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    Apparatus with weeping tip and method of use
    4.
    发明授权
    Apparatus with weeping tip and method of use 失效

    公开(公告)号：US06949087B2

    公开(公告)日：2005-09-27

    申请号：US10855026

    申请日：2004-05-26

    申请人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： C12N15/09 ,  A61K31/711 ,  A61K48/00 ,  A61M5/158 ,  A61M5/32 ,  A61M25/00 ,  A61M31/00 ,  A61P43/00

    CPC分类号： A61M5/3286 ,  A61M5/3291 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0073

    摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

    Apparatus with weeping tip and method of use
    5.
    发明授权
    Apparatus with weeping tip and method of use 有权
    具有啜饮尖端和使用方法的设备

    公开(公告)号：US07252654B2

    公开(公告)日：2007-08-07

    申请号：US11218700

    申请日：2005-09-02

    申请人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. VanTassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： A61M5/32 ,  A61M25/00

    CPC分类号： A61M5/3286 ,  A61M5/3291 ,  A61M25/0068 ,  A61M2025/0057 ,  A61M2025/0073

    摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

    摘要翻译： 本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。 针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向 这点，从而确保注射过程中注射剂的均匀渗漏。 该针适于附接到导管或注射器。 在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于 刺穿组织。 引导导管可用于将本发明装置引导到远程内部注射部位。 本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

    Implantable device for promoting repair of a body lumen
    6.
    发明授权
    Implantable device for promoting repair of a body lumen 失效
    用于促进体腔修复的植入式装置

    公开(公告)号：US07235096B1

    公开(公告)日：2007-06-26

    申请号：US09382275

    申请日：1999-08-25

    申请人： Robert A. Van Tassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    发明人： Robert A. Van Tassel ,  David R. Holmes, Jr. ,  Robert S. Schwartz

    IPC分类号： A61F2/06

    CPC分类号： A61F2/82 ,  A61B5/0031 ,  A61B5/028 ,  A61B5/6862 ,  A61B5/6876 ,  A61F2/0077 ,  A61F2/91 ,  A61L31/14

    摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.

    摘要翻译： 提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。 表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长 细胞以有组织的模式。 或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。 本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

    Multi-section stent
    9.
    发明授权
    Multi-section stent 有权
    多段支架

    公开(公告)号：US06258117B1

    公开(公告)日：2001-07-10

    申请号：US09292558

    申请日：1999-04-15

    申请人： Allen R. Camrud ,  Robert S. Schwartz ,  David R. Holmes, Jr. ,  Timothy D. Argo ,  David Berry

    发明人： Allen R. Camrud ,  Robert S. Schwartz ,  David R. Holmes, Jr. ,  Timothy D. Argo ,  David Berry

    IPC分类号： A61F206

    CPC分类号： A61F2/88 ,  A61F2/07 ,  A61F2/82 ,  A61F2/86 ,  A61F2/89 ,  A61F2/90 ,  A61F2002/826 ,  A61F2002/828 ,  A61F2210/0004 ,  A61F2250/0031 ,  A61F2250/0039 ,  A61F2250/0067 ,  A61F2250/0071 ,  A61F2250/0098

    摘要： A multi-section stent includes a connecting structure that allows the stent sections to move and flex relative to one another. For deployment and positioning, the connecting structure connects the multiple stent sections and holds the stent sections substantially stationary relative to one another. Following deployment, the connecting structure allows the multiple stent sections to move relative to one another. Movable stent sections enable flexure of the stent upon deployment within a body lumen. This flexing structure allows better conformance of the stent to the shape of the body lumen, and exerts less overall pressure against the lumen wall, reducing the potential for trauma. Upon deployment, the multiple stent sections may be completely detached from one another. Alternatively, the stent sections may remain partially connected in a manner that allows substantial independent movement. The connecting structure can be manufactured to separate upon deployment, for example, by breaking or degrading within the body lumen in which the stent is positioned.

    摘要翻译： 多部分支架包括允许支架部分相对于彼此移动和弯曲的连接结构。 为了部署和定位，连接结构连接多个支架部分并且将支架部分相对于彼此基本上保持固定。 在部署之后，连接结构允许多个支架部分相对于彼此移动。 可移动支架部分能够在展开在体腔内时使支架挠曲。 该弯曲结构允许支架更好地符合体腔的形状，并且对腔壁施加较小的整体压力，降低创伤的可能性。 在部署时，多个支架部分可以彼此完全分离。 或者，支架部分可以以允许基本独立运动的方式保持部分连接。 连接结构可以被制造成在展开时分离，例如通过在支架所在的体腔内破碎或降解。