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公开(公告)号：US09309306B2
公开(公告)日：2016-04-12
申请号：US13590904
申请日：2012-08-21
申请人： Olivier Freytag , Guy Georges , Ekkehard Moessner , Olaf Mundigl , Gérald Tuffin , Pablo Umana
发明人： Olivier Freytag , Guy Georges , Ekkehard Moessner , Olaf Mundigl , Gérald Tuffin , Pablo Umana
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3053 , C07K2317/24 , C07K2317/33 , C07K2317/41 , C07K2317/732 , C07K2317/92
摘要： The invention provides anti-MCSP antibodies and methods of using the same.
摘要翻译： 本发明提供抗MCSP抗体及其使用方法。
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公开(公告)号：US20130078251A1
公开(公告)日：2013-03-28
申请号：US13590904
申请日：2012-08-21
申请人： Olivier Freytag , Guy Georges , Ekkehard Moessner , Olaf Mundigl , Gérald Tuffin , Pablo Umana
发明人： Olivier Freytag , Guy Georges , Ekkehard Moessner , Olaf Mundigl , Gérald Tuffin , Pablo Umana
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/3053 , C07K2317/24 , C07K2317/33 , C07K2317/41 , C07K2317/732 , C07K2317/92
摘要： The invention provides anti-MCSP antibodies and methods of using the same.
摘要翻译： 本发明提供抗MCSP抗体及其使用方法。
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公开(公告)号：US20110052582A1
公开(公告)日：2011-03-03
申请号：US12868845
申请日：2010-08-26
申请人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
发明人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
IPC分类号： A61K39/395 , C07K16/18 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00
CPC分类号： C07K16/30 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CDCP1（抗CDCP1抗体）的人源化抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08394928B2
公开(公告)日：2013-03-12
申请号：US12868845
申请日：2010-08-26
申请人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
发明人： Johannes Auer , Birgit Bossenmaier , Guy Georges , Alexander Lifke , Ekkehard Moessner , Gerhard Niederfellner
IPC分类号： C12P21/08
CPC分类号： C07K16/30 , C07K16/2896 , C07K2317/24 , C07K2317/41 , C07K2317/56 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to humanized antibodies against human CDCP1 (anti-CDCP1 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对人CDCP1（抗CDCP1抗体）的人源化抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US08859737B2
公开(公告)日：2014-10-14
申请号：US12971300
申请日：2010-12-17
申请人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
发明人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies binding to human HER3 (anti-HER3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及与人HER3（抗HER3抗体）结合的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US09050375B2
公开(公告)日：2015-06-09
申请号：US13382505
申请日：2010-06-30
申请人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
发明人： Birgit Bramlage , Ulrich Brinkmann , Rebecca Croasdale , Simone Dill , Wilma Dormeyer , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann , Ludger Markus Ickenstein , Kerstin Jahn-Hofmann , Matthias John , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/46 , A61K49/00 , A61K49/16 , A61K47/48 , A61K31/704 , A61K39/395 , B82Y5/00 , C07K16/16 , C07K16/28 , C07K16/32 , C07K16/44 , C12N15/11 , C12N15/113 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： This invention relates to bispecific antibodies and antibody fragments against a target protein and a hapten, wherein the hapten is PEG or biotin, most preferably digoxigenin, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及针对靶蛋白和半抗原的双特异性抗体和抗体片段，其中半抗原为PEG或生物素，最优选为地高辛，其制备方法，用作治疗或诊断试剂的递送平台，含有所述 抗体及其用途。
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公开(公告)号：US20130195844A1
公开(公告)日：2013-08-01
申请号：US13186109
申请日：2011-07-19
申请人： Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
发明人： Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
IPC分类号： C07K16/24
CPC分类号： C07K16/244 , C07K2317/76 , Y10S530/809
摘要： An antibody binding to IL-17 characterized by binding to the same IL-17 epitope to which monoclonal antibody 3C1 binds, and being of human IgG1 isotype modified in the hinge region at amino acid position 216-240, preferably at amino acid position 220-240, between CH1 and CH2 and/or in the second inter-domain region at amino acid position 327-331 between CH2 and CH3 has advantageous properties for the treatment of inflammatory diseases.
摘要翻译： 结合IL-17的抗体，其特征在于与单克隆抗体3C1结合的相同的IL-17表位结合，并且在氨基酸位置216-240，优选氨基酸位置220-位于铰链区修饰的人IgG1同种型， 240，CH1和CH2之间和/或在CH2和CH3之间的氨基酸位置327-331的第二区域间区域具有治疗炎性疾病的有利性质。
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公开(公告)号：US20110171222A1
公开(公告)日：2011-07-14
申请号：US12971300
申请日：2010-12-17
申请人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
发明人： Birgit Bossenmaier , Nikolaos Dimoudis , Thomas Friess , Guy Georges , Irene Kolm , Hans-Willi Krell , Valeria Lifke , Ekkehard Moessner
IPC分类号： A61K39/395 , C07K16/32 , C07H21/00 , C12N15/63 , C12N5/10 , C12N1/00 , C12P21/02 , A61P35/00
CPC分类号： C07K16/32 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/41 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to antibodies binding to human HER3 (anti-HER3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及与人HER3（抗HER3抗体）结合的抗体，其制备方法，含有所述抗体的药物组合物及其用途。
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公开(公告)号：US20100080812A1
公开(公告)日：2010-04-01
申请号：US12586893
申请日：2009-09-29
申请人： Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
发明人： Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
IPC分类号： A61K39/395 , C07K16/00 , C07H21/00 , A61P11/06 , A61P19/02 , C12N15/63 , C12P21/00 , C12N5/00
CPC分类号： C07K16/244 , C07K2317/76 , Y10S530/809
摘要： An antibody binding to IL-17 characterized by binding to the same IL-17 epitope to which monoclonal antibody 3C1 binds, and being of human IgG1 isotype modified in the hinge region at amino acid position 216-240, preferably at amino acid position 220-240, between CH1 and CH2 and/or in the second inter-domain region at amino acid position 327-331 between CH2 and CH3 has advantageous properties for the treatment of inflammatory diseases.
摘要翻译： 结合IL-17的抗体，其特征在于与单克隆抗体3C1结合的相同的IL-17表位结合，并且在氨基酸位置216-240，优选氨基酸位置220-位于铰链区修饰的人IgG1同种型， 240，CH1和CH2之间和/或在CH2和CH3之间的氨基酸位置327-331的第二区域间区域具有治疗炎性疾病的有利性质。
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公开(公告)号：US08003099B2
公开(公告)日：2011-08-23
申请号：US12586893
申请日：2009-09-29
申请人： Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
发明人： Johannes Auer , Nikolaos Dimoudis , Guy Georges , Petra Hanke , Hendrik Knoetgen , Ekkehard Moessner , Claire Louise Langrish
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/244 , C07K2317/76 , Y10S530/809
摘要： An antibody binding to IL-17 characterized by binding to the same IL-17 epitope to which monoclonal antibody 3C1 binds, and being of human IgG1 isotype modified in the hinge region at amino acid position 216-240, preferably at amino acid position 220-240, between CH1 and CH2 and/or in the second inter-domain region at amino acid position 327-331 between CH2 and CH3 has advantageous properties for the treatment of inflammatory diseases.
摘要翻译： 结合IL-17的抗体，其特征在于与单克隆抗体3C1结合的相同的IL-17表位结合，并且在铰链区在氨基酸位置216-240，优选在氨基酸位置220-修饰的人IgG1同种型， 240，CH1和CH2之间和/或在CH2和CH3之间的氨基酸位置327-331的第二区域间区域具有治疗炎性疾病的有利性质。
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