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19 条记录 (耗时 0.02 秒)

    Repair of dna mutagenic damage
    1.
    发明申请
    Repair of dna mutagenic damage 审中-公开
    修复dna致突变性损伤

    公开(公告)号：US20060153781A1

    公开(公告)日：2006-07-13

    申请号：US10526830

    申请日：2003-09-05

    申请人： Graham Kelly ,  Alan Husband ,  Cath Walker

    发明人： Graham Kelly ,  Alan Husband ,  Cath Walker

    IPC分类号： A61K8/49

    CPC分类号： A61K8/498 ,  A61K31/12 ,  A61K31/35 ,  A61K31/40 ,  A61K31/475 ,  A61Q17/04

    摘要： Methods for protecting skin from UV-induced DNA mutagenic damage comprising administration of one or more of equol, dehydroequol, isoflav-3-ene and isoflavan compounds in admixture with a dermally acceptable carrier are described. Also described are methods for preventing skin cancer formation.

    摘要翻译： 描述了保护皮肤免受紫外线诱导的DNA诱变损伤的方法，其包括与皮肤可接受的载体混合施用一种或多种雌马酚，脱氢异丙醇，异黄酮-3-烯和异黄酮化合物。 还描述了防止皮肤癌形成的方法。

    Therapy of estrogen-associated disorders
    3.
    发明申请
    Therapy of estrogen-associated disorders 审中-公开
    雌激素相关疾病的治疗

    公开(公告)号：US20080038387A1

    公开(公告)日：2008-02-14

    申请号：US11785298

    申请日：2007-04-17

    申请人： Graham Kelly ,  Alan Husband

    发明人： Graham Kelly ,  Alan Husband

    IPC分类号： A61K36/48 ,  A61P5/30

    CPC分类号： A61K31/35 ,  A61K36/48 ,  A61K2300/00

    摘要： A method for the treatment, prophylaxis, amelioration or prevention of disorders associated with abnormally high activity of steroidal estrogens, which includes administering to a human subject a composition comprising an isoflavone-containing extract of clover or chick peas, said extract comprising primarily biochanin, or a ration of biochanin to one or more of the isoflavones from the group formononetin, daidzein and genistein in the range of from about 2:1 to about 5:1, optionally in association with one or more pharmaceutically acceptable carriers, excipients, auxiliaries and/or diluents is described. Also described are compositions and uses comprising the isoflavone containing extracts.

    摘要翻译： 一种用于治疗，预防，改善或预防与异常高活性的甾族雌激素相关的疾病的方法，其包括向人类受试者施用包含含有异黄酮的三叶草或鹰嘴豆提取物的组合物，所述提取物主要包含生长激素或 一种或多于一种或多种药学上可接受的载体，赋形剂，助剂和/或其药学上可接受的赋形剂，其中所述异黄酮与一种或多种药用载体，赋形剂，助剂和/ 或稀释剂。 还描述了包含含异黄酮的提取物的组合物和用途。

    Treatment of restenosis
    4.
    发明申请
    Treatment of restenosis 审中-公开
    再狭窄治疗

    公开(公告)号：US20050119301A1

    公开(公告)日：2005-06-02

    申请号：US10471668

    申请日：2002-03-15

    申请人： Alan Husband ,  Graham Kelly

    发明人： Alan Husband ,  Graham Kelly

    IPC分类号： A61K31/353 ,  A61K31/403 ,  A61K31/47

    CPC分类号： A61K31/47 ,  A61K31/353 ,  A61K31/403

    摘要： This invention relates to a method for inhibiting expression or activity of an adhesion molecule associated with an endothelial cell by contacting the adhesion molecule or endothelial cell with one or more isoflavone compounds or derivatives thereof. The invention also relates to a method of preventing or reducing the risk of restenosis after angioplasty, and to a method for the treatment or prophylaxis of atherosclerosis, coronary artery diseases, other cardiovascular diseases and inflammatory diseases mediated by adhesion molecules. The invention further relates to pharmaceutical compositions useful in these methods, and to methods for the manufacture of such medicaments.

    摘要翻译： 本发明涉及通过使粘附分子或内皮细胞与一种或多种异黄酮化合物或其衍生物接触来抑制与内皮细胞相关的粘附分子的表达或活性的方法。 本发明还涉及一种预防或降低血管成形术后再狭窄风险的方法，以及用于治疗或预防动脉粥样硬化，冠状动脉疾病，其他心血管疾病和由粘附分子介导的炎性疾病的方法。 本发明还涉及可用于这些方法的药物组合物和用于制备这些药物的方法。