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公开(公告)号：US06893653B2
公开(公告)日：2005-05-17
申请号：US10615623
申请日：2003-07-08
IPC分类号： A61F13/00 , A01N1/02 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/28 , A61K35/12 , A61L27/24 , A61L27/36 , C12N5/08 , A61F38/17
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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公开(公告)号：US06599690B1
公开(公告)日：2003-07-29
申请号：US09450577
申请日：1999-11-30
IPC分类号： A01N102
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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3.发明授权Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix 失效化学处理，无洗涤剂或酶，组织形成无细胞，胶原基质
公开(公告)号：US5993844A
公开(公告)日：1999-11-30
申请号：US853372
申请日：1997-05-08
IPC分类号： A61F13/00 , A01N1/02 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/24 , A61F2/28 , A61K35/12 , A61L27/24 , A61L27/36 , C12N5/08
CPC分类号： A61L27/3687 , A61K35/12 , A61K38/39 , A61L27/24 , A61L27/3695 , A61L2430/40 , Y10S623/917 , Y10S623/92
摘要： The invention is directed to collagenous tissues which have been treated to remove non-collagenous components such as cells, cellular debris, and other extracellular matrix components, such as proteoglycans and glycosaminoglycans, normally found in native tissues. Treatment of the tissue with alkali, chelating agents, acids and salts removes non-collagenous components from the collagenous tissue matrix while controlling the amount of swelling and dissolution so that the resultant collagen matrix retains its structural organization, integrity and bioremodelable properties. The process circumvents the need to use detergents and enzymes which detrimentally affect the cell compatibility, strength and bioremodelability of the collagen matrix. The collagenous tissue matrix is used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及已被处理以去除非胶原成分如胶原组织的细胞，细胞碎片和其它细胞外基质组分，例如通常存在于天然组织中的蛋白聚糖和糖胺聚糖。 用碱处理组织，螯合剂，酸和盐从胶原组织基质中去除非胶原组分，同时控制溶胀和溶解量，使得所得到的胶原基质保持其结构组织，完整性和生物可重构性质。 该方法避免了使用有害地影响胶原基质的细胞相容性，强度和生物可塑性的洗涤剂和酶的需要。 胶原组织基质用于哺乳动物宿主的植入，修复或使用。
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公开(公告)号：US06572650B1
公开(公告)日：2003-06-03
申请号：US09719072
申请日：2001-06-11
IPC分类号： A61F206
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3629 , A61L27/40 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
摘要翻译： 本发明涉及从源自动物来源的清洁的组织材料制备的生物工程化的血管移植物支撑假体。 本发明的生物工程化移植假体是使用保持加工的组织基质的细胞相容性，强度和生物可塑性的方法来制备的。 生物工程移植假体用于哺乳动物宿主植入，修复或使用。
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公开(公告)号：US07214242B2
公开(公告)日：2007-05-08
申请号：US10378178
申请日：2003-03-03
IPC分类号： A61F2/06
CPC分类号： A61L27/3629 , A61L27/24 , A61L27/3641 , A61L27/3687 , A61L27/40 , A61L27/507 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered tubular graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
摘要翻译： 本发明涉及从源自动物来源的清洁的组织材料制备的生物工程管状移植假体。 本发明的生物工程化移植假体是使用保持加工的组织基质的细胞相容性，强度和生物可塑性的方法来制备的。 生物工程移植假体用于哺乳动物宿主植入，修复或使用。
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公开(公告)号：US07041131B2
公开(公告)日：2006-05-09
申请号：US10411816
申请日：2003-04-11
IPC分类号： A61F2/06
CPC分类号： A61L27/507 , A61L27/24 , A61L27/3629 , A61L27/40 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered vascular graft support prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
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公开(公告)号：US07121999B2
公开(公告)日：2006-10-17
申请号：US10378483
申请日：2003-03-03
IPC分类号： A61F2/04
CPC分类号： A61L27/3695 , A61L27/24 , A61L27/3629 , A61L27/3641 , A61L27/3687 , A61L27/3691 , A61L27/40 , B29C53/40 , B29C53/562
摘要： The invention is directed to bioengineered graft prostheses made from two or more superimposed, chemically bonded layers of processed tissue material prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or for use in a mammalian host.
摘要翻译： 本发明涉及由从动物来源的清洁的组织材料制备的由加工的组织材料的两个或更多个叠加的，化学键合的层制成的生物工程接枝假体。 本发明的生物工程化移植假体是使用保持加工的组织基质的细胞相容性，强度和生物可塑性的方法来制备的。 生物工程移植假体用于哺乳动物宿主植入，修复或使用。
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公开(公告)号：US06986735B2
公开(公告)日：2006-01-17
申请号：US10378189
申请日：2003-03-03
IPC分类号： A61F2/02
CPC分类号： A61L27/3629 , A61F2/06 , A61L27/24 , A61L27/3641 , A61L27/3687 , A61L27/40 , A61L27/507 , B29C53/40 , B29C53/562
摘要： The invention is directed to methods of making bioremodelable graft prostheses prepared from cleaned tissue material derived from animal sources. The bioengineered graft prostheses of the invention are prepared using methods that preserve cell compatibility, strength, and bioremodelability of the processed tissue matrix. The bioengineered graft prostheses are used for implantation, repair, or use in a mammalian host.
摘要翻译： 本发明涉及制备从源自动物来源的清洁的组织材料制备的生物可重构的移植假体的方法。 本发明的生物工程化移植假体是使用保持加工的组织基质的细胞相容性，强度和生物可塑性的方法来制备的。 生物工程移植假体用于哺乳动物宿主植入，修复或使用。
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