic acid; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxamide; 4-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4yl}carbonyl)morpholine; 1-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4-yl}carbonyl)piperazine; {4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}methanol; {4-[1-(4-methyl-phenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methanol; [(3R)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl]methanol; methyl 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxylate; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxamide; 2-{4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}ethan-1-ol; methyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxylate; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxamide; 1-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-2-yl}carbonyl)piperazine; 4-[1-(4-methylphenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]morpholine; 1-(4-chlorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-c]pyridin-4-ol; N-butyl-1-(4-chlorophenyl)-N-methyl-1H-pyrazolo[3,4-c]pyridin-3-amine; 1-[4-(fluoromethyl)phenyl]-3-(oxan-4-yl)-1H-pyrazolo[3,4-c]pyridine; and 3-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-1-yl}methyl)pyridine are useful for the inhibition of SSAO activity.
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公开(公告)号:US09005926B2
公开(公告)日:2015-04-14
申请号:US13499858
申请日:2010-10-01
IPC分类号: C07K1/04 , C07K1/113 , C07K16/00 , C07K1/26 , G01N30/02 , G01N33/534 , G01N33/563
CPC分类号: C07K16/00 , C07K1/1133
摘要: The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.
摘要翻译: 本发明涉及在蛋白质如抗体中预防和消除三硫键的方法。 在一个实施方案中,作为色谱纯化方法的一部分,将蛋白质中的三硫键转化为二硫键。 在另一个实施方案中,通过在这些蛋白质的细胞培养生产期间实施本文所述的方法来抑制蛋白质中三硫键的形成。 在另一个实施方案中,通过本文所述的方法产生单克隆抗体。
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公开(公告)号:US20140304906A1
公开(公告)日:2014-10-16
申请号:US13859818
申请日:2013-04-10
申请人: Walter Judson Bennett , David Evans
发明人: Walter Judson Bennett , David Evans
CPC分类号: E02D3/00 , E04H4/0037 , E04H4/0056 , E04H2004/146 , Y10T29/49801
摘要: The present invention relates to a new construction method for swimming pools, surfing pools, body boarding pools, wave pools, water park pools, kayaking and white water rafting courses and pools, wake boarding pools, water skiing pools and jet skiing pools, static surfing simulators, deep water river standing wave attractions. The present invention construction method can also be used in lagoons, ponds, lakes, and rivers. The invention will save construction costs, and save pool construction time.
摘要翻译: 本发明涉及游泳池,冲浪池,身体游泳池,波浪池,水上公园游泳池,皮划艇和白水漂流课程和游泳池,唤醒游泳池,滑水游泳池和喷气式滑雪游泳池的新的施工方法,静态冲浪 模拟器,深水河站立波浪景点。 本发明的施工方法也可用于泻湖,池塘,湖泊和河流。 本发明可节省施工成本,节约施工时间。
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公开(公告)号:USD711059S1
公开(公告)日:2014-08-12
申请号:US29405714
申请日:2011-11-04
申请人: David Evans , Ashley May
设计人: David Evans , Ashley May
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公开(公告)号:US08367921B2
公开(公告)日:2013-02-05
申请号:US11568265
申请日:2005-01-31
申请人: David Evans , Benjamin Ruciak , William Thorpe
发明人: David Evans , Benjamin Ruciak , William Thorpe
IPC分类号: G04B13/00
摘要: The invention relates to a method and system for assessing a performance of a musical composition in relation to a model performance of the same composition. In particular, as even a model performance does not follow a score of a composition precisely, the present invention initially correlates the model performance to a score of the performed composition. This allows for an accurate assessment of the timing of the assessable performance, relative to the timing of the model performance. The invention is of particular use where the assessable performance is performed along with the model performance, but the two performances are remote from each other.
摘要翻译: 本发明涉及一种用于评估与相同构图的模型演奏相关的乐曲的演奏的方法和系统。 特别地,即使模型性能也不能精确地跟随组合得分,本发明最初将模型性能与所执行的组合的得分相关联。 这样可以准确地评估可评估绩效的时间,相对于模型绩效的时间。 本发明在评估性能与模型性能一起执行时具有特别的用途,但两种性能彼此远离。
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公开(公告)号:US08358268B2
公开(公告)日:2013-01-22
申请号:US12178415
申请日:2008-07-23
申请人: David Evans
发明人: David Evans
IPC分类号: G09G5/00
CPC分类号: G06F3/041 , G01S7/003 , G01S7/497 , G01S15/876 , G01S17/87
摘要: A multi-touch system is provided. The multi-touch system includes a multi-touch detection area generated by a mobile device and a first communication device, the mobile device and first or second communication device being movable relative to each other. The mobile device is operable to determine a first set of coordinates for a first detectable object within the multi-touch detection area as a function of: a distance between the mobile device and the first communication device, a distance between the mobile device and first detectable object, and a distance between the first communication device and first detectable object.
摘要翻译: 提供多点触控系统。 多点触摸系统包括由移动设备和第一通信设备生成的多点触摸检测区域,移动设备和第一或第二通信设备可相对于彼此移动。 移动设备可操作以根据以下功能确定多点触摸检测区域内的第一可检测对象的第一组坐标:移动设备与第一通信设备之间的距离,移动设备与第一可检测对象之间的距离 物体和第一通信设备与第一可检测对象之间的距离。
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公开(公告)号:US20120232599A1
公开(公告)日:2012-09-13
申请号:US13044775
申请日:2011-03-10
申请人: Jared Schoenly , David Evans , Matthew Fenn
发明人: Jared Schoenly , David Evans , Matthew Fenn
CPC分类号: A61B17/863 , A61B17/8057 , A61B17/8635 , A61F2/28 , A61F2/30744 , A61F2/30749 , A61F2/30771 , A61F2/30965 , A61F2/442 , A61F2/4455 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30306 , A61F2002/30387 , A61F2002/30509 , A61F2002/30514 , A61F2002/30517 , A61F2002/30578 , A61F2002/30604 , A61F2002/30616 , A61F2002/30777 , A61F2002/30784 , A61F2002/30787 , A61F2002/30841 , A61F2002/30843 , A61F2002/30845 , A61F2002/30879 , A61F2002/30904 , A61F2002/4475 , A61F2310/00017 , A61F2310/00023 , A61F2310/00359
摘要: Provided are fixation members useful in fixing an implant to a bone. The fixation members include an awl tip so as to enable their secure installation by use of an awling motion, which in turn speeds the installation of the fixation members.
摘要翻译: 提供了用于将植入物固定到骨上的固定构件。 固定构件包括锥尖,以便能够通过使用突然的动作使其安全地安装,这进而加速了固定构件的安装。
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