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    Method and preparations for stabilizing biological materials by drying methods without freezing
    9.
    发明授权
    Method and preparations for stabilizing biological materials by drying methods without freezing 失效
    通过干燥方法稳定生物材料而不冻结的方法和制剂

    公开(公告)号：US07172999B2

    公开(公告)日：2007-02-06

    申请号：US09051918

    申请日：1996-10-24

    申请人： Markus Mattern ,  Gerhard Winter

    发明人： Markus Mattern ,  Gerhard Winter

    IPC分类号： A61K38/18 ,  C07K14/505

    CPC分类号： A61K47/26 ,  A61K38/1816 ,  A61K38/193 ,  A61K38/443 ,  A61K47/183 ,  F26B5/04

    摘要： The present invention concerns processes for the production of dry, partially amorphous products containing biologically active and in particular therapeutically active material which are macroscopically homogeneous substance mixtures, the substance mixtures being selected from at least one substance of each of the groups (i) carbohydrate or zwitterion with a polar residue and derivatives thereof, and (ii) zwitterion with an apolar residue and derivatives thereof, wherein a solution is prepared of the biologically or therapeutically active material and of substances (i) and (ii) and the solution is dried at a product temperature above the freezing point of the solution. In addition the invention concerns new substance mixtures which are obtained by the said process as well as the use thereof in diagnostic or therapeutic methods.

    摘要翻译： 本发明涉及生产含有生物活性的，特别是宏观上均匀的物质混合物的治疗活性物质的干燥，部分无定形产物的方法，所述物质混合物选自每个组的至少一种物质（i）碳水化合物或 具有极性残基及其衍生物的两性离子，和（ii）与非极性残基及其衍生物的两性离子，其中制备生物或治疗活性物质和物质（i）和（ii）的溶液，并将溶液在 产品温度高于溶液的冰点。 此外，本发明涉及通过所述方法获得的新物质混合物以及其在诊断或治疗方法中的用途。