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    CUVETTE-BASED APPARATUS FOR BLOOD COAGULATION MEASUREMENT AND TESTING
    2.
    发明申请
    CUVETTE-BASED APPARATUS FOR BLOOD COAGULATION MEASUREMENT AND TESTING 审中-公开
    基于CUVETTE的设备用于血液凝固测量和测试

    公开(公告)号：US20100028207A1

    公开(公告)日：2010-02-04

    申请号：US12503665

    申请日：2009-07-15

    申请人： Gregory M. Colella ,  Henry D. Huang ,  Anthony F. Kuklo, JR. ,  Dimitri V. Shishkin ,  Maria Figueroa ,  James A. Mawhirt

    发明人： Gregory M. Colella ,  Henry D. Huang ,  Anthony F. Kuklo, JR. ,  Dimitri V. Shishkin ,  Maria Figueroa ,  James A. Mawhirt

    IPC分类号： G01N33/49 ,  B01L3/00

    CPC分类号： G01N33/4905 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2200/146 ,  B01L2200/16 ,  B01L2300/027 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/165 ,  B01L2400/0487 ,  B01L2400/086

    摘要： An apparatus for measuring blood clotting time includes a blood clot detection instrument and a cuvette for use with the blood clot detection instrument. The cuvette includes a blood sample receptor-inlet; a channel arrangement including at least one test channel for performing a blood clotting time measurement, a sampling channel having at least one surface portion that is hydrophilic, communicating with the blood sample receptor-inlet and the at least one test channel, and a waste channel having at least one surface portion that is hydrophilic, communicating with the sampling channel; and a vent opening communicating with the sampling channel. The sampling channel, the vent opening and the waste channel, coact to automatically draw a requisite volume of a blood sample deposited at the blood receptor-inlet, into the sampling channel. More specifically, air compressed within the blood clot detection instrument, the at least one test channel of the cuvette, and the section of the sampling channel extending beyond the vent opening of the cuvette, coacts with the waste channel to cause a leading edge of the blood sample drawn into the sampling channel from the blood receptor-inlet, to pull back within the sampling channel and uncover an optical sensor in of the blood clot detection instrument. The uncovering of the optical sensor activates a pump module of the blood clot detection instrument, which draws the requisite volume of the blood sample into the at least one test channel.

    摘要翻译： 用于测量血液凝固时间的装置包括血块检测仪器和与血块检测仪器一起使用的试管。 比色皿包括血液样本受体 - 入口; 包括用于进行血液凝固时间测量的至少一个测试通道的通道布置，具有至少一个亲水性表面部分，与血液样本受体入口和至少一个测试通道连通的采样通道，以及废物通道 具有至少一个亲水的表面部分，与采样通道连通; 以及与采样通道连通的通风口。 采样通道，通气口和废气通道共同作用，将沉积在血液受体入口处的血液样本的必需体积自动绘制到采样通道中。 更具体地，在血块检测仪器内压缩的空气，比色皿的至少一个测试通道以及延伸超过比色杯通气口的采样通道的部分与废物通道共同作用， 血液样本从血液受体入口吸入采样通道，在采样通道内拉回，并露出血块检测仪器中的光学传感器。 光学传感器的露出激活血块检测仪器的泵模块，其将血样的必要体积吸入至少一个测试通道。

    Production of emulsions of pharmaceutical compositions
    3.
    发明申请
    Production of emulsions of pharmaceutical compositions 审中-公开
    制备药物组合物的乳液

    公开(公告)号：US20060257434A1

    公开(公告)日：2006-11-16

    申请号：US11407512

    申请日：2006-04-20

    申请人： Mark Mugerditchian ,  Maria Figueroa

    发明人： Mark Mugerditchian ,  Maria Figueroa

    IPC分类号： A61K9/00

    CPC分类号： A61K31/522 ,  A61K9/0019 ,  A61K9/1075

    摘要： Disclosed are methods of producing an emulsion comprising determining a desired final pH of the emulsion, mixing an oil, surfactant, stabilizer, and a water-insoluble pharmaceutical, adjusting the pH of the mixture, and homogenizing the mixture, such that the starting pH of the mixture, the rotation speed of the homogenizer, and the temperature at which the homogenization is carried out are adjusted to give the desired pH.

    摘要翻译： 公开了生产乳液的方法，其包括确定乳液的所需最终pH，混合油，表面活性剂，稳定剂和水不溶性药物，调节混合物的pH并均化混合物，使得起始pH 混合物，均化器的旋转速度和进行均化的温度进行调节，得到所需的pH值。