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公开(公告)号：US09365598B2
公开(公告)日：2016-06-14
申请号：US14526901
申请日：2014-10-29
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Suk J. Hong , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Suk J. Hong , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
IPC分类号： C07K16/00 , C07K14/00 , C07F9/535 , C07F9/6561 , C07F9/6558 , C07K1/13 , G01N33/58
CPC分类号： C07F9/6561 , C07F9/535 , C07F9/65583 , C07K1/13 , C07K14/00 , C07K16/00 , C07K2317/20 , G01N33/582
摘要： A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions.
摘要翻译： 用乙二醇或（聚）乙二醇基改性的DyLight染料的膦衍生物。 在一个实施方案中，所述化合物可用于化学选择性连接反应。
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公开(公告)号：US20150119281A1
公开(公告)日：2015-04-30
申请号：US14526901
申请日：2014-10-29
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Suk J. Hong , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Suk J. Hong , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
IPC分类号： C07F9/6561 , G01N33/58 , C07K14/00 , C07K16/00 , C07K1/13
CPC分类号： C07F9/6561 , C07F9/535 , C07F9/65583 , C07K1/13 , C07K14/00 , C07K16/00 , C07K2317/20 , G01N33/582
摘要： A phosphine derivative of DyLight dyes modified with ethylene glycol or (poly)ethylene glycol groups. In one embodiment, the compounds are useful in chemoselective ligation reactions.
摘要翻译： 用乙二醇或（聚）乙二醇基改性的DyLight染料的膦衍生物。 在一个实施方案中，所述化合物可用于化学选择性连接反应。
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公开(公告)号：US20160168383A1
公开(公告)日：2016-06-16
申请号：US15042495
申请日：2016-02-12
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
CPC分类号： C09B23/06 , A61K49/0032 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B57/007 , C09B69/00 , C09B69/105 , G01N33/5306 , G01N33/533 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号：US20160176852A1
公开(公告)日：2016-06-23
申请号：US15042328
申请日：2016-02-12
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D401/14 , A61K49/14 , A61K49/12 , G01N33/58 , A61K49/04 , A61K49/16 , C07K16/40 , A61K47/48 , C07D209/18 , A61K49/22
CPC分类号： C07D401/14 , A61K47/6871 , A61K49/04 , A61K49/12 , A61K49/143 , A61K49/16 , A61K49/221 , C07D209/18 , C07D403/06 , C07D403/08 , C07K16/40 , C07K2317/76 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号：US20140255312A1
公开(公告)日：2014-09-11
申请号：US13787885
申请日：2013-03-07
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
CPC分类号： C09B23/06 , A61K49/0032 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B57/007 , C09B69/00 , C09B69/105 , G01N33/5306 , G01N33/533 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译： 用作具有与已知荧光化合物相当的特性的标签的化合物。 这些化合物可以与蛋白质和核酸结合，用于生物成像和分析。 提供了化合物的合成，共轭化合物的形成和用途，以及各自的具体非限制性实例。
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公开(公告)号：US20140072515A9
公开(公告)日：2014-03-13
申请号：US13780338
申请日：2013-02-28
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D209/18
CPC分类号： C07D401/14 , A61K47/6871 , A61K49/04 , A61K49/12 , A61K49/143 , A61K49/16 , A61K49/221 , C07D209/18 , C07D403/06 , C07D403/08 , C07K16/40 , C07K2317/76 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号：US09751868B2
公开(公告)日：2017-09-05
申请号：US13778678
申请日：2013-02-27
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： G01N33/533 , A61K49/00 , C07D403/14 , C07D209/60 , C07K19/00 , G01N33/58 , G01N33/543
CPC分类号： C07D403/14 , A61K49/0032 , A61K49/0058 , C07D209/60 , C07K19/00 , G01N33/533 , G01N33/54346 , G01N33/582
摘要： Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号：US20170158858A9
公开(公告)日：2017-06-08
申请号：US15042495
申请日：2016-02-12
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann
CPC分类号： C09B23/06 , A61K49/0032 , C09B23/0008 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/083 , C09B23/086 , C09B57/007 , C09B69/00 , C09B69/105 , G01N33/5306 , G01N33/533 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号：US20170114038A9
公开(公告)日：2017-04-27
申请号：US15042328
申请日：2016-02-12
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D401/14 , A61K49/14 , A61K49/12 , G01N33/58 , A61K49/04 , A61K49/16 , C07K16/40 , A61K47/48 , C07D209/18 , A61K49/22
CPC分类号： C07D401/14 , A61K47/6871 , A61K49/04 , A61K49/12 , A61K49/143 , A61K49/16 , A61K49/221 , C07D209/18 , C07D403/06 , C07D403/08 , C07K16/40 , C07K2317/76 , C09B23/06 , C09B23/083 , C09B23/086 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
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公开(公告)号：US20130230466A1
公开(公告)日：2013-09-05
申请号：US13780338
申请日：2013-02-28
申请人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
发明人： Greg Hermanson , Peter T. Czerney , Surbhi Desai , Matthias S. Wenzel , Boguslawa R. Dworecki , Frank G. Lehmann , Marie Christine Nlend
IPC分类号： C07D209/18
CPC分类号： C07D401/14 , A61K47/6871 , A61K49/04 , A61K49/12 , A61K49/143 , A61K49/16 , A61K49/221 , C07D209/18 , C07D403/06 , C07D403/08 , C07K16/40 , C07K2317/76 , C09B23/0016 , C09B23/0025 , C09B23/0066 , C09B23/06 , C09B23/083 , C09B23/086 , C09B69/00 , C09B69/10 , G01N33/582
摘要： Compounds used as labels with properties comparable to known fluorescent compounds. The compounds can be conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
摘要翻译： 用作具有与已知荧光化合物相当的特性的标签的化合物。 这些化合物可以与蛋白质和核酸结合，用于生物成像和分析。 提供了化合物的合成，共轭化合物的形成和用途，以及各自的具体非限制性实例。
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