公开(公告)号：US11793792B2

公开(公告)日：2023-10-24

申请号：US16969246

申请日：2019-02-13

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Barbara Marzani ,  Daniela Pinto ,  Sergio Baroni ,  Ralf Paus ,  Nathan Hawkshaw

IPC分类号： A61K31/427 ,  A61P17/14 ,  A61K8/49 ,  A61Q7/00

CPC分类号： A61K31/427 ,  A61K8/4986 ,  A61P17/14 ,  A61Q7/00

摘要： The present invention relates to the use of iminooxothiazolidine derivatives for preventing or treating hair growth disorders. The iminooxothiazolidine derivatives may be formulated as compositions suitable for either the systemic administration or the local application to the scalp.

公开(公告)号：US11759432B2

公开(公告)日：2023-09-19

申请号：US17057814

申请日：2019-05-21

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Ralf Paus ,  Jeremy Cheret ,  Barbara Marzani ,  Sergio Baroni

IPC分类号： A61K31/045 ,  A61P17/00 ,  A61P29/00 ,  A61K8/34 ,  A61Q19/00 ,  A61Q15/00

CPC分类号： A61K31/045 ,  A61K8/34 ,  A61P17/00 ,  A61P29/00 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/007

摘要： The present invention concerns the use of selected compounds in a cosmetic skincare treatment or in the treatment of certain skin, scalp or mucosal diseases. The invention also provides a composition for topical use incorporating a pharmaceutically or cosmetically effective amount of a compound for preventing or treating skin or mucosal diseases having an inflammatory component or for reducing the redness or irritation of skin or mucosae.

公开(公告)号：US10898419B2

公开(公告)日：2021-01-26

申请号：US16302472

申请日：2017-05-19

申请人： GIULIANI S.P.A.

发明人： Ralf Paus ,  Jeremy Cheret ,  Hanns Hatt ,  Sergio Baroni

IPC分类号： A61K8/34 ,  A61Q7/00 ,  A61K31/045 ,  A61Q5/02

摘要： The invention concerns the use of compounds of general formula (I): (I) wherein: R1 and R2 form together a double bond, or R1 and R2 form together a cyclopropyl group; R3, R4 are the same or different and independently chosen from hydrogen, methyl, or R3 and R4 form together a double bond; R5, R6 are the same or different and independently chosen from hydrogen, methyl; or R5 and R6 form together a double bond, or R5 and R6 form together a cyclopropyl group; R7=methyl, or ethyl; R8=hydrogen, or methyl, for promoting hair growth and/or inhibiting or delaying hair loss in the human scalp, and cosmetic and pharmaceutical compositions suitable for such use.

公开(公告)号：US09944591B2

公开(公告)日：2018-04-17

申请号：US15501997

申请日：2015-08-04

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Anna Benedusi ,  Barbara Marzani ,  Sergio Baroni ,  Elena Pini

IPC分类号： C07C233/49 ,  A61K8/44 ,  A61Q19/00 ,  A61K31/197 ,  A61K31/42

CPC分类号： C07C233/49 ,  A61K8/42 ,  A61K8/44 ,  A61K31/197 ,  A61K31/42 ,  A61K2800/522 ,  A61K2800/74 ,  A61Q17/04 ,  A61Q19/007 ,  A61Q19/08

摘要： The invention relates to the 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid; its use in the therapeutic and cosmetic field for topical application to the skin to achieve a combined antioxidant activity against ROS together with an anti-inflammatory effect and an effect of promoting the production of hyaluronic acid, so as to oppose at the same time the oxidizing action of free radicals and inflammatory effects, in order to preserve the physiological conditions of human epidermis and skin homeostasis and prevent skin aging (anti-aging); the compositions for therapeutic and cosmetic use which comprise 4-((2E,4E,6E)-octa-2,6,4-trienamid)butanoic acid as active ingredient, formulated with excipients for topical use suitable for local administration on the skin.

公开(公告)号：US11273193B2

公开(公告)日：2022-03-15

申请号：US16636291

申请日：2018-08-02

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Ralf Paus ,  Benedetto Grimaldi ,  Barbara Marzani ,  Sergio Baroni

IPC分类号： A61K36/53 ,  A61K9/00 ,  A61K31/132 ,  A61K31/4188 ,  A61K47/02 ,  A61K47/36

摘要： The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.

公开(公告)号：US10550094B2

公开(公告)日：2020-02-04

申请号：US15561611

申请日：2016-03-23

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Anna Benedusi ,  Barbara Marzani ,  Sergio Baroni

IPC分类号： C07D319/06 ,  C07D407/04 ,  A61Q17/00 ,  A61K8/49

摘要： The invention relates to compounds having general formula (I): where R═H, CH2—OH, CH2—O—CO—CH3, CH2—O—CO-Ph (Ph=phenyl) R′═H, CH2—O—CO—CH3, CH2—O—CO-Ph (Ph=phenyl) Ar=phenyl, 3-methoxy-4-hydroxy phenyl, 2-furyl. These are compounds having antioxidant activity against free radicals together with anti-inflammatory activity, the compounds being useful as active ingredients for the preparation of pharmaceutical dermatological or cosmetic compositions for skin care.

公开(公告)号：US09597295B2

公开(公告)日：2017-03-21

申请号：US13761116

申请日：2013-02-06

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Anna Benedusi ,  Sergio Baroni

IPC分类号： A01N37/06 ,  A61K31/22 ,  A61K31/045 ,  A61K31/11 ,  A61K31/231 ,  A61K31/232 ,  A61K8/34 ,  A61K8/36 ,  A61K8/37 ,  A61K31/202 ,  A61K31/23

CPC分类号： A61K31/045 ,  A61K8/342 ,  A61K8/361 ,  A61K8/37 ,  A61K31/11 ,  A61K31/202 ,  A61K31/22 ,  A61K31/23 ,  A61K31/231 ,  A61K31/232 ,  A61P17/00 ,  A61P17/10 ,  A61P17/16 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/08

摘要： The present invention relates to a novel use of compounds having the general formula (I): CH3(—CH═CH)n—R  (I) where n=from 2 to 7, and R is chosen from among: CHO, CH2OH, CH2O—CO—R′, CO—OR′, CO—O(−), where R′ is chosen from among H, the alkyl from C1 to C22, each compound of general formula (I) being used as such or in a mixture, as an active principle in a pharmaceutical or cosmetic composition to improve the human epidermal cell repair activity by means of the production of keratin mediated by the cytokeratins cK-19.

公开(公告)号：US20160213635A1

公开(公告)日：2016-07-28

申请号：US14916935

申请日：2014-09-03

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Anna Benedusi ,  Barbara Marzani ,  Sergio Baroni ,  Mauro Picardo

IPC分类号： A61K31/202 ,  A61K9/00 ,  A61K31/232

CPC分类号： A61K31/202 ,  A61K8/362 ,  A61K8/37 ,  A61K9/0014 ,  A61K31/232 ,  A61K31/235 ,  A61K47/10 ,  A61K47/12 ,  A61K47/26 ,  A61K47/44 ,  A61K2800/522 ,  A61K2800/591 ,  A61Q17/04 ,  A61K2300/00

摘要： The invention relates to compounds of general formula (I): CH3—(CH═CH)n—R (I) wherein n=3, 5, 7; R is selected from —CO—OR′, —CO—O(−), or —CH2—O—CO—R′, R′ being selected from H, C1-C22 alkyl or alkenyl.aryl or aralkyl, or sugars; with the proviso that when R is —CH2—O—CO—R′ and R′ alkyl, said alkyl being selected from C1 to C11; and pharmaceutically acceptable salts thereof, preferably such as sodium, potassium, lysine salts, each compound of general formula (I) being used as such or in admixture with one or more of the other ones, for use in the prevention or treatment of skin cancer resulting from DNA damage produced by UV radiation.

摘要翻译： 本发明涉及通式（I）的化合物：CH 3 - （CH = CH）n -R（I）其中n = 3,5,7; R选自-CO-OR'，-CO-O（ - ）或-CH 2 -O-CO-R'，R'选自H，C 1 -C 22烷基或烯基芳基或芳烷基或糖; 条件是当R是-CH 2 -O-CO-R'和R'烷基时，所述烷基选自C 1至C 11; 和其药学上可接受的盐，优选例如钠，钾，赖氨酸盐，通式（I）的每种化合物原样使用或与一种或多种其它物质混合用于预防或治疗皮肤癌 由UV辐射产生的DNA损伤引起。

公开(公告)号：US20160030365A1

公开(公告)日：2016-02-04

申请号：US14783157

申请日：2014-04-09

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Anna Benedusi ,  Barbara Marzani ,  Sergio Baroni ,  Ralf Paus ,  Yuval Ramot

IPC分类号： A61K31/132 ,  A61Q7/00 ,  A61K35/36 ,  A61Q19/00 ,  A61K8/41 ,  A61K9/00

CPC分类号： A61K31/132 ,  A61K8/41 ,  A61K9/0014 ,  A61K35/36 ,  A61Q7/00 ,  A61Q19/00 ,  A61K2300/00

摘要： The invention concerns the use of compounds of formula (I) R-N1-spermidine, or 1,4-butandiamine,N-(3-amino propyl)-N1—R, (I) H2N—(CH2)3—N1 (R)—(CH2)4—NH2, as such or in the form of pharmaceutically acceptable derivatives, as the active principle in a pharmaceutical or cosmetic composition to preserve and protect epithelial stem cells, and progenitor cells that derive from them, through topical application on the skin or through the use of compounds in cell cultures. Hence, the invention especially concerns the use of compounds of formula (I) to treat cicatricial alopecia, and to stimulate and accelerate tissue repair and healing of both wounds and epidermal scars.

摘要翻译： 本发明涉及式（I）化合物R-N1亚精胺或1,4-丁二胺，N-（3-氨基丙基）-N1-R，（I）H 2 N-（CH 2）3 -Ni R） - （CH 2）4 -NH 2，或其药学上可接受的衍生物的形式作为药物或化妆品组合物中的活性成分，通过局部应用来保存和保护上皮干细胞和源自它们的祖细胞 在皮肤上或通过在细胞培养物中使用化合物。 因此，本发明特别涉及式（I）化合物用于治疗瘢痕性脱发，并刺激和加速伤口和表皮瘢痕两者的组织修复和愈合。

公开(公告)号：US20150202132A1

公开(公告)日：2015-07-23

申请号：US14417598

申请日：2013-07-26

申请人： GIULIANI S.P.A.

发明人： Giammaria Giuliani ,  Ralf Paus ,  Anna Benedusi ,  Barbara Marzani ,  Sergio Baroni

IPC分类号： A61K8/41 ,  A61Q7/00 ,  C07C211/14

CPC分类号： A61K8/41 ,  A61K31/132 ,  A61Q7/00 ,  C07C211/14

摘要： The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R—N1-spermidine, or 1,4-butane-diamine,N-(3-aminopropyl)-N1—R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.

摘要翻译： 本发明涉及一种用于治疗脱发的化妆品或药物组合物，通常用于抵消过度脱发，其包含作为活性成分的式（I）化合物R-N1-亚精胺或1,4-丁烷二胺， N-（3-氨基丙基）-N1-R。 通式（I）的化合物根据本发明的目的是有活性的，并且也足够稳定以允许有效应用于头皮上的局部使用，而不会潜在地转化为不再活化的不同物质，如 氧化的结果。