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    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    3.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 审中-公开
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20140194598A1

    公开(公告)日：2014-07-10

    申请号：US14178360

    申请日：2014-02-12

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/705 ,  C07K16/28 ,  A61K47/48

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    4.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20100136575A1

    公开(公告)日：2010-06-03

    申请号：US12701119

    申请日：2010-02-05

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： G01N33/53 ,  C07K16/00 ,  C12N5/16

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    BSL3 polypeptides
    5.
    发明授权
    BSL3 polypeptides 有权
    BSL3多肽

    公开(公告)号：US07723479B2

    公开(公告)日：2010-05-25

    申请号：US11900026

    申请日：2007-09-06

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/705

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION
    6.
    发明申请
    B7-RELATED NUCLEIC ACIDS AND POLYPEPTIDES USEFUL FOR IMMUNOMODULATION 有权
    B7相关核酸和多肽可用于免疫调节

    公开(公告)号：US20120329990A1

    公开(公告)日：2012-12-27

    申请号：US13331540

    申请日：2011-12-20

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N. Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K14/435 ,  C07H21/04

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    B-7 related nucleic acids and polypeptides useful for immunomodulation
    8.
    发明申请
    B-7 related nucleic acids and polypeptides useful for immunomodulation 有权
    可用于免疫调节的B-7相关核酸和多肽

    公开(公告)号：US20090215995A1

    公开(公告)日：2009-08-27

    申请号：US11900026

    申请日：2007-09-06

    申请人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N, Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    发明人： Glen Eugene Mikesell ,  Han Chang ,  Joshua N, Finger ,  Guchen Yang ,  Robert James Peach ,  Henry Shen

    IPC分类号： C07K19/00 ,  C07K14/47

    CPC分类号： C07K14/70532 ,  A61K38/00 ,  C07K16/2827 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  Y10S435/81

    摘要： The present invention provides nucleic acids encoding B7-related factors that modulate the activation of immune or inflammatory response cells, such as T-cells. Also provided are expression vectors and fusion constructs comprising nucleic acids encoding B7-related polypeptides, including BSL1, BSL2, and BSL3. The present invention further provides isolated B7-related polypeptides, isolated fusion proteins comprising B7-related polypeptides, and antibodies that are specifically reactive with B7-related polypeptides, or portions thereof. In addition, the present invention provides assays utilizing B7-related nucleic acids, polypeptides, or peptides. The present invention further provides compositions of B7-related nucleic acids, polypeptides, fusion proteins, or antibodies that are useful for the immunomodulation of a human or animal subject.

    摘要翻译： 本发明提供编码调节免疫或炎性反应细胞如T细胞活化的B7相关因子的核酸。 还提供了包含编码B7相关多肽（包括BSL1，BSL2和BSL3）的核酸的表达载体和融合构建体。 本发明进一步提供分离的B7相关多肽，分离的包含B7相关多肽的融合蛋白，以及与B7相关多肽特异性反应的抗体或其部分。 此外，本发明提供利用B7相关核酸，多肽或肽的测定法。 本发明还提供可用于人或动物受试者的免疫调节的B7相关核酸，多肽，融合蛋白或抗体的组合物。

    DNA molecules encoding human CLAX proteins and their soluble fusion proteins
    10.
    发明授权
    DNA molecules encoding human CLAX proteins and their soluble fusion proteins 有权
    编码人类CLAX蛋白的DNA分子及其可溶性融合蛋白

    公开(公告)号：US06455683B1

    公开(公告)日：2002-09-24

    申请号：US09531056

    申请日：2000-03-20

    申请人： Guchen Yang ,  Xiaorong Chen ,  Patricia M. Davis ,  Peter A. Kiener

    发明人： Guchen Yang ,  Xiaorong Chen ,  Patricia M. Davis ,  Peter A. Kiener

    IPC分类号： C07H2102

    CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K14/4726 ,  C07K14/7056 ,  C07K2319/00

    摘要： Isolated novel cDNA sequences encoding a human C-type lectin and three homologues are provided. They are referred to herein as “CLAX” (C-type Lectin, Activation Expressed) proteins. The invention also includes methods of using the nucleic acid sequences, polypeptides encoded by the nucleic acid sequences disclosed herein, fusion proteins having all or a portion (e.g., an extracellular region) of the CLAX proteins, antibodies specific for the novel CLAXs, ligands and inhibitors for the novel CLAXs. The genes of CLAX are specifically expressed in lymphoid tissues and activated T lymphocytes but not resting T lymphocytes. The invention concerns the utility in pharmaceutical compositions for the prevention and treatment of infectious, inflammatory and allergic diseases.

    摘要翻译： 提供了编码人C型凝集素和三个同系物的分离的新型cDNA序列。 它们在本文中称为“CLAX”（C型凝集素，激活表达的）蛋白质。 本发明还包括使用核酸序列的方法，由本文公开的核酸序列编码的多肽，具有CLAX蛋白的全部或部分（例如细胞外区域）的融合蛋白，对于新型CLAXs具有特异性的抗体，配体和 新型CLAXs的抑制剂。 CLAX的基因在淋巴组织和活化的T淋巴细胞中特异性表达，但不是休息的T淋巴细胞。 本发明涉及用于预防和治疗感染性，炎性和过敏性疾病的药物组合物中的应用。