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公开(公告)号：US08859738B2
公开(公告)日：2014-10-14
申请号：US12990119
申请日：2009-03-03
IPC分类号： C12P21/08
CPC分类号： C07K16/32 , A61K2039/507 , C07K16/005 , C07K16/2863 , C07K16/30 , C07K16/40 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6 OkD, specifically binding to a cell surface target with a binding affinity of Kd
摘要翻译： 本发明涉及分子量高达6个OkD的细胞毒性模块抗体，特异性结合具有Kd <10-8M的结合亲和力的细胞表面靶标，产生这种抗体的方法及其作为治疗剂的用途。
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公开(公告)号：US20110046355A1
公开(公告)日：2011-02-24
申请号：US12990119
申请日：2009-03-03
申请人： Gottfried Himmler , Geert Mudde , Anton Bauer , Gerda Redl
发明人： Gottfried Himmler , Geert Mudde , Anton Bauer , Gerda Redl
CPC分类号： C07K16/32 , A61K2039/507 , C07K16/005 , C07K16/2863 , C07K16/30 , C07K16/40 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/53 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92
摘要： The invention relates to a cytotoxic modular antibody with a molecular weight of up to 6 OkD, specifically binding to a cell surface target with a binding affinity of Kd
摘要翻译： 本发明涉及分子量高达6个OkD的细胞毒性模块抗体，特异性结合具有Kd <10-8M的结合亲和力的细胞表面靶标，产生这种抗体的方法及其作为治疗剂的用途。
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公开(公告)号：US08921279B2
公开(公告)日：2014-12-30
申请号：US12666618
申请日：2008-06-26
CPC分类号： C07K16/005 , C07K16/32 , C07K2317/52 , C07K2317/569 , C07K2318/10 , C40B30/04 , G01N33/6857 , G01N2333/70535
摘要： The present invention relates to a method of preparing a genetic package displaying oligomers of modular antibody domains binding to a target and to a scaffold ligand as well as to vectors and libraries of genetic packages produced thereby. The invention further relates to methods of selecting suitable linker sequences for use in such oligomer display.
摘要翻译： 本发明涉及制备显示结合靶标和支架配体的模块抗体结构域的寡聚体以及由此产生的遗传包装的载体和文库的遗传包的方法。 本发明还涉及选择用于这种低聚物显示的合适的接头序列的方法。
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公开(公告)号：US20100184615A1
公开(公告)日：2010-07-22
申请号：US12666618
申请日：2008-06-26
CPC分类号： C07K16/005 , C07K16/32 , C07K2317/52 , C07K2317/569 , C07K2318/10 , C40B30/04 , G01N33/6857 , G01N2333/70535
摘要： The present invention relates to a method of preparing a genetic package displaying oligomers of modular antibody domains binding to a target and to a scaffold ligand as well as to vectors and libraries of genetic packages produced thereby. The invention further relates to methods of selecting suitable linker sequences for use in such oligomer display.
摘要翻译： 本发明涉及制备显示结合靶标和支架配体的模块抗体结构域的寡聚体以及由此产生的遗传包装的载体和文库的遗传包的方法。 本发明还涉及选择用于这种低聚物显示的合适的接头序列的方法。
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公开(公告)号：US20100029497A1
公开(公告)日：2010-02-04
申请号：US12307569
申请日：2007-07-05
申请人： Gottfried Himmler , Gerda Redl , Florian Ruker
发明人： Gottfried Himmler , Gerda Redl , Florian Ruker
CPC分类号： C12N15/1037 , C07K16/00 , C07K16/005 , C07K16/1045 , C07K16/1063 , C07K16/16 , C07K16/18 , C07K16/241 , C07K16/283 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/22 , C07K2317/55 , C07K2317/622
摘要： The present invention relates to a method for engineering an immunoglobulin comprising a variable domain and at least one modification in at least two structural loops of said immunoglobulin and determining the binding of said immunoglobulin to an epitope of an antigen, wherein the unmodified immunoglobulin does not significantly bind to said epitope, comprising the steps of: providing a nucleic acid encoding an immunoglobulin comprising at least two structural loops, modifying at least one nucleotide residue of each of said structural loops, transferring said modified nucleic acid in an expression System, expressing said modified immunoglobulin, contacting the expressed modified immunoglobulin with an epitope, and determining whether said modified immunoglobulin binds to said epitope, immunoglobulins produced by such a method and libraries of immunoglobulins.
摘要翻译： 本发明涉及一种用于工程化免疫球蛋白的方法，所述免疫球蛋白包含所述免疫球蛋白的至少两个结构环中的可变结构域和至少一个修饰，并确定所述免疫球蛋白与抗原表位的结合，其中未修饰的免疫球蛋白不显着 包括以下步骤：提供编码包含至少两个结构环的免疫球蛋白的核酸，修饰每个所述结构环的至少一个核苷酸残基，将表达系统中的所述修饰的核酸转移，表达所述修饰的 免疫球蛋白，将表达的修饰的免疫球蛋白与表位接触，并确定所述修饰的免疫球蛋白是否结合所述表位，通过这种方法产生的免疫球蛋白和免疫球蛋白的文库。
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公开(公告)号：US20080095783A1
公开(公告)日：2008-04-24
申请号：US11571983
申请日：2004-07-14
申请人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Gunter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： A61K39/395 , A61P43/00 , C07K16/18
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译： 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段，其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。
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公开(公告)号：US20060127403A1
公开(公告)日：2006-06-15
申请号：US10524520
申请日：2003-07-31
申请人： Hans Loibner , Gottfried Himmler , Hellmut Samonigg , Eugen Stermetz , Andreas Hauer , Gerda Redl
发明人： Hans Loibner , Gottfried Himmler , Hellmut Samonigg , Eugen Stermetz , Andreas Hauer , Gerda Redl
IPC分类号： A61K39/395
CPC分类号： A61K39/39533 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/734
摘要： The invention relates to the use of a preparation based on an antibody directed against a tumor-associated antigen, for producing a medicament for the intra-operative treatment of tumor patients, in particular for the prophylactic treatment to prevent the dissemination of tumor cells. The invention further relates to a kit for the intra-operative treatment of tumor patients, comprising the medicament and means for diagnostically determining malignant tumor cells.
摘要翻译： 本发明涉及基于针对肿瘤相关抗原的抗体的制剂的用途，用于产生用于手术中治疗肿瘤患者的药物，特别是用于预防性治疗以预防肿瘤细胞的传播。 本发明还涉及用于肿瘤患者的术中治疗的试剂盒，其包含用于诊断性地测定恶性肿瘤细胞的药物和手段。
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公开(公告)号：US09133274B2
公开(公告)日：2015-09-15
申请号：US12307569
申请日：2007-07-05
CPC分类号： C12N15/1037 , C07K16/00 , C07K16/005 , C07K16/1045 , C07K16/1063 , C07K16/16 , C07K16/18 , C07K16/241 , C07K16/283 , C07K16/32 , C07K16/40 , C07K2317/21 , C07K2317/22 , C07K2317/55 , C07K2317/622
摘要： A method for engineering an immunoglobulin having a variable domain and at least one modification in at least two structural loops of the immunoglobulin and determining the binding of the immunoglobulin to an epitope of an antigen, where the unmodified immunoglobulin does not significantly bind to said epitope, comprising the steps of providing a nucleic acid encoding an immunoglobulin having at least two structural loops, modifying at least one nucleotide residue of each of the structural loops, transferring the modified nucleic acid in an expression system, expressing the modified immunoglobulin, contacting the expressed modified immunoglobulin with an epitope, and determining whether the modified immunoglobulin binds to the epitope.
摘要翻译： 一种用于在免疫球蛋白的至少两个结构环中设计具有可变结构域和至少一个修饰的免疫球蛋白的方法，并确定免疫球蛋白与抗原表位的结合，其中未修饰的免疫球蛋白不显着结合所述表位， 包括以下步骤：提供编码具有至少两个结构环的免疫球蛋白的核酸，修饰每个结构环的至少一个核苷酸残基，在表达系统中转移修饰的核酸，表达经修饰的免疫球蛋白， 免疫球蛋白，并确定修饰的免疫球蛋白是否结合表位。
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公开(公告)号：US08323650B2
公开(公告)日：2012-12-04
申请号：US12786378
申请日：2010-05-24
申请人： Manfred Schuster , Gottfried Himmler , Guenter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Guenter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： A61K39/395
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译： 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段，其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。
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公开(公告)号：US20110020331A1
公开(公告)日：2011-01-27
申请号：US12786378
申请日：2010-05-24
申请人： Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
发明人： Manfred Schuster , Gottfried Himmler , Günter Waxenecker , Geert C. Mudde , Manuela Loidl , Gerda Redl , Hans Loibner
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10% reduced CDC activity.
摘要翻译： 本发明涉及衍生自亲本单克隆抗体的识别Lewis Y抗原的单克隆抗体或其衍生物或其片段，其特征在于与所述抗体或其衍生物或片段的Fc区相当的Fc区或区携带 双重杂交型N-糖基化模式，并且所述抗体显示出至少10倍的ADCC增加和至少10％的CDC活性降低。
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