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    ENCAPSULATED AGENT GUIDED IMAGING AND THERAPIES
    1.
    发明申请
    ENCAPSULATED AGENT GUIDED IMAGING AND THERAPIES 审中-公开
    包埋剂引导成像和治疗

    公开(公告)号：US20110311455A1

    公开(公告)日：2011-12-22

    申请号：US13156218

    申请日：2011-06-08

    申请人： Bahman Anvari

    发明人： Bahman Anvari

    IPC分类号： A61K49/00 ,  A61K31/403 ,  A61K31/409 ,  A61K31/197 ,  B01J19/12 ,  A61K49/22 ,  A61K49/04 ,  A61K49/18 ,  A61K9/14 ,  A61K9/00 ,  A61K31/221

    CPC分类号： C12N7/00 ,  A61K47/6901 ,  C12N2770/14023 ,  C12N2770/14042

    摘要： A nano-capsule construct for imaging and therapeutic uses and method for production are provided. One nano-probe embodiment based on genome-depleted plant brome mosaic virus (BMV) whose interior is doped with indocyanine green (ICG), an FDA-approved near infrared fluorescent dye, is used to illustrate the invention. The material encapsulated in viral shell components may be coated with functionalized coatings such as branched, dendritic polymer coatings to improve longevity and distribution in the body as well as antibody conjugation for increased target specificity. The constructs can also be coated with ferromagnetic iron oxide nanoparticles, enabling the ICG-containing capsules to be used as nano-probes with the capability of being detected in both optical and magnetic resonance imaging. The capsules may be produced by purifying a plant or animal viruses and disassembling the viruses to provide virus shell components. The virus shell components are reassembled in the presence of a material for encapsulation thereby encapsulating said material within the core of the construct in one embodiment.

    摘要翻译： 提供了用于成像和治疗用途的纳米胶囊构造物和生产方法。 基于枯草芽孢杆菌病毒（BMV）的一个纳米探针实施方案，其内部掺杂有吲哚菁绿（ICG），FDA批准的近红外荧光染料，用于说明本发明。 封装在病毒壳组分中的材料可以用官能化涂层（例如支化树枝状聚合物涂层）涂覆以改善身体的寿命和分布以及增加靶特异性的抗体缀合。 构建体还可以用铁磁性氧化铁纳米颗粒涂覆，使含ICG的胶囊能够用作具有在光学和磁共振成像中被检测的能力的纳米探针。 胶囊可以通过纯化植物或动物病毒并分解病毒以提供病毒壳组分来产生。 病毒壳组分在用于封装的材料的存在下被重新组装，从而在一个实施方案中将所述材料封装在构建体的芯内。

    IN VITRO RECONSTITUTED PLANT VIRUS CAPSIDS FOR DELIVERING RNA GENES TO MAMMALIAN CELLS
    2.
    发明申请
    IN VITRO RECONSTITUTED PLANT VIRUS CAPSIDS FOR DELIVERING RNA GENES TO MAMMALIAN CELLS 有权
    在体外重建植物病毒CAPSIDS中将RNA基因递送给妈妈细胞

    公开(公告)号：US20150140663A1

    公开(公告)日：2015-05-21

    申请号：US14540816

    申请日：2014-11-13

    申请人： The Regents of the University of California

    发明人： William M. Gelbart ,  Charles M. Knobler ,  Rees F. Garmann ,  Odisse Azizgolshani ,  Ruben D. Cadena-Nava

    IPC分类号： C12N15/86

    CPC分类号： C12N7/00 ,  C07K14/005 ,  C12N7/045 ,  C12N9/1247 ,  C12N2770/14022 ,  C12N2770/14023 ,  C12N2770/14033 ,  C12N2770/14042 ,  C12Y207/07006

    摘要： The invention provides compositions of matter comprising a cowpea chlorotic mottle virus capsid protein (CCMV CP) and a ribonucleic acid, as well as methods for using such compositions. In such compositions, the cowpea chlorotic mottle virus capsid protein envelops the ribonucleic acid so as to for a capsid that can inhibit the degradation of the ribonucleic acid (e.g. by RNAses). A method of delivering a ribonucleic acid into the cytoplasm of a mammalian cell is also provided. Typically, the method comprises the steps of combining the mammalian cell with a composition of matter described herein under conditions selected to allow the cowpea chlorotic mottle virus capsid to contact the mammalian cell and deliver the ribonucleic acid into the cytoplasm of a mammalian cell.

    摘要翻译： 本发明提供了包含cow豆褪绿斑驳病毒衣壳蛋白（CCMV CP）和核糖核酸的物质组合物，以及使用这些组合物的方法。 在这种组合物中，cow豆褪绿斑驳病毒衣壳蛋白包裹核糖核酸，以便可以抑制核糖核酸降解的衣壳（例如通过RNA酶）。 还提供了将核糖核酸递送到哺乳动物细胞的细胞质中的方法。 通常，该方法包括以下步骤：将哺乳动物细胞与本文所述物质的组合物在选择为允许cow豆褪绿斑驳病毒衣壳接触哺乳动物细胞并将核糖核酸递送至哺乳动物细胞的细胞质的条件下组合。