公开(公告)号：US09062087B2

公开(公告)日：2015-06-23

申请号：US13575258

申请日：2011-01-14

申请人： Guilong Zhao ,  Hua Shao ,  Weiren Xu ,  Wei Liu ,  Yuli Wang ,  Lida Tang ,  Chubing Tan ,  Bingni Liu ,  Shijun Zhang

发明人： Guilong Zhao ,  Hua Shao ,  Weiren Xu ,  Wei Liu ,  Yuli Wang ,  Lida Tang ,  Chubing Tan ,  Bingni Liu ,  Shijun Zhang

IPC分类号： C07H7/04 ,  C07H7/06 ,  A61K31/70 ,  A61K31/351 ,  C07D309/10 ,  C07D409/10

CPC分类号： C07H7/04 ,  A61K31/351 ,  A61K31/70 ,  C07D309/10 ,  C07D409/10 ,  C07H7/06

摘要： The present invention relates to a sodium glucose cotransporter 2 (SGLT2) inhibitor with a phenyl C-glucoside structure, its preparation method, a pharmaceutical composition containing the same, and its use in treating diabetes and preparing an anti-diabetes medicament. The invention provides a compound with the structure of general formula I and a pharmaceutically acceptable salt and prodrug ester thereof,wherein, the definitions of R5 and R6 are selected from the following:(1) R5=R6=Me; (2) R5=Me, R6=OMe; (3) R5=Me, R6=H; (4) R5=Me, R6=F; (5) R5=F, R6=H; and (6) R5=OMe, R6=H.

摘要翻译： 本发明涉及具有苯基C-葡萄糖苷结构的钠葡萄糖协同转运蛋白2（SGLT2）抑制剂及其制备方法，含有该葡糖苷结构的药物组合物及其在治疗糖尿病中的用途以及制备抗糖尿病药物。 本发明提供具有通式I结构的化合物及其药学上可接受的盐和前药酯，其中R5和R6的定义选自如下：（1）R5 = R6 = Me; （2）R5 = Me，R6 = OMe; （3）R5 = Me，R6 = H; （4）R5 = Me，R6 = F; （5）R5 = F，R6 = H; 和（6）R5 = OMe，R6 = H。

公开(公告)号：US20130023486A1

公开(公告)日：2013-01-24

申请号：US13575258

申请日：2011-01-14

申请人： Guilong Zhao ,  Hua Shao ,  Weiren Xu ,  Wei Liu ,  Yuli Wang ,  Lida Tang ,  Chubing Tan ,  Bingni Liu ,  Shijun Zhang

发明人： Guilong Zhao ,  Hua Shao ,  Weiren Xu ,  Wei Liu ,  Yuli Wang ,  Lida Tang ,  Chubing Tan ,  Bingni Liu ,  Shijun Zhang

IPC分类号： C07H15/207 ,  A61P3/10 ,  A61K31/7034 ,  A61K31/7042 ,  C07H15/26 ,  C07H1/00

CPC分类号： C07H7/04 ,  A61K31/351 ,  A61K31/70 ,  C07D309/10 ,  C07D409/10 ,  C07H7/06

摘要： The present invention relates to a sodium glucose cotransporter 2 (SGLT2) inhibitor with a phenyl C-glucoside structure, its preparation method, a pharmaceutical composition containing the same, and its use in treating diabetes and preparing an anti-diabetes medicament. The invention provides a compound with the structure of general formula I and a pharmaceutically acceptable salt and prodrug ester thereof,wherein, the definitions of R5 and R6 are selected from the following: (1) R5=R6=Me; (2) R5=Me, R6=OMe; (3) R5=Me, R6=H; (4) R5=Me, R6=F; (5) R5=F, R6=H; and (6) R5=OMe, R6=H.

摘要翻译： 本发明涉及具有苯基C-葡萄糖苷结构的钠葡萄糖共转运蛋白2（SGLT2）抑制剂及其制备方法，含有该葡糖苷结构的药物组合物及其在治疗糖尿病中的用途以及制备抗糖尿病药物。 本发明提供具有通式I结构的化合物及其药学上可接受的盐和前药酯，其中R5和R6的定义选自如下：（1）R5 = R6 = Me; （2）R5 = Me，R6 = OMe; （3）R5 = Me，R6 = H; （4）R5 = Me，R6 = F; （5）R5 = F，R6 = H; 和（6）R5 = OMe，R6 = H。

公开(公告)号：US20110281922A1

公开(公告)日：2011-11-17

申请号：US13162121

申请日：2011-06-16

申请人： Guilong ZHAO ,  Weiren Xu ,  Yuli Wang ,  Lida Tang ,  Yiliang Li ,  Meixiang Zou ,  Wei Liu ,  Hua Shao ,  Chubing Tan ,  Peng Liu

发明人： Guilong ZHAO ,  Weiren Xu ,  Yuli Wang ,  Lida Tang ,  Yiliang Li ,  Meixiang Zou ,  Wei Liu ,  Hua Shao ,  Chubing Tan ,  Peng Liu

IPC分类号： A61K31/426 ,  A61P3/10 ,  C07D277/38

CPC分类号： C07D277/46 ,  C07D277/58 ,  C07D417/12

摘要： The present invention relates to the field of drugs associated with treating diabetes. Particularly, the present invention relates to a dipeptidyl peptidase-IV inhibitor having the structure shown by formula (I), which contains amide thiazole structure and has an effect on treating diabetes, and a preparation method and a pharmaceutical composition containing it, as well as use thereof in manufacture of the drugs for treating the diabetes, wherein, R1 is methyl; R2 is phenyl; phenyl, 2-thienyl substituted in a mono-substituted, bi-substituted manner by fluorine and methyl.

摘要翻译： 本发明涉及与治疗糖尿病有关的药物领域。 特别地，本发明涉及具有式（I）所示结构的二肽基肽酶-IV抑制剂，其含有酰胺噻唑结构并具有治疗糖尿病的作用，以及含有它的制备方法和药物组合物，以及 其用于制备用于治疗糖尿病的药物，其中，R 1为甲基; R2是苯基; 苯基，2-取代的噻吩基，被氟和甲基取代，双取代。

公开(公告)号：US08481577B2

公开(公告)日：2013-07-09

申请号：US13162121

申请日：2011-06-16

申请人： Guilong Zhao ,  Weiren Xu ,  Yuli Wang ,  Lida Tang ,  Yiliang Li ,  Meixiang Zou ,  Wei Liu ,  Hua Shao ,  Chubing Tan ,  Peng Liu

发明人： Guilong Zhao ,  Weiren Xu ,  Yuli Wang ,  Lida Tang ,  Yiliang Li ,  Meixiang Zou ,  Wei Liu ,  Hua Shao ,  Chubing Tan ,  Peng Liu

IPC分类号： A61K31/427 ,  C07D277/46

CPC分类号： C07D277/46 ,  C07D277/58 ,  C07D417/12

摘要： The present invention relates to the field of drugs associated with treating diabetes. Particularly, the present invention relates to a dipeptidyl peptidase-IV inhibitor having the structure shown by formula (I), which contains amide thiazole structure and has an effect on treating diabetes, and a preparation method and a pharmaceutical composition containing it, as well as use thereof in manufacture of the drugs for treating the diabetes, wherein, R1 is methyl; R2 is phenyl; phenyl, 2-thienyl substituted in a mono-substituted, bi-substituted manner by fluorine and methyl.

摘要翻译： 本发明涉及与治疗糖尿病有关的药物领域。 特别地，本发明涉及具有式（I）所示结构的二肽基肽酶-IV抑制剂，其含有酰胺噻唑结构并具有治疗糖尿病的作用，以及含有它的制备方法和药物组合物，以及 其用于制备用于治疗糖尿病的药物，其中，R 1为甲基; R2是苯基; 苯基，2-取代的噻吩基，被氟和甲基取代，双取代。

公开(公告)号：US11866156B1

公开(公告)日：2024-01-09

申请号：US17531766

申请日：2021-11-21

申请人： Wei Liu

发明人： Wei Liu

IPC分类号： B64C23/06 ,  B64C21/10

CPC分类号： B64C23/065 ,  B64C21/10

摘要： This invention is an apparatus for vortex generation by combining the function of means for vortex generation with the functions of the leading-edge aerodynamic surface, the airfoil, and/or the trailing-edge aerodynamic surface.

公开(公告)号：US11686448B1

公开(公告)日：2023-06-27

申请号：US17699103

申请日：2022-03-19

申请人： Wei Liu

发明人： Wei Liu

IPC分类号： B60Q1/00 ,  F21S41/683 ,  F21S41/32 ,  F21S41/43 ,  F21S41/25 ,  F21W102/135

CPC分类号： F21S41/683 ,  F21S41/25 ,  F21S41/32 ,  F21S41/43 ,  F21W2102/135

摘要： This invention is a projector headlight that, while offering dual beam patterns, boasts a 100% utilization of the light emitted from a light source by one of the following methods: (1) employing a reflective cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern, (2) using reversible cutoff shield means to reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern with no moving part involved, (3) utilizing a selective light-filter cutoff means to selectively reflect the incoming light from said light source back to the reflector to enhance the illumination in low-beam pattern without making use of any moving part, (4) using a low-beam light-emitting subassembly and a high-beam light-emitting subassembly that are separated by partition means to achieve dual beam patterns with no moving part, or (5) adopting a low-beam light-emitting subassembly in low-beam pattern and a high-beam light-emitting subassembly in high-beam pattern without any moving part.

公开(公告)号：USD952959S1

公开(公告)日：2022-05-24

申请号：US29778103

申请日：2021-04-10

申请人： Wei Liu

设计人： Wei Liu

公开(公告)号：US09588205B2

公开(公告)日：2017-03-07

申请号：US13582800

申请日：2011-03-10

申请人： Stefanie Remmele ,  Wei Liu ,  Tobias Ratko Voigt ,  Christian Stehning

发明人： Stefanie Remmele ,  Wei Liu ,  Tobias Ratko Voigt ,  Christian Stehning

IPC分类号： G01R33/50 ,  G01R33/56 ,  G01R33/561

CPC分类号： G01R33/50 ,  G01R33/5601 ,  G01R33/5613 ,  G01R33/5616

摘要： The invention relates to a magnetic resonance imaging method for simultaneous and dynamic determination of a longitudinal relaxation time T1 and a transversal relaxation time T2 of the nuclear spin system of an object, in the context of DCE or DSE MRI. In this respect, the invention makes use of a steady-state gradient echo pulse sequence comprising an EPI readout module.

摘要翻译： 本发明涉及一种用于在DCE或DSE MRI的背景下同时和动态地确定物体的核自旋系统的纵向弛豫时间T1和横向弛豫时间T2的磁共振成像方法。 在这方面，本发明利用包括EPI读出模块的稳态梯度回波脉冲序列。

公开(公告)号：US09349561B2

公开(公告)日：2016-05-24

申请号：US13340701

申请日：2011-12-30

申请人： Jinshu Wang ,  Wei Liu ,  Fan Yang ,  Xiang Liu ,  Hongyi Li ,  Meiling Zhou ,  Tieyong Zuo

发明人： Jinshu Wang ,  Wei Liu ,  Fan Yang ,  Xiang Liu ,  Hongyi Li ,  Meiling Zhou ,  Tieyong Zuo

IPC分类号： H01J1/14 ,  H01J1/142 ,  H01J1/13 ,  H01J1/144 ,  H01J9/04 ,  H01J23/05

CPC分类号： H01J1/142 ,  H01J1/13 ,  H01J1/14 ,  H01J1/144 ,  H01J9/047 ,  H01J23/05

摘要： Impregnated rare earth metal-containing barium-aluminum-scandate cathodes with a rare earth oxide doped tungsten matrix and methods for the fabrication thereof are described. In one aspect, an impregnated rare earth metal-containing barium-aluminum-scandate cathode comprises: a rare earth oxide doped tungsten matrix, and an impregnated active substance. The active substance comprises scandium oxide (Sc2O3), a second rare earth oxide, and barium calcium aluminate, wherein the molar ratio of Ba:Ca:Al is about 4:1:1.

摘要翻译： 描述了具有稀土氧化物掺杂钨基体的含浸稀土金属的钡 - 铝 - 钪酸盐阴极及其制造方法。 一方面，含浸稀土金属的钡 - 铝 - 钪酸盐阴极包括：掺杂稀土氧化物的钨基体和浸渍的活性物质。 活性物质包含氧化钪（Sc 2 O 3），第二稀土氧化物和铝酸钡钙，其中Ba:Ca:Al的摩尔比为约4:1:1。

公开(公告)号：US09248430B2

公开(公告)日：2016-02-02

申请号：US13510216

申请日：2010-07-22

申请人： Fuling Huang ,  Puke Mi ,  Sihan Wang ,  Jinhua Qian ,  Qian Chen ,  Sheng Xu ,  Jianzhong Li ,  Gang Wang ,  Baojun Zhang ,  Min Liu ,  Guizhi Wang ,  Xuemei Han ,  Jiabo Qu ,  Panfeng Lu ,  Shukun Sun ,  Xiuhui Wang ,  Yuxin Gao ,  Deshun Zhang ,  Ling Jiang ,  Buwei Yu ,  Libo Wang ,  Yali Wang ,  Lingting Fan ,  Peng Wei ,  Wei Liu ,  Guiyue Guo

发明人： Fuling Huang ,  Puke Mi ,  Sihan Wang ,  Jinhua Qian ,  Qian Chen ,  Sheng Xu ,  Jianzhong Li ,  Gang Wang ,  Baojun Zhang ,  Min Liu ,  Guizhi Wang ,  Xuemei Han ,  Jiabo Qu ,  Panfeng Lu ,  Shukun Sun ,  Xiuhui Wang ,  Yuxin Gao ,  Deshun Zhang ,  Ling Jiang ,  Buwei Yu ,  Libo Wang ,  Yali Wang ,  Lingting Fan ,  Peng Wei ,  Wei Liu ,  Guiyue Guo

IPC分类号： C07C6/10 ,  B01J21/04 ,  B01J37/02 ,  C07C2/22

CPC分类号： B01J21/04 ,  B01J37/0205 ,  B01J37/0207 ,  C07C2/22 ,  C07C2521/04 ,  C07C2527/126 ,  C07C11/02

摘要： A method for synthesis of 1-decene oligomer is provided, wherein 1-decene is polymerized at 80-120° C., 0.8-1.4 MPa in the presence of aluminum trichloride catalyst supported on gamma-alumina and n-hexane solvent where the volume ratio of 1-decene to n-hexane is 3:8-4:1. The catalyst is treated as follows: impregnating gamma-alumina carrier in 0.5-2.0 M of hydrochloric acid, sulfuric acid, nitric acid or mixtures thereof, then vacuum drying at 80-100° C. and calcining at 400-800° C.; dissolving 5-10 g of anhydrous aluminum trichloride in 100 ml of tetrachloromethane, trichloromethane or dichloromethane solvent; adding the obtained solution into 10-20 g of activated alumina carrier and obtaining the catalyst after vacuum drying. The conversion of 1-decene is 50 wt % or more. The oligomer has a kinematic viscosity at 40° C. of 6.0-25 mm2/s and a viscosity index of 160-262.

摘要翻译： 提供1-癸烯低聚物的合成方法，其中1-癸烯在负载在γ-氧化铝和正己烷溶剂上的三氯化铝催化剂存在下，在80-120℃，0.8-1.4MPa下聚合，其中体积 1-癸烯与正己烷的比例为3：8-4：1。 催化剂的处理如下：将γ-氧化铝载体浸入0.5-2.0M盐酸，硫酸，硝酸或其混合物中，然后在80-100℃真空干燥并在400-800℃下煅烧。 将5-10g无水三氯化铝溶于100ml四氯甲烷，三氯甲烷或二氯甲烷溶剂中; 将得到的溶液加入10-20g活性氧化铝载体中，真空干燥后得到催化剂。 1-癸烯的转化率为50重量％以上。 低聚物在40℃下的运动粘度为6.0-25mm 2 / s，粘度指数为160-262。