-
1.发明授权Correcting an assay image of an array of signals generated from a multiplexed hybridization-mediated assay 有权校正由多重杂交介导的测定产生的信号阵列的测定图像公开(公告)号：US07771939B2
公开(公告)日：2010-08-10
申请号：US11439694
申请日：2006-05-23
Applicant: Ghazala Hashmi , Michael Seul
Inventor： Ghazala Hashmi , Michael Seul
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6827 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/543 , C12Q2563/107 , C12Q2565/501
Abstract: Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.
Abstract translation: 描述了测定设计和测定图像校正的方法，其可用于使用探针对阵列（在一个方面中，其中一个成员与特定突变体互补的突变和多态性）的多重遗传筛选（包括CF相关突变体和多态性） 多态等位基因和另一个成员与相应的野生型等位基因互补），其中探针与编码的颗粒结合（例如，珠粒），其中编码允许鉴定附着的探针。 该方法涉及通过选择探针和扩增子来避免交叉杂交，以及分离某些探针和扩增子的反应，其中超过同源性阈值。 还公开了使用背景图校正荧光图像的方法，其中颗粒还包含光编码系统。
-
公开(公告)号：US20060228744A1
公开(公告)日：2006-10-12
申请号：US11439697
申请日：2006-05-23
Applicant: Ghazala Hashmi , Michael Seul
Inventor： Ghazala Hashmi , Michael Seul
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6827 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/543 , C12Q2563/107 , C12Q2565/501
Abstract: Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.
-
公开(公告)号：US07344841B2
公开(公告)日：2008-03-18
申请号：US11438161
申请日：2006-05-22
Applicant: Ghazala Hashmi , Michael Seul , Joachim Messing
Inventor： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC classification number: C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
Abstract translation: 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
-
4.发明授权Determination of the number of tandem repeat nucleotides using encoded probe-displaying beads 有权使用编码的探针显示珠测定串联重复核苷酸的数目公开(公告)号：US07306918B2
公开(公告)日：2007-12-11
申请号：US11438742
申请日：2006-05-22
Applicant: Ghazala Hashmi , Michael Seul , Joachim Messing
Inventor： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC classification number: C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
Abstract translation: 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
-
5.发明申请Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients 有权用于选择注册捐献者的核酸分型方法用于对输血接受者的交叉匹配公开(公告)号：US20060105370A1
公开(公告)日：2006-05-18
申请号：US11257285
申请日：2005-10-24
Applicant: Ghazala Hashmi , Michael Seul , Marion Reid , Michael Pierce
Inventor： Ghazala Hashmi , Michael Seul , Marion Reid , Michael Pierce
CPC classification number: C12Q1/6881 , C12Q2600/156 , C12Q2600/16
Abstract: Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
Abstract translation: 公开了基于接受者和供体基因型的比较以及等位基因和单体型的潜在组合的遗传交叉匹配的方法和算法。 本发明的方法而不是侧重于表型预测，而是依赖于在接受者和可用供体中鉴定的遗传变异体的比较，其信息优选地将在广泛可用的供体登记册中编译，以最大化分子相容性。 可以基于供体和受体之间的基因型差异的加权临床意义来匹配基因型，使得某些错配比其他错配更可接受。
-
Patent Agency Ranking
6.发明申请Multiplexed analysis of polymorphic loci by concurrent interrogation and enzyme-mediated detection 审中-公开通过同时询问和酶介导检测多态位点的多重分析公开(公告)号：US20080138800A1
公开(公告)日：2008-06-12
申请号：US11438740
申请日：2006-05-22
Applicant: Alice Xiang Li , Ghazala Hashmi , Michael Seul
Inventor： Alice Xiang Li , Ghazala Hashmi , Michael Seul
IPC: C12Q1/68
CPC classification number: C12Q1/6827
Abstract: The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be can be identified.
Abstract translation: 本发明提供用于在一个或多个指定位点识别多态性的方法和过程，而不受位于该指定位点附近的非指定位点的干扰。 提供能够询问这些指定地点的探测器，以确定每个这样的指定地点的组成。 通过本发明的方法，可以鉴定CFTR基因和HLA基因复合体内的一个或多个突变。
-
公开(公告)号：US20070166727A1
公开(公告)日：2007-07-19
申请号：US11438189
申请日：2006-05-22
Applicant: Ghazala Hashmi , Michael Seul , Joachim Messing
Inventor： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC classification number: C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
-
公开(公告)号：US20070128617A1
公开(公告)日：2007-06-07
申请号：US11439695
申请日：2006-05-23
Applicant: Ghazala Hashmi , Michael Seul
Inventor： Ghazala Hashmi , Michael Seul
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6827 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/543 , C12Q2563/107 , C12Q2565/501
Abstract: Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.
Abstract translation: 描述了测定设计和测定图像校正的方法，其可用于使用探针对阵列（在一个方面中，其中一个成员与特定突变体互补的突变和多态性）的多重遗传筛选（包括CF相关突变体和多态性） 多态等位基因和另一个成员与相应的野生型等位基因互补），其中探针与编码的颗粒结合（例如，珠粒），其中编码允许鉴定附着的探针。 该方法涉及通过选择探针和扩增子来避免交叉杂交，以及分离某些探针和扩增子的反应，其中超过同源性阈值。 还公开了使用背景图校正荧光图像的方法，其中颗粒还包含光编码系统。
-
公开(公告)号：US20070048762A1
公开(公告)日：2007-03-01
申请号：US11438161
申请日：2006-05-22
Applicant: Ghazala Hashmi , Michael Seul , Joachim Messing
Inventor： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC classification number: C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
Abstract translation: 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
-
10.发明申请Determination of the number of tandem repeat nucleotides using encoded probe-displaying beads 有权使用编码的探针显示珠测定串联重复核苷酸的数目公开(公告)号：US20060257916A1
公开(公告)日：2006-11-16
申请号：US11438742
申请日：2006-05-22
Applicant: Ghazala Hashmi , Michael Seul , Joachim Messing
Inventor： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC classification number: C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
Abstract: This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
Abstract translation: 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
-
-
-
-
-
-
-
-
-
Search Results
27
records
(took 0.025 seconds)
