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公开(公告)号：US07344841B2
公开(公告)日：2008-03-18
申请号：US11438161
申请日：2006-05-22
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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2.发明授权Determination of the number of tandem repeat nucleotides using encoded probe-displaying beads 有权使用编码的探针显示珠测定串联重复核苷酸的数目公开(公告)号：US07306918B2
公开(公告)日：2007-12-11
申请号：US11438742
申请日：2006-05-22
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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公开(公告)号：US20070166727A1
公开(公告)日：2007-07-19
申请号：US11438189
申请日：2006-05-22
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
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公开(公告)号：US20070048762A1
公开(公告)日：2007-03-01
申请号：US11438161
申请日：2006-05-22
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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5.发明申请Determination of the number of tandem repeat nucleotides using encoded probe-displaying beads 有权使用编码的探针显示珠测定串联重复核苷酸的数目公开(公告)号：US20060257916A1
公开(公告)日：2006-11-16
申请号：US11438742
申请日：2006-05-22
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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公开(公告)号：US07635565B2
公开(公告)日：2009-12-22
申请号：US12113402
申请日：2008-05-01
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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公开(公告)号：US20090264318A1
公开(公告)日：2009-10-22
申请号：US12113402
申请日：2008-05-01
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
IPC分类号： C40B40/08
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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公开(公告)号：US07425416B2
公开(公告)日：2008-09-16
申请号：US11438189
申请日：2006-05-22
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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公开(公告)号：US07157228B2
公开(公告)日：2007-01-02
申请号：US10238439
申请日：2002-09-09
申请人： Ghazala Hashmi , Michael Seul , Joachim Messing
发明人： Ghazala Hashmi , Michael Seul , Joachim Messing
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , B82Y20/00 , C12Q1/6837 , C12Q2565/102 , C12Q2563/149 , C12Q2537/143
摘要： This invention provides compositions and methods for genetic testing of an organism and for correlating the results of the genetic testing with a unique marker that unambiguously identifies the organism. The markers may be internal markers, such as for example single nucleotide polymorphisms (SNPs), short tandem repeats (STRs), or other sites within a genomic locus. Alternatively, the markers may be external, such that they are separately added to the genetic sample before testing.
摘要翻译： 本发明提供了用于生物体的遗传测试的组合物和方法，并且用于将遗传测试的结果与明确识别生物体的唯一标记相关联。 标记可以是内部标记，例如单核苷酸多态性（SNP），短串联重复序列（STR）或基因组基因座内的其他位点。 或者，标记可以是外部的，使得它们在测试之前分开地添加到遗传样品中。
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10.发明授权Correcting an assay image of an array of signals generated from a multiplexed hybridization-mediated assay 有权校正由多重杂交介导的测定产生的信号阵列的测定图像公开(公告)号：US07771939B2
公开(公告)日：2010-08-10
申请号：US11439694
申请日：2006-05-23
申请人： Ghazala Hashmi , Michael Seul
发明人： Ghazala Hashmi , Michael Seul
CPC分类号： C12Q1/6883 , C12Q1/6809 , C12Q1/6827 , C12Q1/6837 , C12Q2600/156 , C12Q2600/16 , Y10S436/80 , Y10S436/805 , Y10T436/143333 , C12Q2565/543 , C12Q2563/107 , C12Q2565/501
摘要： Described are methods of assay design and assay image correction, useful for multiplexed genetic screening for mutations and polymorphisms, including CF-related mutants and polymorphs, using an array of probe pairs (in one aspect, where one member is complementary to a particular mutant or polymorphic allele and the other member is complementary to a corresponding wild type allele), with probes bound to encoded particles (e.g., beads) wherein the encoding allows identification of the attached probe. The methods relate to avoiding cross-hybridization by selection of probes and amplicons, as well as separation of reactions of certain probes and amplicons where a homology threshold is exceeded. Methods of correcting a fluorescent image using a background map, where the particles also contain an optical encoding system, are also disclosed.
摘要翻译： 描述了测定设计和测定图像校正的方法，其可用于使用探针对阵列（在一个方面中，其中一个成员与特定突变体互补的突变和多态性）的多重遗传筛选（包括CF相关突变体和多态性） 多态等位基因和另一个成员与相应的野生型等位基因互补），其中探针与编码的颗粒结合（例如，珠粒），其中编码允许鉴定附着的探针。 该方法涉及通过选择探针和扩增子来避免交叉杂交，以及分离某些探针和扩增子的反应，其中超过同源性阈值。 还公开了使用背景图校正荧光图像的方法，其中颗粒还包含光编码系统。
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