-
公开(公告)号：US20070048774A1
公开(公告)日：2007-03-01
申请号：US11498974
申请日：2006-08-03
申请人： Gregory Coia , Peter Hudson , Peter Iliades , Robert Irving
发明人： Gregory Coia , Peter Hudson , Peter Iliades , Robert Irving
CPC分类号： C12N9/127 , C07K16/082 , C07K16/18 , C07K2317/622 , C12N15/102 , C12N15/1041 , C12N15/1058
摘要： Provided is a method for the mutation, synthesis and selection of a protein of interest, by first incubating a replicable RNA molecule encoding the protein with ribonucleoside triphosphate precursors of RNA and an RNA-directed RNA polymerase, such that the RNA-directed RNA polymerase replicates the RNA molecule but introduces mutations thereby generating a population of mutant RNA molecules. The mutant RNA molecules are then incubated with a translation system under conditions which result in the synthesis of a population of mutant proteins. After translation, the mutant proteins are linked to their encoding RNA molecules, and one or more mutant proteins of interest are selected.
摘要翻译： 提供了通过首先将编码蛋白质的可复制RNA分子与RNA的核糖核苷三磷酸前体和RNA指导的RNA聚合酶一起孵育来进行突变，合成和选择目的蛋白质的方法，使得RNA指导的RNA聚合酶复制 RNA分子引入突变，从而产生突变型RNA分子群体。 然后将突变体RNA分子与翻译系统在导致合成突变蛋白质群体的条件下孵育。 翻译后，突变蛋白与其编码RNA分子连接，并且选择一种或多种感兴趣的突变蛋白。
-
公开(公告)号：US20070065431A1
公开(公告)日：2007-03-22
申请号：US11588966
申请日：2006-10-27
申请人： Gregory Coia , Maria Galanis , Peter Hudson , Robert Irving , Stewart Nuttall
发明人： Gregory Coia , Maria Galanis , Peter Hudson , Robert Irving , Stewart Nuttall
CPC分类号： C07K14/70521 , A61K38/00 , C07K16/3061 , C07K16/40 , C07K2317/21 , C07K2317/22 , C07K2319/00 , Y10S530/808 , Y10S530/81 , Y10S530/812
摘要： The present invention relates to binding moieties comprising at least one monomeric V-like domain (VLD) derived from a non-antibody ligand, the at least one monomeric V-like domain being characterised in that at least one CDR loop structure or part thereof is modified or replaced such that the solubility of the modified VLD is improved when compared with the unmodified VLD.
摘要翻译： 本发明涉及包含至少一种衍生自非抗体配体的单体V样结构域（VLD）的结合部分，所述至少一个单体V样结构域的特征在于至少一个CDR环结构或其部分是 修饰或替换，使得当与未修饰的VLD相比时，修饰的VLD的溶解度得到改善。
-
公开(公告)号：US20060099611A1
公开(公告)日：2006-05-11
申请号：US11156014
申请日：2005-06-17
申请人： Robert Irving , Peter Hudson , Huseyin Mustafa , Kim Wark , Matias Abregu
发明人： Robert Irving , Peter Hudson , Huseyin Mustafa , Kim Wark , Matias Abregu
CPC分类号： C40B40/02 , C12N15/102 , C12N15/1037
摘要： The present invention relates to the field of evolution of nucleic acids in vivo and provides methods and compositions for introducing diversity into gene products. The present invention allows generation of new sequences that have desirable properties by virtue of high frequency mutation events within a cell. The high frequency mutation of a polynucleotide sequence results in, the production of a large population of new sequence variants. Appropriate selection and/or screening permits identification and isolation of mutant forms of the polynucleotide sequence as well as products resulting from expression of the mutant sequences.
摘要翻译： 本发明涉及体内核酸进化领域，并提供了将多样性引入基因产物的方法和组合物。 本发明允许通过细胞内的高频突变事件产生具有期望特性的新序列。 多核苷酸序列的高频突变导致大量新序列变体的产生。 适当的选择和/或筛选允许鉴定和分离突变形式的多核苷酸序列以及由突变序列的表达产生的产物。
-
公开(公告)号：US20090113332A1
公开(公告)日：2009-04-30
申请号：US11924592
申请日：2007-10-25
申请人： Touraj Farahmand , Peter Hudson , Edward J. Quilty
发明人： Touraj Farahmand , Peter Hudson , Edward J. Quilty
IPC分类号： G06F3/048
CPC分类号： G06F8/34
摘要： A computer-based graphical user interface for graphically controlling processing of hydrological data, comprising a display menu interface listing executable tools from the group comprising one or more of: hydrological data input, hydrological data validity checking and correction, and hydrological modeling, a GUI for selecting and arranging tools from the display menu in a graphical display area to construct a hydrological process, the selected tools each being represented by icons on the graphical display, and for establishing a connection between at least one output of a first tool and an input of a second tool said tools by graphically displaying the connection between said tools representative icon and input means for receiving user input to arrange and execute said constructed hydrological data processing process.
摘要翻译： 一种用于图形地控制水文数据处理的基于计算机的图形用户界面，包括显示菜单界面，列出来自包括水文数据输入，水文数据有效性检查和校正以及水文建模中的一个或多个的组的可执行工具，GUI 在图形显示区域中从显示菜单中选择和排列工具以构建水文过程，所选择的工具各自由图形显示器上的图标表示，并且用于建立第一工具的至少一个输出和第一工具的输入之间的连接 第二工具通过图形地显示所述工具代表图标之间的连接和输入装置，用于接收用户输入以布置和执行所述构造的水文数据处理过程。
-
公开(公告)号：US20080168339A1
公开(公告)日：2008-07-10
申请号：US11958129
申请日：2007-12-17
申请人： Peter Hudson , Touraj Farahmand , Edward J. Quilty
发明人： Peter Hudson , Touraj Farahmand , Edward J. Quilty
CPC分类号： G06F11/10
摘要： A method for identifying anomalies in time series data, the method comprising the steps of computing parity vectors for one or more data points in a predetermined sample of data points in the time series, the parity vector representing redundancy between an estimated true value and an error term for each of the said one or more data points, evaluating the parity vectors to determine a set of the parity vectors in a selected direction; and evaluating a statistical distribution of the set according to a predetermined criterion to determine a data point to be corrected whose parity vectors satisfy the criterion in the distribution.
摘要翻译： 一种用于识别时间序列数据中的异常的方法，所述方法包括以下步骤：在所述时间序列中的数据点的预定采样中计算一个或多个数据点的奇偶校验向量，所述奇偶校验向量表示估计的真值与误差之间的冗余 对所述一个或多个数据点中的每一个进行术语，评估所述奇偶校验向量以确定所选方向上的所述奇偶校验向量的集合; 以及根据预定标准评估所述集合的统计分布，以确定奇偶校验向量满足分布中的标准的待校正数据点。
-
公开(公告)号：US20070166310A1
公开(公告)日：2007-07-19
申请号：US11678127
申请日：2007-02-23
申请人： Peter Hudson , Craig Rosen , Wei He
发明人： Peter Hudson , Craig Rosen , Wei He
IPC分类号： A61K39/395 , A61K38/18 , C07K14/475 , C12Q1/68 , C07H21/04 , C12P21/06
CPC分类号： C07K16/22 , A61K38/00 , A61K39/00 , C07K14/475 , C07K14/575 , Y10S530/854
摘要： The present invention relates to human PGF polypeptides and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques, and antibodies and antagonist/inhibitors against such polypeptides. Also provided are methods of using such polypeptides therapeutically for treating prostate cancer, to promote tissue regeneration and to facilitate wound healing. Also provided is a diagnostic assay to detect prostate cancer and benign prostatic hyperplasia.
摘要翻译： 本发明涉及人PGF多肽和编码这种多肽的DNA（RNA）。 还提供了通过重组技术产生这种多肽的方法，以及针对这种多肽的抗体和拮抗剂/抑制剂。 还提供了使用这些多肽治疗性治疗前列腺癌，促进组织再生和促进伤口愈合的方法。 还提供了用于检测前列腺癌和良性前列腺增生的诊断测定法。
-
公开(公告)号：US20050016029A1
公开(公告)日：2005-01-27
申请号：US10626841
申请日：2003-07-25
申请人： Perry Auger , Peter Hudson , Erez Morag
发明人： Perry Auger , Peter Hudson , Erez Morag
CPC分类号： A43B13/26 , A43B1/0072 , A43B5/02 , A43B7/24 , A43B13/026 , A43B13/12 , A43B13/125 , A43B13/14
摘要： A soccer shoe includes an upper and a cleat assembly coupled to the upper. The cleat assembly further includes a medial support bar located on the medial side and a lateral support bar located on the lateral side. A portion of the cleat assembly located near a midfoot section of the medial support bar is stiffer than a portion of the cleat assembly located near a midfoot section of the lateral support bar. The medial support bar extends approximately from a region corresponding to the rear of the calcaneous of a properly fitted wearer to approximately the head of the first metatarsal of the wearer. The lateral support bar extends approximately from a region corresponding to the rear of the calcaneous of the wearer to approximately the head of the fifth metatarsal of the wearer. The cleat assembly is bonded to a cushioning midsole formed from heated and compressed ethylene vinyl acetate foam. The upper lacks a full-length lasting board and is bonded directly to the cushioning midsole. A lining covers a padded collar and extends inside a foot-receiving region of the shoe, with a portion of the foot-receiving region around a wearer's heel being substantially free of discontinuities.
摘要翻译： 足球鞋包括联接到鞋面的鞋面和防滑板组件。 防滑板组件还包括位于中间侧的中间支撑杆和位于外侧的侧向支撑杆。 位于内侧支撑杆的中脚部附近的防滑板组件的一部分比位于侧向支撑杆的中脚部附近的防滑板组件的部分更硬。 内侧支撑杆大致从对应于正确佩戴的佩戴者的皮肤后部的区域延伸到穿戴者的第一跖骨的头部。 侧支撑杆大致从对应于佩戴者的皮肤后方的区域延伸到大致佩戴者的第五跖骨的头部。 防滑板组件结合到由加热和压缩的乙烯 - 乙酸乙烯酯泡沫形成的缓冲中底。 上部缺少全长持久的板，并直接粘贴到缓冲中底。 衬里覆盖填充的衣领并且延伸在鞋的足部容纳区域内，脚部容纳区域的一部分围绕穿着者的脚后跟基本上没有间断。
-
公开(公告)号：US07869925B2
公开(公告)日：2011-01-11
申请号：US12500921
申请日：2009-07-10
申请人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
发明人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
CPC分类号： F16H59/08 , B60K37/06 , B60K2350/102 , F16H2059/081 , Y10T74/19251 , Y10T74/2003 , Y10T74/2014
摘要： A rotatable selector mechanism for a motor vehicle transmission has a selector knob rotatable in a housing to select an operating mode of the transmission among a number of selector positions indicated by a label (P, R, N, D, M). The selector mechanism further includes a detent plate which cooperates with a detent pin for maintaining the selector knob in each of positions. The detent plate is connected to position sensors for generating selector signals to a transmission control unit which supplies control signals to an actuator for operate the transmission according to the operating mode selected. The detent plate is also associated to the selector knob and to a drive correction means by means of clutch devices respectively to engage the detent plate to one of the selector knob and the drive correction means. The clutch devices and the drive corrections means are controlled by the transmission control unit to move the detent plate from a selector position selected by the driver to another selector position representative of the operating mode of the transmission by means of the drive correction means without moving the selector knob. The selector knob further includes an illuminated pointer constituted by one of several LEDs controlled by the transmission control unit so as to change the LED illuminated in front of the label according to the position of the detent plate when the latter has been moved by the drive correction means in order to indicate the operating mode of the transmission.
摘要翻译： 用于机动车辆变速器的可旋转选择器机构具有可在壳体中旋转的选择旋钮，以在由标签（P，R，N，D，M）指示的多个选择器位置之间选择变速器的操作模式。 选择器机构还包括与止动销配合的止动板，用于将选择旋钮保持在每个位置。 制动板连接到位置传感器，用于产生选择器信号到传动控制单元，该传动控制单元根据所选择的操作模式将控制信号提供给用于操作变速器的致动器。 制动板还通过离合器装置与选择器旋钮和驱动器校正装置相关联，以将制动板接合到选择器旋钮和驱动校正装置中的一个上。 离合器装置和驱动校正装置由变速器控制单元控制，以通过驱动校正装置将制动板从驾驶员选择的选择器位置移动到代表变速器的操作模式的另一选择器位置，而不移动 选择旋钮 所述选择器旋钮还包括由所述变速器控制单元控制的多个LED之一构成的照明指示器，以便根据所述制动板的位置，当所述LED驱动器被驱动校正移动时，根据所述制动板的位置改变在所述标签前面照亮的LED 意味着为了指示传输的操作模式。
-
公开(公告)号：US07571662B2
公开(公告)日：2009-08-11
申请号：US11205486
申请日：2005-08-17
申请人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
发明人： Carl Pickering , Alister Whelan , Mike Richardson , Rob Jerger , Peter Hudson
IPC分类号： F16H59/04
CPC分类号： F16H59/08 , B60K37/06 , B60K2350/102 , F16H2059/081 , Y10T74/19251 , Y10T74/2003 , Y10T74/2014
摘要： A rotatable selector mechanism for a motor vehicle transmission has a selector knob rotatable in a housing to select an operating mode of the transmission among a number of selector positions indicated by a label (P,R,N,D,M). The selector mechanism further includes a detent plate which cooperates with a detent pin for maintaining the selector knob in each of positions. The detent plate is connected to position sensors for generating selector signals to a transmission control unit which supplies control signals to an actuator for operate the transmission according to the operating mode selected. The detent plate is also associated to the selector knob and to a drive correction means by means of clutch devices respectively to engage the detent plate to one of the selector knob and the drive correction means. The clutch devices and the drive corrections means are controlled by the transmission control unit to move the detent plate from a selector position selected by the driver to another selector position representative of the operating mode of the transmission by means of the drive correction means without moving the selector knob. The selector knob further includes an illuminated pointer constituted by one of several LEDs controlled by the transmission control unit so as to change the LED illuminated in front of the label according to the position of the detent plate when the latter has been moved by the drive correction means in order to indicate the operating mode of the transmission.
摘要翻译： 用于机动车辆变速器的可旋转选择器机构具有可在壳体中旋转的选择旋钮，以在由标签（P，R，N，D，M）指示的多个选择器位置之间选择变速器的操作模式。 选择器机构还包括与止动销配合的止动板，用于将选择旋钮保持在每个位置。 制动板连接到位置传感器，用于产生选择器信号到传动控制单元，该传动控制单元根据所选择的操作模式将控制信号提供给用于操作变速器的致动器。 制动板还通过离合器装置与选择器旋钮和驱动器校正装置相关联，以将制动板接合到选择器旋钮和驱动校正装置中的一个上。 离合器装置和驱动校正装置由变速器控制单元控制，以通过驱动校正装置将制动板从驾驶员选择的选择器位置移动到代表变速器的操作模式的另一选择器位置，而不移动 选择旋钮 所述选择器旋钮还包括由所述变速器控制单元控制的多个LED之一构成的照明指示器，以便根据所述制动板的位置，当所述LED驱动器被驱动校正移动时，根据所述制动板的位置改变在所述标签前面照亮的LED 意味着为了指示传输的操作模式。
-
公开(公告)号：US20080275026A1
公开(公告)日：2008-11-06
申请号：US12213576
申请日：2008-06-20
申请人： Peter Hudson , Andrzej Roman Batt , Celine Marguerite Simone Heeney , Andrew John Baxter , Michael Bryan Roe , Peter Andrew Robson
发明人： Peter Hudson , Andrzej Roman Batt , Celine Marguerite Simone Heeney , Andrew John Baxter , Michael Bryan Roe , Peter Andrew Robson
IPC分类号： A61K31/5513 , A61K31/55 , C07D487/14 , A61P15/00 , C07D223/14 , A61K31/5517
CPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D495/04
摘要： Novel compounds according to general formula 1, wherein G1 is NR5R6 or a fused polycyclic group that are specific OT receptor agonists and/or V1a receptor antagonists. Pharmaceutical compositions comprising such compounds are useful in the treatment of, inter alia, primary dysmenorrhoea.
-
-
-
-
-
-
-
-
-
搜索结果
38 条记录 (耗时 0.022 秒)
