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公开(公告)号：US20130123816A1
公开(公告)日：2013-05-16
申请号：US13293215
申请日：2011-11-10
申请人： Gerald Hodgkinson , Ahmad Robert Hadba , Michael Prescott , Richard P. Stevenson , Arthur Hislop
发明人： Gerald Hodgkinson , Ahmad Robert Hadba , Michael Prescott , Richard P. Stevenson , Arthur Hislop
CPC分类号： A61L31/14 , A61B17/07292 , A61L31/06 , D06M10/025 , Y10T156/1052 , C08L67/04
摘要： A medical device including a plasma-treated porous substrate that is functionalized to provide a hydrophilic surface, and a process for preparing such a medical device, are disclosed. The method includes plasma treating at least a portion of a surface of a porous substrate with a gas species selected from oxygen, nitrogen, argon, and combination thereof. The gas species is configured to functionalize the surface of the medical device and form a hydrophilic surface.
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公开(公告)号：US20100268272A1
公开(公告)日：2010-10-21
申请号：US12783977
申请日：2010-05-20
申请人： David Kirsch , Michael Primavera , Ahmad Robert Hadba , Gerald Hodgkinson , Timothy D. Kosa , Nicholas Maiorino
发明人： David Kirsch , Michael Primavera , Ahmad Robert Hadba , Gerald Hodgkinson , Timothy D. Kosa , Nicholas Maiorino
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/06166 , A61B2017/00867 , A61B2017/00871 , A61B2017/0404 , A61B2017/0406 , A61B2017/0412 , A61B2017/06176
摘要： A medical device having an elongate body at a proximal portion, a distal portion of the elongate body forming a loop at a distal portion of the anchoring device. The loop may further include a plurality of barbs disposed along a surface thereof and the loop also including an end effector. The elongate body, loop, and/or medical device may be formed from shape memory polymers. Methods for securing medical devices of the present disclosure are also disclosed.
摘要翻译： 一种在近端部分具有细长主体的医疗装置，细长体的远端部分在锚定装置的远端部分处形成环。 环可以进一步包括沿其表面设置的多个倒钩，并且该环还包括端部执行器。 细长体，环和/或医疗装置可以由形状记忆聚合物形成。 还公开了用于确保本公开的医疗装置的方法。
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公开(公告)号：US20100204730A1
公开(公告)日：2010-08-12
申请号：US12729846
申请日：2010-03-23
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B17/0401 , A61B2017/00526 , A61B2017/00867 , A61B2017/00871 , A61B2017/00893 , A61B2017/0403 , A61B2017/0417 , A61B2017/0427 , A61B2017/0464 , A61B2017/0477 , A61B2017/06176 , A61B2017/0647
摘要： A suture including a knotted end effector is provided. The suture includes a body portion defining a longitudinal axis and an end effector formed from the body portion. The end effector includes first and second extensions which extend outwardly from the longitudinal axis in opposite directions when the end effector is in a permanent configuration. The extensions of the end effector extend substantially along the longitudinal axis when the end effector is in a temporary position. In embodiments, at least a portion of the end effector includes a shape memory material.
摘要翻译： 提供包括打结末端执行器的缝合线。 缝合线包括限定纵向轴线的主体部分和由主体部分形成的端部执行器。 末端执行器包括第一和第二延伸部，当末端执行器处于永久构型时，第一和第二延伸部在相反方向上从纵向轴线向外延伸。 当末端执行器处于临时位置时，末端执行器的延伸部基本上沿着纵向轴线延伸。 在实施例中，端部执行器的至少一部分包括形状记忆材料。
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公开(公告)号：US09034011B2
公开(公告)日：2015-05-19
申请号：US12783977
申请日：2010-05-20
申请人： David Kirsch , Michael Primavera , Ahmad Robert Hadba , Gerald Hodgkinson , Timothy D. Kosa , Nicholas Maiorino
发明人： David Kirsch , Michael Primavera , Ahmad Robert Hadba , Gerald Hodgkinson , Timothy D. Kosa , Nicholas Maiorino
CPC分类号： A61B17/0401 , A61B17/06166 , A61B2017/00867 , A61B2017/00871 , A61B2017/0404 , A61B2017/0406 , A61B2017/0412 , A61B2017/06176
摘要： A medical device includes an elongate body having a proximal portion and a distal portion. The proximal portion of the elongate body terminates in a free end and the distal portion forms a loop. The loop includes a proximal portion and a distal portion, and a plurality of barbs disposed along a surface thereof. A pledget is disposed adjacent the proximal portion of the loop. The elongate body, loop, and/or barbs may be formed from shape memory polymers that are configured to change shape in vivo upon application of energy. Methods for securing medical devices of the present disclosure are also disclosed.
摘要翻译： 医疗装置包括具有近端部分和远端部分的细长主体。 细长体的近端部分终止于自由端，并且远侧部分形成环。 该环包括近端部分和远端部分，以及沿其表面设置的多个倒钩。 邻近邻近环路的近端部分设置一个绒毛。 长形体，环和/或倒刺可以由形状记忆聚合物形成，其被配置成在施加能量时在体内改变形状。 还公开了用于确保本公开的医疗装置的方法。
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公开(公告)号：US08888810B2
公开(公告)日：2014-11-18
申请号：US12726815
申请日：2010-03-18
申请人： Ahmad Robert Hadba , Gerald Hodgkinson , Seth Gleiman , Matthew D. Cohen , Nicholas Maiorino , Timothy D. Kosa , Mark S. Buchter , Michael Primavera
发明人： Ahmad Robert Hadba , Gerald Hodgkinson , Seth Gleiman , Matthew D. Cohen , Nicholas Maiorino , Timothy D. Kosa , Mark S. Buchter , Michael Primavera
IPC分类号： A61B17/08 , A61B17/064 , A61B17/00 , A61B17/06
CPC分类号： A61B17/064 , A61B17/06166 , A61B2017/00004 , A61B2017/00526 , A61B2017/00867 , A61B2017/00893 , A61B2017/06176 , B21G7/02
摘要： Barbed medical devices include a crown interconnecting a pair of legs and at least one barb extending from each of the legs. The at least one barb may define an inner surface with a first portion disposed at a first orientation relative to a longitudinal axis of the leg, a second portion disposed at a second orientation relative to the longitudinal axis, and optionally, a third portion disposed at a third orientation relative to the longitudinal axis of the leg.
摘要翻译： 带刺的医疗装置包括将一对腿和从每个腿延伸的至少一个倒钩连接的冠。 至少一个倒钩可以限定内表面，其中第一部分相对于腿的纵向轴线以第一取向设置，第二部分相对于纵向轴线以第二取向设置，并且可选地，第三部分设置在 相对于腿的纵向轴线的第三取向。
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公开(公告)号：US20130060348A1
公开(公告)日：2013-03-07
申请号：US13595246
申请日：2012-08-27
CPC分类号： A61L27/34 , A61L27/047 , A61L27/54 , A61L31/022 , A61L31/10 , A61L31/16 , A61L2300/25
摘要： A surgical implant is provided which includes a body and a coating in contact with at least a portion of the body, the body including metallic magnesium, the coating including a hydrogel having an adhesion peptide contained therein. The adhesion peptide may be derived from an extracellular matrix protein and may be covalently bonded to the hydrogel. A method of making a surgical implant includes providing a magnesium based degradable implant body; applying and adhering a functionalized reactive silane based adhesion promoting layer to the implant body; providing a hydrogel monomeric solution having extracellular matrix adhesion peptides incorporated therein; and contacting the hydrogel monomeric solution with the adhesion promoting layer such that the hydrogel polymerizes and bonds to the adhesion promoting layer and encapsulates at least a portion of the implant.
摘要翻译： 提供了一种手术植入物，其包括主体和与主体的至少一部分接触的涂层，所述主体包括金属镁，所述涂层包括其中含有粘附肽的水凝胶。 粘附肽可以衍生自细胞外基质蛋白，并且可以共价键合到水凝胶上。 制造手术植入物的方法包括提供镁基可降解植入体; 将功能化反应性硅烷基粘合促进层施加并粘附到所述植入体上; 提供其中结合有细胞外基质粘附肽的水凝胶单体溶液; 以及使所述水凝胶单体溶液与所述粘附促进层接触，使得所述水凝胶聚合并结合到所述粘附促进层并封装所述植入物的至少一部分。
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公开(公告)号：US08454653B2
公开(公告)日：2013-06-04
申请号：US12727475
申请日：2010-03-19
申请人： Ahmad Robert Hadba , Gerald Hodgkinson , Seth Gleiman , Matthew D. Cohen , Nicholas Maiorino , Timothy D. Kosa , Mark S. Buchter , Michael Primavera
发明人： Ahmad Robert Hadba , Gerald Hodgkinson , Seth Gleiman , Matthew D. Cohen , Nicholas Maiorino , Timothy D. Kosa , Mark S. Buchter , Michael Primavera
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/06166 , A61B17/064 , A61B2017/00526 , A61B2017/00871 , A61B2017/00893 , A61B2017/06176
摘要： A compound barb medical device includes a body portion and at least one barb extending therefrom. The at least one barb defines an inner surface. The inner surface includes a first portion disposed at a first orientation relative to a longitudinal axis of the body portion and a second portion disposed at a second orientation relative to the longitudinal axis. The at least one barb is made from a shape memory material which can be deformed into a temporary shape from a permanent shape. The barb projects from the body portion in a first position relative to the body portion when in the permanent shape and in a second position when in the temporary shape.
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公开(公告)号：US20100211097A1
公开(公告)日：2010-08-19
申请号：US12726815
申请日：2010-03-18
申请人： Ahmad Robert Hadba , Gerald Hodgkinson , Seth Gleiman , Matthew D. Cohen , Nicholas Maiorino , Timothy D. Kosa , Mark S. Buchter , Michael Primavera
发明人： Ahmad Robert Hadba , Gerald Hodgkinson , Seth Gleiman , Matthew D. Cohen , Nicholas Maiorino , Timothy D. Kosa , Mark S. Buchter , Michael Primavera
CPC分类号： A61B17/064 , A61B17/06166 , A61B2017/00004 , A61B2017/00526 , A61B2017/00867 , A61B2017/00893 , A61B2017/06176 , B21G7/02
摘要： Barbed medical devices include a crown interconnecting a pair of legs and at least one barb extending from each of the legs. The at least one barb may define an inner surface with a first portion disposed at a first orientation relative to a longitudinal axis of the leg, a second portion disposed at a second orientation relative to the longitudinal axis, and optionally, a third portion disposed at a third orientation relative to the longitudinal axis of the leg.
摘要翻译： 带刺的医疗装置包括将一对腿和从每个腿延伸的至少一个倒钩连接的冠。 至少一个倒钩可以限定内表面，其中第一部分相对于腿的纵向轴线以第一取向设置，第二部分相对于纵向轴线以第二取向设置，并且可选地，第三部分设置在 相对于腿的纵向轴线的第三取向。
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公开(公告)号：US20100204729A1
公开(公告)日：2010-08-12
申请号：US12727380
申请日：2010-03-19
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00867 , A61B2017/00871 , A61B2017/0477 , A61B2017/06176 , B60R13/02
摘要： A suture including a loop having a tapered end is provided. The suture includes an elongate body including a proximal end and a distal end and a loop integrally formed on the distal end of the elongate body. At least a portion of the loop includes a shape memory polymeric material.
摘要翻译： 提供了包括具有锥形端的环的缝合线。 缝合线包括细长主体，其包括近端和远端以及整体地形成在细长主体的远端上的环。 环的至少一部分包括形状记忆聚合材料。
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公开(公告)号：US20100198257A1
公开(公告)日：2010-08-05
申请号：US12722858
申请日：2010-03-12
IPC分类号： A61B17/04
CPC分类号： A61L17/005 , A61B17/06166 , A61B2017/00336 , A61B2017/00867 , A61B2017/00871 , A61B2017/00889 , A61B2017/00893 , A61B2017/06057 , A61B2017/06176 , A61L17/06 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61L2300/416 , A61L2300/602 , A61L2400/16
摘要： Barbed surgical sutures are provided which include an elongated body and a plurality of barbs extending therefrom. A bioactive agent is disposed within barb angles formed between the barbs and the elongated body. The barbs may be made from a shape memory polymer having a permanent shape which may be deformed to a temporary shape, such that barbs of the suture extend at different barb angles in the different shape configurations. The barb angles of the permanent shape may be greater than the barb angles of the temporary shape, thereby exposing and/or releasing a bioactive agent after placement in tissue.
摘要翻译： 提供了带刺的外科缝合线，其包括细长主体和从其延伸的多个倒钩。 生物活性剂设置在倒钩和细长体之间形成的倒钩角内。 倒钩可以由具有永久形状的形状记忆聚合物制成，其可以变形为临时形状，使得缝线的倒钩在不同形状构造中以不同的倒钩角度延伸。 永久形状的倒刺角可以大于临时形状的倒钩角，从而在放置在组织中之后暴露和/或释放生物活性剂。
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