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公开(公告)号:US07375198B2
公开(公告)日:2008-05-20
申请号:US10418414
申请日:2003-04-18
申请人: Glenn Hugh McGall , Charles Garrett Miyada , Maureen T. Cronin , Jennifer Dee Tan , Mark S. Chee
发明人: Glenn Hugh McGall , Charles Garrett Miyada , Maureen T. Cronin , Jennifer Dee Tan , Mark S. Chee
CPC分类号: C40B80/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6832 , C40B40/06 , C40B60/14
摘要: Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.
摘要翻译: 提供了连接到固体底物的寡核苷酸类似物阵列和与使用相关的方法。 寡核苷酸类似物与具有比相应的未修饰寡核苷酸更高或更低特异性的核酸杂交。 包含核苷酸类似物的靶核酸与寡核苷酸和寡核苷酸类似物阵列结合。
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公开(公告)号:US6156501A
公开(公告)日:2000-12-05
申请号:US630427
申请日:1996-04-03
申请人: Glenn Hugh McGall , Charles Garrett Miyada , Maureen T. Cronin , Jennifer Dee Tan , Mark S. Chee
发明人: Glenn Hugh McGall , Charles Garrett Miyada , Maureen T. Cronin , Jennifer Dee Tan , Mark S. Chee
CPC分类号: C07H21/00
摘要: Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.
摘要翻译: 提供了连接到固体底物的寡核苷酸类似物阵列和与使用相关的方法。 寡核苷酸类似物与具有比相应的未修饰寡核苷酸更高或更低特异性的核酸杂交。 包含核苷酸类似物的靶核酸与寡核苷酸和寡核苷酸类似物阵列结合。
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公开(公告)号:US20090286690A1
公开(公告)日:2009-11-19
申请号:US12124061
申请日:2008-05-20
申请人: Glenn Hugh McGall , Charles Garrett Miyada , Maureen T. Cronin , Jennifer Dee Tan , Mark S. Chee
发明人: Glenn Hugh McGall , Charles Garrett Miyada , Maureen T. Cronin , Jennifer Dee Tan , Mark S. Chee
IPC分类号: C40B30/04
CPC分类号: C40B80/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6832 , C40B40/06 , C40B60/14
摘要: Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.
摘要翻译: 提供了连接到固体底物的寡核苷酸类似物阵列和与使用相关的方法。 寡核苷酸类似物与具有比相应的未修饰寡核苷酸更高或更低特异性的核酸杂交。 包含核苷酸类似物的靶核酸与寡核苷酸和寡核苷酸类似物阵列结合。
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公开(公告)号:US07794943B2
公开(公告)日:2010-09-14
申请号:US12124061
申请日:2008-05-20
CPC分类号: C40B80/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6832 , C40B40/06 , C40B60/14
摘要: Oligonucleotide analogue arrays attached to solid substrates and methods related to the use thereof are provided. The oligonucleotide analogues hybridize to nucleic acids with either higher or lower specificity than corresponding unmodified oligonucleotides. Target nucleic acids which comprise nucleotide analogues are bound to oligonucleotide and oligonucleotide analogue arrays.
摘要翻译: 提供了连接到固体底物的寡核苷酸类似物阵列和与使用相关的方法。 寡核苷酸类似物与具有比相应的未修饰寡核苷酸更高或更低特异性的核酸杂交。 包含核苷酸类似物的靶核酸与寡核苷酸和寡核苷酸类似物阵列结合。
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5.Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis 失效
标题翻译: 核酸探针阵列及其用于检测囊性纤维化的方法公开(公告)号:US6027880A
公开(公告)日:2000-02-22
申请号:US544381
申请日:1995-10-10
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , Macdonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , Macdonald S. Morris , Edward L. Sheldon
CPC分类号: C07H21/00 , B01J19/0046 , B82Y30/00 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q1/6883 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , C07B2200/11 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14
摘要: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译: 本发明提供了固定化探针的阵列,以及采用阵列的方法,用于检测CFTR基因中的突变。
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公开(公告)号:US07115364B1
公开(公告)日:2006-10-03
申请号:US08510521
申请日:1995-08-02
申请人: Mark Chee , Maureen T. Cronin , Stephen P. A. Fodor , Thomas R. Gingeras , Xiaohua C. Huang , Earl A. Hubbell , Robert J. Lipshutz , Peter E. Lobban , Charles Garrett Miyada , Macdonald S. Morris , Nila Shah , Edward L. Sheldon
发明人: Mark Chee , Maureen T. Cronin , Stephen P. A. Fodor , Thomas R. Gingeras , Xiaohua C. Huang , Earl A. Hubbell , Robert J. Lipshutz , Peter E. Lobban , Charles Garrett Miyada , Macdonald S. Morris , Nila Shah , Edward L. Sheldon
CPC分类号: C12Q1/6869 , C12Q1/6886 , Y02A50/54
摘要: The invention provides chips of immobilized probes, and methods employing the chips, for comparing a reference polynucleotide sequence of known sequence with a target sequence showing substantial similarity with the reference sequence, but differing in the presence of e.g., mutations.
摘要翻译: 本发明提供了固定化探针的芯片,以及使用该芯片的方法,用于将已知序列的参考多核苷酸序列与显示与参考序列基本相似的靶序列进行比较,但在例如突变的存在下不同。
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公开(公告)号:US20080261832A1
公开(公告)日:2008-10-23
申请号:US11506176
申请日:2006-08-18
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC分类号: C12Q1/6874 , C12Q1/6886
摘要: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译: 本发明提供了固定化探针的阵列,以及采用阵列的方法,用于检测CFTR基因中的突变。
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8.
公开(公告)号:US20120329677A9
公开(公告)日:2012-12-27
申请号:US11506176
申请日:2006-08-18
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P.A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC分类号: C12Q1/6874 , C12Q1/6886
摘要: The invention provides arrays of immobilized probes, and methods employing the arrays, for detecting mutations in the CFTR gene.
摘要翻译: 本发明提供了固定化探针的阵列,以及采用阵列的方法,用于检测CFTR基因中的突变。
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9.
公开(公告)号:US07399584B2
公开(公告)日:2008-07-15
申请号:US09510378
申请日:2000-02-22
申请人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
发明人: Maureen T. Cronin , Charles Garrett Miyada , Earl A. Hubbell , Mark Chee , Stephen P. A. Fodor , Xiaohua C. Huang , Robert J. Lipshutz , Peter E. Lobban , MacDonald S. Morris , Edward L. Sheldon
CPC分类号: C07H21/00 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C12Q1/6827 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14 , C12Q2565/513
摘要: The invention provides methods of comparing a target nucleic acid with a reference nucleic acid using nucleic acid arrays.
摘要翻译: 本发明提供了使用核酸阵列比较靶核酸与参考核酸的方法。
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公开(公告)号:US6045996A
公开(公告)日:2000-04-04
申请号:US648709
申请日:1996-05-16
申请人: Maureen T. Cronin , Charles Garrett Miyada , Mark Trulson , Thomas R. Gingeras , Glenn McGall , Claire Robinson , Michelle Oval
发明人: Maureen T. Cronin , Charles Garrett Miyada , Mark Trulson , Thomas R. Gingeras , Glenn McGall , Claire Robinson , Michelle Oval
CPC分类号: B01J19/0046 , B82Y30/00 , C07H21/00 , C12Q1/6827 , C12Q1/6832 , C12Q1/6837 , C12Q1/6874 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , C07B2200/11 , C40B40/06 , C40B60/14
摘要: This invention provides methods of performing nucleic acid hybridization assays on high-density substrate-bound oligonucleotide arrays involving including in the hybridization mixture an isostabilizing agent, a denaturing agent or a renaturation accelerant.
摘要翻译: 本发明提供了在高密度底物结合寡核苷酸阵列上进行核酸杂交测定的方法,包括在杂交混合物中包含等稳化剂,变性剂或复性促进剂。
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