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公开(公告)号：US11530191B2
公开(公告)日：2022-12-20
申请号：US17026690
申请日：2020-09-21
发明人： Brian W. Metcalf , Zhe Li , Qing Xu , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC分类号： C07D401/04 , C07D213/30 , A61K31/445 , A61K31/5375 , C07D401/14 , C07D405/14 , C07D401/12 , C07D471/04 , C07D257/04 , C07D487/04 , C07D231/56 , C07D211/62 , C07D213/64 , C07C65/30 , C07F7/08 , A61K8/49 , C07D211/70 , C07D213/69 , C07D227/08 , C07D405/04
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US09802900B2
公开(公告)日：2017-10-31
申请号：US14207289
申请日：2014-03-12
发明人： Zhe Li , Stephen L. Gwaltney, II , Jason R. Harris
IPC分类号： A61K31/497 , A61K31/4427 , A61K31/4162 , C07D231/56 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
CPC分类号： C07D231/56 , A61K31/4162 , A61K31/4427 , A61K31/497 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US11236109B2
公开(公告)日：2022-02-01
申请号：US16357148
申请日：2019-03-18
发明人： Zhe Li , Qing Xu , Brian W. Metcalf , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC分类号： C07D401/04 , C07D498/08 , C07D491/107 , C07D213/74 , C07D403/04
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US09957250B2
公开(公告)日：2018-05-01
申请号：US14980890
申请日：2015-12-28
IPC分类号： C07D401/04 , C07F9/6558
CPC分类号： C07D401/04 , C07F9/65583
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US20140275181A1
公开(公告)日：2014-09-18
申请号：US13815874
申请日：2013-03-15
发明人： Jason R. Harris , Qing Xu , Zhe Li
IPC分类号： C07D401/04
CPC分类号： C07D498/08 , C07D213/74 , C07D401/04 , C07D403/04 , C07D491/107
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US20230322704A1
公开(公告)日：2023-10-12
申请号：US17981140
申请日：2022-11-04
发明人： Brian W. Metcalf , Zhe Li , Qing Xu , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D401/12 , C07D471/04 , C07D257/04 , C07D213/30 , C07D487/04 , C07D231/56 , C07D211/62 , C07D213/64 , C07C65/30 , C07F7/08 , A61K8/49 , A61K31/445 , A61K31/5375 , C07D211/70 , C07D213/69 , C07D227/08 , C07D405/04
CPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D401/12 , C07D471/04 , C07D257/04 , C07D213/30 , C07D487/04 , C07D231/56 , C07D211/62 , C07D213/64 , C07C65/30 , C07F7/0812 , A61K8/4913 , A61K31/445 , A61K31/5375 , C07D211/70 , C07D213/69 , C07D227/08 , C07D405/04
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US20220119407A1
公开(公告)日：2022-04-21
申请号：US17567605
申请日：2022-01-03
发明人： Zhe Li , Qing Xu , Brian W. Metcalf , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC分类号： C07D498/08 , C07D213/74 , C07D401/04 , C07D403/04 , C07D491/107
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US10100040B2
公开(公告)日：2018-10-16
申请号：US14776715
申请日：2014-03-10
发明人： Zhe Li , Qing Xu , Brian W. Metcalf , Stephen L. Gwaltney, II , Jason R. Harris , Calvin W. Yee
IPC分类号： C07D405/04 , C07D401/04 , A61K8/49 , C07D403/04 , C07D413/04
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US09604999B2
公开(公告)日：2017-03-28
申请号：US13815874
申请日：2013-03-15
发明人： Jason R. Harris , Qing Xu , Zhe Li
IPC分类号： C07D401/04 , C07D498/08 , C07D213/74 , C07D403/04 , C07D491/107
CPC分类号： C07D498/08 , C07D213/74 , C07D401/04 , C07D403/04 , C07D491/107
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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公开(公告)号：US20140274961A1
公开(公告)日：2014-09-18
申请号：US13815810
申请日：2013-03-15
IPC分类号： C07D401/04 , C07F9/6558
CPC分类号： C07D401/04 , C07F9/65583
摘要： Provide herein are compounds and pharmaceutical compositions suitable as modulators of hemoglobin, methods and intermediates for their preparation, and methods for their use in treating disorders mediated by hemoglobin and disorders that would benefit from tissue and/or cellular oxygenation.
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