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25 条记录 (耗时 0.02 秒)

    Piperidine compounds
    8.
    发明授权
    Piperidine compounds 失效
    哌啶化合物

    公开(公告)号：US5652246A

    公开(公告)日：1997-07-29

    申请号：US546263

    申请日：1995-10-20

    申请人： Guillaume de Nanteuil ,  Georges Remond ,  Bernard Portevin ,  Jacqueline Bonnet ,  Emmanuel Canet ,  Graham Birrell

    发明人： Guillaume de Nanteuil ,  Georges Remond ,  Bernard Portevin ,  Jacqueline Bonnet ,  Emmanuel Canet ,  Graham Birrell

    IPC分类号： A61K31/4427 ,  A61K31/445 ,  A61P1/00 ,  A61P11/00 ,  A61P13/02 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D401/06 ,  C07D471/04 ,  C07D471/02 ,  A61K31/415 ,  A61K31/44 ,  C07D235/22

    CPC分类号： C07D401/06 ,  C07D471/04

    摘要： The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl, phenyl, naphthyl, pyridyl or thienyl group, each phenyl, naphthyl, pyridyl or thienyl optionally being substituted,R.sub.2 represents a hydrogen atom or a substituted or unsubstituted alkyl, substituted or unsubstituted phenyl, cycloalkyl, piperidino or substituted or unsubstituted amino group,X represents CO or SO.sub.2,R.sub.3 represents hydrogen or alkyl,R.sub.4 represents alkyl, substituted or unsubstituted phenyl or trihalomethyl, or else R.sub.3 and R.sub.4 form, together with the carbon atoms which carry them, cyclo(C.sub.3 -C.sub.7)alkenyl,A represents phenyl, naphthyl or pyridyl ring, each phenyl, naphthyl or pyridyl ring optionally being substituted,their isomers, the corresponding quaternary ammonium salts of the piperidine and their addition salts with a pharmaceutically acceptable acid, an medicinal products containing the same are useful as antagonists of NK.sub.1 receptors.

    摘要翻译： 本发明涉及式（I）化合物：其中：R 1表示烷基，苯基，萘基，吡啶基或噻吩基，每个苯基，萘基，吡啶基或噻吩基任选被取代，R 2表示氢 原子或取代或未取代的烷基，取代或未取代的苯基，环烷基，哌啶子基或取代或未取代的氨基，X表示CO或SO 2，R 3表示氢或烷基，R 4表示烷基，取代或未取代的苯基或三卤甲基， R 4与携带它们的碳原子一起形成环（C 3 -C 7）链烯基，A代表苯基，萘基或吡啶环，每个苯基，萘基或吡啶基任选被取代，它们的异构体是相应的季铵盐 哌啶及其与药学上可接受的酸的加成盐，含有它们的药物可用作NK1受体的拮抗剂。

    4-methyl-5-substituted-1,3-oxazoles having anti-inflammatory activity
    9.
    发明授权
    4-methyl-5-substituted-1,3-oxazoles having anti-inflammatory activity 失效
    具有抗炎活性的4-甲基-5-取代-1,3-恶唑

    公开(公告)号：US5468761A

    公开(公告)日：1995-11-21

    申请号：US164464

    申请日：1993-12-09

    申请人： Guillaume de Nanteuil ,  Michel Vincent ,  Christine Lila ,  Jacqueline Bonnet ,  Armel Fradin

    发明人： Guillaume de Nanteuil ,  Michel Vincent ,  Christine Lila ,  Jacqueline Bonnet ,  Armel Fradin

    IPC分类号： A61K31/42 ,  A61K31/421 ,  A61P29/00 ,  C07D263/32

    CPC分类号： C07D263/32 ,  A61K31/42

    摘要： Compound of formula (I): ##STR1## in which: R.sub.1 represents 1-adamantyl, dicyclopropylmethyl, substituted or unsubstituted (C.sub.3 -C.sub.6) cycloalkyl or substituted or unsubstituted bicyclo[2.2.2]oct-1-yl,R.sub.2 represents: ##STR2## in which: m represents 1, 2 or 3,X represents oxygen or sulfur or N--R,R.sub.3 or R.sub.4, which are identical or different, represent hydrogen, (C.sub.1 -C.sub.6) alkyl or trifluoromethyl, ##STR3## n represents 0, 1 or 2, R.sub.5 represents hydroxy, or (C.sub.1 -C.sub.6) alkoxy, and anti-inflammatory medicinal products containing the same.

    摘要翻译： 式（I）化合物：其中：R1表示1-金刚烷基，二环丙基甲基，取代或未取代的（C3-C6）环烷基或取代或未取代的双环[2.2.2]辛-1-基，R2 表示： 其中：m表示1,2或3，X表示氧或硫或NR，R3或R4相同或不同，表示氢，（C1-C6）烷基或三氟甲基， IMAGE> n表示0,1或2，R 5表示羟基或（C 1 -C 6）烷氧基，和含有它们的抗炎药物。