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    DETECTING NITRIC OXIDE
    3.
    发明申请
    DETECTING NITRIC OXIDE 审中-公开
    检测氮氧化物

    公开(公告)号：US20080107569A1

    公开(公告)日：2008-05-08

    申请号：US11855817

    申请日：2007-09-14

    申请人： George Stefano ,  Kirk Mantione

    发明人： George Stefano ,  Kirk Mantione

    IPC分类号： G01N33/497

    CPC分类号： G01N33/0037 ,  A61B5/097 ,  G01N33/497 ,  Y02A50/245

    摘要： This document provides methods and materials that can be used to measure NO. For example, NO sensing devices, methods for making NO sensing devices, and methods for using NO sensing devices to measure NO in, for example, exhaled human breath are provided.

    摘要翻译： 本文档提供了可用于测量NO的方法和材料。 例如，提供了NO感测装置，用于制造NO感测装置的方法，以及用于使用NO感测装置来测量例如呼出的人呼吸中的NO的方法。

    OPIATE, CANNABINOID, AND ESTROGEN RECEPTORS
    4.
    发明申请
    OPIATE, CANNABINOID, AND ESTROGEN RECEPTORS 审中-公开
    OPIATE，CANNABINOID和雌激素受体

    公开(公告)号：US20070087390A1

    公开(公告)日：2007-04-19

    申请号：US11465790

    申请日：2006-08-18

    申请人： George Stefano ,  Caterina Fimiani

    发明人： George Stefano ,  Caterina Fimiani

    IPC分类号： G01N33/574 ,  G01N33/567

    CPC分类号： G01N33/5011 ,  A61K31/00 ,  A61K31/138 ,  A61K45/06 ,  A61K47/6425 ,  C07K14/705 ,  C07K14/721 ,  G01N33/5008 ,  G01N33/502 ,  G01N33/5064 ,  G01N33/6872 ,  G01N33/948 ,  G01N33/9486 ,  G01N2333/723 ,  G01N2800/102 ,  G01N2800/104 ,  G01N2800/328

    摘要： The present invention relates generally to mu3 opiate receptors, cannabinoid receptors, and estrogen surface receptors (ESRs). Specifically, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists, cannabinoid receptor agonists and antagonists, and ESR agonists and antagonists. In addition, the invention provides an isolated nucleic acid molecule that encodes a mu3 opioid receptor, a host cell containing an isolated nucleic acid molecule that encodes a mu3 opioid receptor, and an isolated mu3 opioid receptor polypeptide. Further, the invention provides methods and materials for treating cancers, inflammatory conditions, sepsis conditions, viral infections, and cardiovascular diseases.

    摘要翻译： 本发明一般涉及mu3鸦片类受体，大麻素受体和雌激素表面受体（ESR）。 具体地，本发明提供了用于鉴定mu3鸦片剂受体激动剂和拮抗剂，大麻素受体激动剂和拮抗剂以及ESR激动剂和拮抗剂的方法和材料。 此外，本发明提供编码mu3阿片受体的分离的核酸分子，含有编码mu3阿片受体的分离的核酸分子的宿主细胞和分离的mu3阿片受体多肽。 此外，本发明提供了治疗癌症，炎性病症，败血病病症，病毒感染和心血管疾病的方法和材料。

    Nucleic acids encoding opiate receptors
    5.
    发明申请
    Nucleic acids encoding opiate receptors 有权

    公开(公告)号：US20060229444A1

    公开(公告)日：2006-10-12

    申请号：US11454213

    申请日：2006-06-15

    申请人： Patrick Cadet ,  George Stefano

    发明人： Patrick Cadet ,  George Stefano

    IPC分类号： C07H21/04

    CPC分类号： G01N33/9486 ,  C07K14/705 ,  G01N2333/90245 ,  G01N2500/10

    摘要： The invention provides isolated nucleic acid molecules, host cells that contain an isolated nucleic acid molecule, and substantially pure polypeptides. For example, the invention provides isolated nucleic acid molecules that encode polypeptides having mu3 opiate receptor activity, host cells that contain an isolated nucleic acid molecule that encodes a polypeptide having mu3 opiate receptor activity, and substantially pure polypeptides that have mu3 opiate receptor activity. In addition, the invention provides methods and materials for identifying mu3 opiate receptor agonists and antagonists.

    Anti-inflammatory signal molecules and exercise
    6.
    发明申请
    Anti-inflammatory signal molecules and exercise 审中-公开
    抗炎信号分子和运动

    公开(公告)号：US20050037518A1

    公开(公告)日：2005-02-17

    申请号：US10916655

    申请日：2004-08-12

    申请人： George Stefano

    发明人： George Stefano

    IPC分类号： G01N33/543 ,  G01N33/68 ,  G01N33/74 ,  G01N33/94

    CPC分类号： G01N33/6869 ,  G01N33/74 ,  G01N33/743 ,  G01N33/9486

    摘要： The present invention provides methods for assessing the effect of exercise on an individual by measuring changes in the concentration of a compound in the individual's blood. Specifically, the invention measures changes in the concentration of an anti-inflammatory signal molecule or endogenous morphine. Anti-inflammatory signal molecules include, for example, adrenocorticotropin (ACTH), cortisol, and interleukin-10 (IL-10). A first embodiment of the invention provides a method for assessing the effect of exercise on an individual comprising the steps of measuring a concentration of at least one compound in the individual's blood before exercise, measuring a concentration of the at least one compound in the individual's blood after exercise, and comparing the concentrations of the at least one compound.

    摘要翻译： 本发明提供了通过测量个体血液中化合物浓度的变化来评估运动对个体的影响的方法。 具体地，本发明测量抗炎信号分子或内源吗啡浓度的变化。 抗炎信号分子包括例如促肾上腺皮质激素（ACTH），皮质醇和白细胞介素-10（IL-10）。 本发明的第一实施例提供了一种用于评估运动对个体的影响的方法，包括以下步骤：测量运动前个体血液中至少一种化合物的浓度，测量个体血液中至少一种化合物的浓度 并且比较所述至少一种化合物的浓度。