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1.再颁专利公开(公告)号：USRE41328E1
公开(公告)日：2010-05-11
申请号：US12199215
申请日：2008-08-27
申请人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
发明人： Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer , Daniel L. Lohse , Robert J. Linhardt
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
摘要翻译： 不含裂解酶活性的纯化肝素酶I，II和III分别通过培养肝炎黄杆菌而产生，分子量分别为42,400,84,100,70,800。 已经确定了肝素酶的动力学性质以及优化其活性和稳定性的条件。
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2.发明授权
公开(公告)号：US5389539A
公开(公告)日：1995-02-14
申请号：US983367
申请日：1992-11-30
申请人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
发明人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
IPC分类号： G01N33/573 , C07K16/40 , C12N9/88 , C12P19/26 , C12P21/08 , C12R1/20 , C12R1/91 , C12N9/00 , C12N1/20 , C12N9/52
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A purified heparinase I, II and III free of lyase activity and each having a molecular weight of 42,800 84,100, 70,800, respectively, are produced by culturing Flavobacterium heparinum. The kinetic properties of the heparinases have been determined as well as the conditions to optimize their activity and stability.
摘要翻译： 不含裂解酶活性的纯化的肝素酶I，II和III分别通过培养肝素肝素而产生，分子量分别为42,600 84,100,70,800。 已经确定了肝素酶的动力学性质以及优化其活性和稳定性的条件。
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3.再颁专利Purification, composition and specificity of Heparinase I, II, and III from Flavobacterium heparinum 有权来自肝炎黄杆菌的肝素酶I，II和III的纯化，组成和特异性公开(公告)号：USRE41461E1
公开(公告)日：2010-07-27
申请号：US12199157
申请日：2008-08-27
申请人： Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
发明人： Daniel L. Lohse , Robert J. Linhardt , Ramnath Sasisekharan , Charles L. Cooney , Robert S. Langer
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Mono-clonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
摘要翻译： 本文公开了将来自肝素肝素的所有三种肝素裂解酶同时纯化到表观均一性的单一可再现方案。 已经确定了肝素裂解酶的动力学性质以及优化其活性和稳定性的条件。 还描述了对三种肝素酶的单克隆抗体，并且其可用于肝素酶的检测，分离和表征。
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4.发明授权
公开(公告)号：US5569600A
公开(公告)日：1996-10-29
申请号：US378789
申请日：1995-01-26
申请人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
发明人： Ramnath Sasisekharan , Daniel L. Lohse , Charles L. Cooney , Robert J. Linhardt , Robert S. Langer
IPC分类号： G01N33/573 , C07K16/40 , C12N9/88 , C12P19/26 , C12P21/08 , C12R1/20 , C12R1/91 , C12N9/00 , C12N1/20 , C12N9/52
CPC分类号： C12N9/88 , Y10S435/822 , Y10S435/85
摘要： A single, reproducible scheme to simultaneously purify all three of the heparin lyases from F. heparinum to apparent homogeneity is disclosed herein. The kinetic properties of the heparin lyases have been determined as well as the conditions to optimize their activity and stability. Monoclonal antibodies to the three heparinases are also described and are useful for detection, isolation and characterization of the heparinases.
摘要翻译： 本文公开了将来自肝素肝素的所有三种肝素裂解酶同时纯化到表观均一性的单一可再现方案。 已经确定了肝素裂解酶的动力学性质以及优化其活性和稳定性的条件。 还描述了三种肝素酶的单克隆抗体，并且其可用于肝素酶的检测，分离和表征。
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公开(公告)号：US4396762A
公开(公告)日：1983-08-02
申请号：US295914
申请日：1981-08-24
CPC分类号： A61K31/715 , C08B37/0078 , Y10S435/85
摘要： There is disclosed a heparin product obtained by degradation of heparin with heparinase from Flavobacterium heparinum (ATCC 13125) or mutants thereof having activity to reduce the coagulation activity of factor X while not effecting the coagulation activity of thrombin.
摘要翻译： 公开了通过肝素从肝素黄素（ATCC13125）或其突变体用肝素酶降解获得的肝素产物，其具有降低因子X的凝血活性而不影响凝血酶凝血活性的活性。
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公开(公告)号：US4906474A
公开(公告)日：1990-03-06
申请号：US613001
申请日：1984-05-21
申请人： Robert S. Langer , Howard Rosen , Robert J. Linhardt , Kam Leong
发明人： Robert S. Langer , Howard Rosen , Robert J. Linhardt , Kam Leong
摘要： A composition of matter suitable for implantation in the body to effect zero order drug release comprising a drug and a polymer of the formula: ##STR1## wherein R and R' can be the same or different and are hydrophobic organic linkages and n and m are integers of 1 or greater.
摘要翻译： 适于植入体内以实现零级药物释放的物质组合物，其包含药物和下式的聚合物：其中R和R'可以相同或不同，并且是疏水性有机键，并且n和m是 1或更大的整数。
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公开(公告)号：US20120322114A1
公开(公告)日：2012-12-20
申请号：US13417641
申请日：2012-03-12
申请人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
发明人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
CPC分类号： C12P19/64
摘要： Heparosan is sulfated at the iduronic acid residue by providing a reaction mixture comprising C5 epimerase to convert glucuronic acid to iduronic acid, and at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS).
摘要翻译： 通过提供包含C5差向异构酶以将葡萄糖醛酸转化为艾杜糖醛酸的反应混合物和至少一种O-磺基转移酶（OST）酶和3'-磷酸腺苷5'-磷酸硫酸酯（PAPS），将Heparosan硫酸化在艾杜糖醛酸残基上。
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8.发明申请公开(公告)号：US20100239673A1
公开(公告)日：2010-09-23
申请号：US11497838
申请日：2006-08-01
IPC分类号： A61K9/14 , C07H3/00 , C08B37/10 , A61K31/727 , A61K31/715 , C07K14/00 , A61P13/12
CPC分类号： A61K9/5161 , A61K9/5192
摘要： The invention provides blood compatible nanomaterials, biomaterials prepared therewith and blood compatible medical devices fabricated using the biomaterials of the invention. The invention further provides methods of making and using the nanomaterials, biomaterials and medical devices of the invention for the diagnosis, prevention and treatment of medical conditions. The invention further provides methods of using room temperature ionic liquids to make blood compatible nanomaterials.
摘要翻译： 本发明提供与血液相容的纳米材料，其制备的生物材料和使用本发明的生物材料制造的与血液相容的医疗装置。 本发明还提供了制造和使用本发明的纳米材料，生物材料和医疗装置用于诊断，预防和治疗医疗状况的方法。 本发明还提供使用室温离子液体制备血液相容的纳米材料的方法。
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公开(公告)号：US06184196B2
公开(公告)日：2001-02-06
申请号：US09321225
申请日：1999-05-27
申请人： Helene G. Bazin , Tulay Polat , Robert J. Linhardt
发明人： Helene G. Bazin , Tulay Polat , Robert J. Linhardt
IPC分类号： C07H1100
摘要： The invention relates to the synthesis of sulfonated sucrose compounds, surfactants and intermediate cyclic sulfates.
摘要翻译： 本发明涉及磺化蔗糖化合物，表面活性剂和中间体环状硫酸盐的合成。
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公开(公告)号：US09061904B2
公开(公告)日：2015-06-23
申请号：US13157758
申请日：2011-06-10
申请人： Minoru Miyauchi , Jianjun Miao , Trevor J. Simmons , Jong-Won Lee , Thomas V. Doherty , Jonathan S. Dordick , Robert J. Linhardt
发明人： Minoru Miyauchi , Jianjun Miao , Trevor J. Simmons , Jong-Won Lee , Thomas V. Doherty , Jonathan S. Dordick , Robert J. Linhardt
IPC分类号： B23B9/04 , B29C47/04 , D02G3/00 , B82Y30/00 , D01D5/00 , D01F1/09 , D01F8/02 , H01G9/02 , H01G11/52
CPC分类号： B82Y30/00 , D01D5/0007 , D01F1/09 , D01F2/02 , D01F8/02 , H01G9/02 , H01G11/52 , Y02E60/13 , Y10T428/2918
摘要： Embodiments of the invention provide a cellulose-sheathed carbon nanotube fiber. One aspect of the invention provides a sheathed nanotube fiber comprising: a carbon nanotube fiber; and a cellulose sheath extending co-axially along at least a first portion of a length of the carbon nanotube fiber. Another aspect of the invention provides a method of forming a sheathed carbon nanotube fiber, the method comprising: co-electrospinning a carbon nanotube fiber gel core within a cellulose solution sheath.
摘要翻译： 本发明的实施方案提供了一种纤维素包覆的碳纳米管纤维。 本发明的一个方面提供一种护套纳米管纤维，其包含：碳纳米管纤维; 以及沿所述碳纳米管纤维的长度的至少第一部分同轴延伸的纤维素护套。 本发明的另一方面提供了一种形成护套碳纳米管纤维的方法，所述方法包括：在纤维素溶液鞘内共同静电纺丝碳纳米管纤维凝胶芯。
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