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公开(公告)号：US20090136480A1
公开(公告)日：2009-05-28
申请号：US11882888
申请日：2007-08-06
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： A61K39/39 , A61K9/7061 , A61K2039/54 , A61K2039/55544
摘要： Transcutaneous immunostimulation administers at least one adjuvant by transcutaneous immunization to a subject who has undergone, is undergoing, or will undergo conventional vaccination or another immune response. A subject is selected for treatment to stimulate the immune response to a conventional vaccine or other immuno-therapy. A suspicion, medical history, or determination by a physician or veterinarian that the subject may fail to respond or only poorly respond to conventional vaccination or other immunotherapy because of age, acquired or congenital immunodeficiency, immunosuppression caused by disease or ablative therapy, or the use of reduced amounts of antigen in the conventional vaccine can be used to select subjects in need of treatment.
摘要翻译： 经皮免疫刺激通过经皮免疫给经历，正在接受或将要经历常规接种或其他免疫应答的受试者施用至少一种佐剂。 选择受试者用于治疗以刺激对常规疫苗或其它免疫疗法的免疫应答。 由于年龄，获得性或先天性免疫缺陷，由疾病或消融性治疗引起的免疫抑制，受试者可能无法应对或仅对常规接种疫苗或其他免疫治疗反应差或怀疑，病史或决心，或使用 可以使用常规疫苗中减少量的抗原来选择需要治疗的受试者。
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2.发明授权公开(公告)号：US09598472B2
公开(公告)日：2017-03-21
申请号：US14342565
申请日：2011-09-05
申请人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
CPC分类号： A61K39/08 , A61K2039/53 , A61K2039/55505 , A61K2039/55544 , A61K2039/575 , C07K14/33 , C07K16/1282 , C07K2317/76 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
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3.发明申请ISOLATED POLYPEPTIDE OF THE TOXIN A AND TOXIN B PROTEINS OF C. DIFFICILE AND USES THEREOF 有权毒素A的分离多肽和毒素B的毒素B蛋白及其用途公开(公告)号：US20150056238A1
公开(公告)日：2015-02-26
申请号：US14342565
申请日：2011-09-05
申请人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
发明人： Larry R. Ellingsworth , David Flyer , Jing-Hui Tian , Steven R. Fuhrmann , Stefanie Kluepfel-Stahl , Gregory M. Glenn , Kerstin Westritschnig
CPC分类号： A61K39/08 , A61K2039/53 , A61K2039/55505 , A61K2039/55544 , A61K2039/575 , C07K14/33 , C07K16/1282 , C07K2317/76 , C07K2319/00 , C07K2319/40 , C07K2319/55
摘要： This present invention provides C-TAB.G5 and C-TAB.G5.1 isolated polypeptides comprising the receptor binding domains of C. difficile toxin A and toxin B as set forth in the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 4. The C-TAB.G5 and C-TAB.G5.1 isolated polypeptides may be used to neutralize toxic effects of C. difficile toxin A and/or toxin B.
摘要翻译： 本发明提供了包含艰巨梭菌毒素A和毒素B的受体结合结构域的C-TAB.G5和C-TAB.G5.1分离的多肽，如SEQ ID NO：2和SEQ ID NO：2的氨基酸序列所示 NO：4.C-TAB.G5和C-TAB.G5.1分离的多肽可用于中和艰难梭菌毒素A和/或毒素B的毒性作用。
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公开(公告)号：US20090017056A1
公开(公告)日：2009-01-15
申请号：US11629620
申请日：2005-06-15
CPC分类号： A61K39/385 , A61K2039/6037 , A61K2039/627 , C07K2319/40 , C07K2319/55
摘要： This invention includes fusion proteins comprising a bacterial ADP-ribosylating exotoxin (bARE), or a variant or portion thereof, fused to a STa exotoxin, or a portion or variant thereof. Optionally, the exotoxins are fused via a peptide linker. The invention also includes compositions formulated for transcutaneous immunizations and/or induction of an immune response by epicutaneous administration comprising an effective amount of a fusion protein comprising a bacterial ADP-ribosylating exotoxin fused to a STa exotoxin. Optionally, the exotoxins are fused via a peptide linker.
摘要翻译： 本发明包括融合蛋白质，其包含与STa外毒素融合的细菌ADP-核糖基化外毒素（bARE）或其变体或部分，或其部分或变体。 任选地，外毒素通过肽接头融合。 本发明还包括配制用于经皮免疫和/或通过皮肤施用诱导免疫应答的组合物，其包含有效量的融合蛋白，所述融合蛋白包含与STa外毒素融合的细菌ADP-核糖基化外毒素。 任选地，外毒素通过肽接头融合。
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公开(公告)号：US08760282B2
公开(公告)日：2014-06-24
申请号：US13533659
申请日：2012-06-26
申请人： Gregory M. Glenn , Damon Silva , Timothy Henry
发明人： Gregory M. Glenn , Damon Silva , Timothy Henry
IPC分类号： G08B19/00
CPC分类号： G01F23/0061 , G08B21/182 , G08B25/10 , H04L67/12 , H04Q9/00 , H04Q2209/40 , H04W4/70 , H04W84/18
摘要： A server system for remote monitoring includes a wireless communication interface, a processor, and a storage device. The wireless communication interface receives at least one data packet over wireless communications from a remote monitoring system. The processor processes the data packet including sensor information from a sensor coupled to the remote monitoring system. The storage device stores the sensor information.
摘要翻译： 用于远程监视的服务器系统包括无线通信接口，处理器和存储设备。 无线通信接口通过无线通信从远程监视系统接收至少一个数据分组。 处理器处理来自耦合到远程监视系统的传感器的包括传感器信息的数据分组。 存储装置存储传感器信息。
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6.发明申请公开(公告)号：US20120171294A1
公开(公告)日：2012-07-05
申请号：US13421685
申请日：2012-03-15
CPC分类号： A01N25/16 , A01N25/12 , Y10T428/2982
摘要： The present invention relates to starch foam microparticles having a porous structure, and which typically have a diameter of less than or equal to about 50 microns. The present invention also relates to novel uses for the starch foam microparticles in beekeeping and in the pharmaceutical, plastics and fragrance industries.
摘要翻译： 本发明涉及具有多孔结构并且通常具有小于或等于约50微米的直径的淀粉泡沫微粒。 本发明还涉及在养蜂和制药，塑料和香料工业中淀粉泡沫微粒的新用途。
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公开(公告)号：US20100257780A1
公开(公告)日：2010-10-14
申请号：US12558146
申请日：2009-09-11
摘要： The charcoal-foam heating material is formed by combining a charcoal mixture with an aqueous surfactant and water to create a semi-homogenous charcoal-foam slurry. The slurry is poured into shaping molds so that the slurry dries into the charcoal-foam heating material. In the preferred embodiment, a concrete surfactant is used during the mixing process and the charcoal-foam slurry is formed into briquettes and used as a cooking fuel.
摘要翻译： 木炭泡沫加热材料通过将木炭混合物与水性表面活性剂和水组合以形成半均匀的木炭泡沫浆料而形成。 将浆料倒入成型模具中，使浆料干燥成炭泡沫加热材料。 在优选的实施方案中，在混合过程中使用混凝土表面活性剂，并将木炭泡沫浆料形成为团块并用作烹调燃料。
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公开(公告)号：US20120280809A1
公开(公告)日：2012-11-08
申请号：US13533659
申请日：2012-06-26
申请人： Gregory M. Glenn , Damon Silva , Timothy Henry
发明人： Gregory M. Glenn , Damon Silva , Timothy Henry
IPC分类号： G08B1/08
CPC分类号： G01F23/0061 , G08B21/182 , G08B25/10 , H04L67/12 , H04Q9/00 , H04Q2209/40 , H04W4/70 , H04W84/18
摘要： A server system for remote monitoring includes a wireless communication interface, a processor, and a storage device. The wireless communication interface receives at least one data packet over wireless communications from a remote monitoring system. The processor processes the data packet including sensor information from a sensor coupled to the remote monitoring system. The storage device stores the sensor information.
摘要翻译： 用于远程监视的服务器系统包括无线通信接口，处理器和存储设备。 无线通信接口通过无线通信从远程监视系统接收至少一个数据分组。 处理器处理来自耦合到远程监视系统的传感器的包括传感器信息的数据分组。 存储装置存储传感器信息。
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公开(公告)号：US20120201845A1
公开(公告)日：2012-08-09
申请号：US13348970
申请日：2012-01-12
申请人： Gregory M. Glenn , Carl R. Alving
发明人： Gregory M. Glenn , Carl R. Alving
IPC分类号： A61K39/00 , A61K39/145 , A61K31/7088 , A61P33/00 , A61P31/04 , A61P31/10 , A61P31/16 , A61K39/07 , A61P37/04
CPC分类号： A61K39/08 , A61K39/008 , A61K39/015 , A61K39/0258 , A61K39/05 , A61K39/099 , A61K39/102 , A61K39/104 , A61K39/107 , A61K39/116 , A61K39/12 , A61K2039/5252 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55505 , A61K2039/55522 , A61K2039/55533 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/70 , C12N2740/16234 , C12N2760/16134 , C12N2760/16234 , C12N2760/20134 , Y02A50/472 , Y02A50/474
摘要： Transcutaneous immunization can deliver antigen to the immune system through the stratum corneum without physical or chemical penetration to the dermis layer of the skin. This delivery system induces an antigen-specific immune response without the use of a heterologous adjuvant. This system can induce antigen-specific immune effectors after epicutaneous application of a formulation containing one or more antigens Immune responses that provide prophylactic and/or therapeutic treatments are preferred. Antigenic activities in the formulation may be found in the same molecule, two or more different molecules dissociated from each other, or multiple molecules in a complex formed by covalent or non-covalent bonds. For antigens which are proteinaceous, they may be provided in the formulation as a polynucleotide for transcutaneous genetic immunization. Besides simple application of a dry or liquid formulation to the skin, patches and other medical devices may be used to deliver antigen for immunization.
摘要翻译： 经皮免疫可通过角质层将免疫系统的抗原递送到皮肤真皮层，而不会物理或化学渗透到真皮层。 该递送系统在不使用异源佐剂的情况下诱导抗原特异性免疫应答。 该系统可以在外皮施用含有一种或多种抗原的制剂后诱导抗原特异性免疫效应物优选提供预防和/或治疗性治疗的免疫应答。 制剂中的抗原活性可以在相同的分子中发现，两个或更多个不同的分子彼此解离，或者通过共价或非共价键形成的复合物中的多个分子。 对于蛋白质的抗原，它们可以作为经皮基因免疫的多核苷酸提供在制剂中。 除了干燥或液体制剂对皮肤的简单应用之外，还可以使用贴片和其它医疗装置来递送用于免疫的抗原。
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公开(公告)号：US20110134917A1
公开(公告)日：2011-06-09
申请号：US13019975
申请日：2011-02-02
申请人： Gregory M. Glenn , Damon Silva , Timothy Henry
发明人： Gregory M. Glenn , Damon Silva , Timothy Henry
IPC分类号： H04L12/56
CPC分类号： G01F23/0061 , G08B21/182 , G08B25/10 , H04L67/12 , H04Q9/00 , H04Q2209/40 , H04W4/70 , H04W84/18
摘要： A server system for remote monitoring includes a wireless communication interface, a processor, and a storage device. The wireless communication interface receives at least one data packet over wireless communications from a remote monitoring system. The processor processes the data packet including sensor information from a sensor coupled to the remote monitoring system. The storage device stores the sensor information.
摘要翻译： 用于远程监视的服务器系统包括无线通信接口，处理器和存储设备。 无线通信接口通过无线通信从远程监视系统接收至少一个数据分组。 处理器处理来自耦合到远程监视系统的传感器的包括传感器信息的数据分组。 存储装置存储传感器信息。
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