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公开(公告)号：US20120015899A1
公开(公告)日：2012-01-19
申请号：US13125482
申请日：2009-10-25
IPC分类号： A61K31/7068 , C12N1/19 , C12N1/21 , A61P35/00 , C12N5/07
CPC分类号： C07K14/005 , A61K48/00 , C07K2319/85 , C12N7/00 , C12N2770/14023 , C12N2770/14042 , C12N2770/14045 , C12N2795/18123 , C12N2810/00 , C12N2810/10 , C12N2810/405
摘要： Aspects of the invention provide modified virus-like particles that are designed for therapeutic applications. In particular, aspects of the invention provide CCMV coat proteins that are modified to generate virus-like particles, including mosaic virus-like particles, that can package and/or deliver one or more diagnostic and/or therapeutic agents. The invention also provides methods for treating subjects with one or more modified virus-like particles.
摘要翻译： 本发明的方面提供被设计用于治疗应用的经修饰的病毒样颗粒。 特别地，本发明的方面提供了经修饰以产生病毒样颗粒（包括花叶病毒样颗粒）的CCMV外壳蛋白，其可包装和/或递送一种或多种诊断和/或治疗剂。 本发明还提供了用一种或多种经修饰的病毒样颗粒治疗受试者的方法。
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2.发明申请Virion Derived Protein Nanoparticles For Delivering Radioisotopes For The Diagnosis And Treatment Of Malignant And Systemic Disease And The Monitoring Of Therapy 审中-公开用于提供放射性同位素的病毒衍生蛋白质纳米颗粒用于恶性和系统性疾病的诊断和治疗以及治疗监测公开(公告)号：US20130116408A1
公开(公告)日：2013-05-09
申请号：US13469934
申请日：2012-05-11
CPC分类号： C07K14/005 , C12N7/00 , C12N2710/20023 , C12N2710/20042 , C12N2800/22
摘要： The invention is directed to novel compositions and methods utilizing virion derived protein nanoparticles for delivery of medical imaging agents and therapeutic agents for the diagnosis and treatment of malignant and systemic diseases. The nanoparticles of the present invention are designed to deliver radioactive isotopes suitable for imaging a tumor and its metastases. Additionally, the nanoparticles may deliver a radioisotope that is suitable for treating a tumor and its metastases by alpha, beta or gamma radiation. Alternatively, the virion derived nanoparticles may deliver a treatment agent for cancer or a combination of a radioisotope and a cancer treatment agent. Additionally the virion derived nanoparticle may include delivery of a drug that enhances the immune system's recognition of the tumor.
摘要翻译： 本发明涉及利用病毒衍生的蛋白质纳米颗粒递送用于诊断和治疗恶性和全身性疾病的医学成像剂和治疗剂的新型组合物和方法。 本发明的纳米颗粒被设计用于递送适于成像肿瘤及其转移的放射性同位素。 此外，纳米颗粒可以递送适于通过α，β或γ辐射治疗肿瘤及其转移的放射性同位素。 或者，衍生的病毒颗粒可递送癌症治疗剂或放射性同位素和癌症治疗剂的组合。 另外，病毒颗粒衍生的纳米颗粒可以包括递送增强免疫系统对肿瘤的识别的药物。
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3.发明申请Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For The Treatment Of Dermatology Related Genetic Diseases 审中-公开用于提供诊断或治疗药物的病毒衍生蛋白质纳米颗粒用于皮肤病学相关遗传疾病公开(公告)号：US20130012450A1
公开(公告)日：2013-01-10
申请号：US13356363
申请日：2012-01-23
CPC分类号： A61K35/76 , A61K38/162 , A61K2300/00
摘要： This invention relates to a transdermal delivery system for treating skin related genetic diseases. More specifically, the present invention provides particles and methods for using pseudo-viruses, including those derived from the herpes and papillomaviruses, to deliver drugs to keratinocytes and basal membrane cells for the treatment of skin genetic disorders including Pachyonychia Congenita and Xeroderma Pigmentosum.
摘要翻译： 本发明涉及一种用于治疗皮肤相关遗传疾病的透皮递送系统。 更具体地，本发明提供了使用假病毒（包括衍生自疱疹和乳头瘤病毒的假病毒）的颗粒和方法，将药物递送到角质形成细胞和基底膜细胞，用于治疗皮肤遗传疾病，包括先天性心ita和皮肤色素沉着。
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4.发明申请Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For the Treatment of Psoriasis 审中-公开用于提供用于治疗牛皮癣的诊断或治疗剂的病毒衍生蛋白质纳米颗粒公开(公告)号：US20130012426A1
公开(公告)日：2013-01-10
申请号：US13273206
申请日：2011-10-13
CPC分类号： A61K35/76 , A61K38/162 , A61K2300/00
摘要： This invention relates to a transdermal delivery system for treating skin related diseases employing protein nanoparticles to deliver drugs to the keratinocytes and basal membrane cells for the treatment of Psoriasis. The current invention presents an effective method for delivering small molecule nucleic acids to the epidermal cells.
摘要翻译： 本发明涉及一种用于治疗皮肤相关疾病的透皮递送系统，其使用蛋白质纳米颗粒将药物递送至角质形成细胞和基底膜细胞用于治疗牛皮癣。 本发明提供了将小分子核酸递送到表皮细胞的有效方法。
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公开(公告)号：US09724404B2
公开(公告)日：2017-08-08
申请号：US13264213
申请日：2009-07-24
申请人： Pierre L. Coursaget , Antoine A. Touzé , Maxime J. J. Fleury , Nicolas Combelas , Elisabet de los Pinos
发明人： Pierre L. Coursaget , Antoine A. Touzé , Maxime J. J. Fleury , Nicolas Combelas , Elisabet de los Pinos
IPC分类号： A01N63/00 , A61K39/00 , A61K39/12 , C07K14/005 , C07K16/08 , C12N7/00 , C12N15/11 , C12N15/88
CPC分类号： A61K39/12 , A61K39/0011 , A61K2039/5258 , C07K14/005 , C07K16/084 , C07K2317/34 , C12N7/00 , C12N15/111 , C12N15/88 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2710/14143 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2800/22
摘要： The invention relates to modified HPV particles that can be used therapeutically. Modified HPV particles may be used to deliver therapeutic agents, including siRNA molecules. Modified HPV particles may be used for the treatment of diseases or conditions of mucosal tissue, including HPV (human papilloma virus) infection and HPV-related tumors.
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6.发明申请Virion Derived Protein Nanoparticles For Delivering Radioisotopes For The Diagnosis And Treatment Of Malignant And Systemic Disease And The Monitoring Of Therapy 审中-公开用于提供放射性同位素的病毒衍生蛋白质纳米颗粒用于恶性和系统性疾病的诊断和治疗以及治疗监测公开(公告)号：US20130115247A1
公开(公告)日：2013-05-09
申请号：US13367296
申请日：2012-02-06
IPC分类号： A61K9/00 , A61K31/7088 , A61K38/16
CPC分类号： A61K51/1203 , A61K9/5184
摘要： The invention is directed to novel compositions and methods utilizing virion derived protein nanoparticles for delivery of medical imaging agents and therapeutic agents for the diagnosis and treatment of malignant and systemic diseases.
摘要翻译： 本发明涉及利用病毒衍生的蛋白质纳米颗粒递送用于诊断和治疗恶性和全身性疾病的医学成像剂和治疗剂的新型组合物和方法。
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公开(公告)号：US20220387619A2
公开(公告)日：2022-12-08
申请号：US17395369
申请日：2021-08-05
IPC分类号： A61K47/69 , A61K41/00 , A61K39/12 , A61K47/64 , C07K1/13 , C07K14/025 , C07K16/08 , C07K16/32 , A61N5/06 , C12N7/00
摘要： The present disclosure is directed to methods and compositions for the diagnosis and/or treatment of tumors, such as ocular tumors, using virus-like particles conjugated to photosensitive molecules.
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8.发明申请Virion Derived Protein Nanoparticles For Delivering Diagnostic Or Therapeutic Agents For The Treatment Of Non-Melanoma Skin Cancer 审中-公开用于提供用于治疗非黑色素瘤皮肤癌的诊断或治疗剂的病毒衍生蛋白质纳米颗粒公开(公告)号：US20120207840A1
公开(公告)日：2012-08-16
申请号：US13351930
申请日：2012-01-17
CPC分类号： C12N7/00 , A61K9/0014 , A61K9/5176 , A61K35/763 , A61K38/162 , C12N15/113 , C12N2310/14 , C12N2320/32 , C12N2710/20023 , C12N2710/20042
摘要： This invention relates to a transdermal delivery system for treating skin related diseases employing protein nanoparticles to deliver drugs to the keratinocytes and basal membrane cells for the treatment of non-melanoma skin cancer. The current invention presents an effective method for delivering small molecule nucleic acids to the epidermal cells.
摘要翻译： 本发明涉及一种用于治疗皮肤相关疾病的透皮递送系统，其使用蛋白质纳米颗粒将药物递送至角质形成细胞和基底膜细胞用于治疗非黑素瘤皮肤癌。 本发明提供了将小分子核酸递送到表皮细胞的有效方法。
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公开(公告)号：US20120171290A1
公开(公告)日：2012-07-05
申请号：US13264213
申请日：2009-07-24
申请人： Pierre L. Coursaget , Antoine A. Touzé , Maxime J.J. Fleury , Nicolas Combelas , Elisabet de los Pinos
发明人： Pierre L. Coursaget , Antoine A. Touzé , Maxime J.J. Fleury , Nicolas Combelas , Elisabet de los Pinos
CPC分类号： A61K39/12 , A61K39/0011 , A61K2039/5258 , C07K14/005 , C07K16/084 , C07K2317/34 , C12N7/00 , C12N15/111 , C12N15/88 , C12N2310/11 , C12N2310/14 , C12N2320/32 , C12N2710/14143 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , C12N2800/22
摘要： The invention relates to modified HPV particles that can be used therapeutically. Modified HPV particles may be used to deliver therapeutic agents, including siRNA molecules. Modified HPV particles may be used for the treatment of diseases or conditions of mucosal tissue, including HPV (human papilloma virus) infection and HPV-related tumors.
摘要翻译： 本发明涉及可用于治疗的改良的HPV颗粒。 修饰的HPV颗粒可用于递送治疗剂，包括siRNA分子。 修饰的HPV颗粒可用于治疗粘膜组织的疾病或病症，包括HPV（人乳头瘤病毒）感染和HPV相关肿瘤。
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