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    Parenteral solvent and a process for the preparation of stable solutions containing same
    1.
    发明授权
    Parenteral solvent and a process for the preparation of stable solutions containing same 失效
    肠胃外溶剂和制备含有它们的稳定溶液的方法

    公开(公告)号：US4344950A

    公开(公告)日：1982-08-17

    申请号：US201509

    申请日：1980-10-28

    申请人： Geza T. Nagy ,  Gabor Szepesi ,  Maria Gazdag

    发明人： Geza T. Nagy ,  Gabor Szepesi ,  Maria Gazdag

    IPC分类号： A61K31/435 ,  A61K9/00 ,  A61K9/08 ,  A61K31/475 ,  A61K47/00 ,  A61P25/28

    CPC分类号： A61K9/0019 ,  A61K31/475

    摘要： A parenteral solvent suitable for injectable solutions of eburnamenines and dihydroeburnamenines is disclosed, said solvent containing a buffer having the ability to buffer the injectable solutions at given pH values, at least one stabilizing agent which includes parenterally acceptable aliphatic alcohols containing one or more hydroxy groups or water-miscible ethers thereof, 30 to 70% by weight water and optional preservatives, anaesthetics, and antioxidants.

    摘要翻译： 公开了一种适用于本戊胺和二氢巴西那宁的可注射溶液的肠胃外溶剂，所述溶剂含有缓冲液，其具有在给定pH值下缓冲注射溶液的能力，至少一种稳定剂，其包含含有一个或多个羟基的肠胃外可接受的脂族醇或 水混溶性醚，30-70％重量水和任选的防腐剂，麻醉剂和抗氧化剂。

    Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them
    2.
    发明授权
    Metal complexes of bis-indole compounds and aqueous pharmaceutical compositions containing them 失效
    双吲哚化合物的金属络合物和含有它们的含水药物组合物

    公开(公告)号：US4684638A

    公开(公告)日：1987-08-04

    申请号：US782492

    申请日：1985-10-01

    申请人： Geza T. Nagy ,  Gabor Szepesi ,  Maria Gazdag ,  Zsofia Papp nee Sziklay ,  Kalman Burger

    发明人： Geza T. Nagy ,  Gabor Szepesi ,  Maria Gazdag ,  Zsofia Papp nee Sziklay ,  Kalman Burger

    IPC分类号： A61K9/00 ,  A61K9/08 ,  A61K31/475 ,  A61K31/555 ,  A61K47/26 ,  A61P35/00 ,  C07D519/04 ,  C07F3/02 ,  C07F3/04 ,  C07F3/06

    CPC分类号： A61K9/0019 ,  A61K31/475 ,  A61K47/26 ,  C07D519/04

    摘要： The invention relates to new aqueous pharmaceutical compositions containing as active ingredient a pharmaceutically acceptable complex of a bis-indole compound with a bi- or multivalent metal ion in a therapeutically effective amount. The invention further relates to complexes formed between a bis-indole compound and a bi- or multivalent metal ion.According to another aspect of the invention there is provided a process for the preparation of a pharmaceutically acceptable metal complex of a bis-indole compound and optionally stable aqueous pharmaceutical compositions containing said metal complex, in which a solution of a bis-indole compound or a pharmaceutically acceptable salt thereof in an aqueous medium is reacted with a non-toxic water soluble salt of a bi- or multivalent metal capable of complexation, at a pH of 3.0 to 6.0, optionally in the presence of or followed by the addition of a conventional pharmaceutical carrier and/or further additive, or, if desired, the obtained complex is isolated.The aqueous pharmaceutical compositions according to the invention have substantially increased stability.

    摘要翻译： 本发明涉及含有治疗有效量的双吲哚化合物与双价或多价金属离子的药学上可接受的复合物作为活性成分的新的含水药物组合物。 本发明还涉及在双吲哚化合物和二价或多价金属离子之间形成的络合物。 根据本发明的另一方面，提供了制备双 - 吲哚化合物和任选的包含所述金属络合物的任选稳定的含水药物组合物的药学上可接受的金属络合物的方法，其中将双吲哚化合物或 其药学上可接受的盐在水性介质中与无毒的水溶性二价或多价金属盐在3.0至6.0的pH下反应，任选在存在或随后加入常规 药物载体和/或另外的添加剂，或者如果需要，分离获得的复合物。 根据本发明的水性药物组合物具有显着提高的稳定性。