公开(公告)号：US20170037006A1

公开(公告)日：2017-02-09

申请号：US15072608

申请日：2016-03-17

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Tine Bryan Stensbol ,  Silke Miller ,  Heidi Lopez De Diego

IPC: C07D211/20

CPC classification number: C07D211/20 ,  C07B2200/13 ,  C07C55/08 ,  C07C55/12 ,  C07C59/08 ,  C07C229/24

Abstract: Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine and salts thereof are provided, e.g., for the treatment of neuropathic pain.

Abstract translation: 提供4- [2-（4-甲基苯基硫基） - 苯基]哌啶及其盐的结晶形式，例如用于治疗神经性疼痛。

公开(公告)号：US12152029B2

公开(公告)日：2024-11-26

申请号：US18051654

申请日：2022-11-01

Applicant: H. Lundbeck A/S

Inventor： Thomas Vetter ,  Martin Juhl ,  Heidi Lopez De Diego ,  Cheryl A. Grice ,  John J. M. Wiener ,  Daniel J. Buzard ,  Amy Allan ,  Susana Del Rio Gancedo ,  Samuel George Andrew ,  Antonio Cincotti ,  Adam Ross Patterson ,  Richard James Edwards

IPC: C07D471/10

Abstract: Described herein are new crystalline forms of the MAGL inhibitor 1-(1-(2-(pyrrolidin-1-yl)-4-(trifluoromethyl)benzyl)-1,8-diazaspiro[4.5]decane-8-carbonyl)-1H-pyrazole-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.

公开(公告)号：US20240190909A1

公开(公告)日：2024-06-13

申请号：US18511231

申请日：2023-11-16

Applicant: H. Lundbeck A/S

Inventor： Klaus Gjervig Jensen ,  Lisbet Kværnø ,  Morten Jørgensen ,  Martin Juhl ,  Heidi Lopez De Diego ,  Karin Fredholt ,  Frans Dennis Therkelsen ,  Tobias Gylling Frihed ,  Mikkel Fog Jacobsen

IPC: C07H15/26

CPC classification number: C07H15/26 ,  C07B2200/13

Abstract: The present invention relates to new solid forms of the compound (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(((4aR,10aR)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid with the formula (Id) below.




The compound of formula (Id) is a prodrug of a catecholamine for use in treatment of neurodegenerative diseases and disorders such as Parkinson's Disease.

公开(公告)号：US09475748B2

公开(公告)日：2016-10-25

申请号：US14567003

申请日：2014-12-11

Applicant: H. LUNDBECK A/S

Inventor： Svend Treppendahl ,  Heidi Lopez De Diego

IPC: A61K31/495 ,  A61K9/08 ,  C07D241/04 ,  C07C59/08 ,  C07D295/096

CPC classification number: A61K31/495 ,  A61K9/08 ,  C07C59/08 ,  C07D295/096

Abstract: Liquid formulations of lactic acid addition salts of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine are provided.

Abstract translation: 提供1- [2-（2,4-二甲基苯基硫基） - 苯基]哌嗪的乳酸加成盐的液体制剂。

公开(公告)号：US20160083359A1

公开(公告)日：2016-03-24

申请号：US14948775

申请日：2015-11-23

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  André Faldt ,  Arne Mørk ,  Heidi Lopez De Diego ,  René Holm ,  Tine Bryan Stensbøl ,  Lone Munch Ringgard ,  Michael J. Mealy ,  Michael Harold Rock ,  Jørgen Brodersen ,  Morten Jørgensen ,  Nicholas Moore

IPC: C07D295/096

CPC classification number: A61K31/495 ,  A61K9/14 ,  A61P25/22 ,  C07D295/096 ,  Y10T428/2982

Abstract: 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

Abstract translation: 1- [2-（2,4-二甲基苯基硫烷基）苯基]哌嗪显示出对SERT，5-HT3和5-HT1A的有效活性，并且可以用于治疗认知障碍，特别是抑郁症患者。

公开(公告)号：US09938286B2

公开(公告)日：2018-04-10

申请号：US15619645

申请日：2017-06-12

Applicant: H. Lundbeck A/S

Inventor： Heidi Lopez De Diego

IPC: A61K31/485 ,  C07D489/08

CPC classification number: C07D489/08

Abstract: The present invention relates to new nalmefene salts which salts fall within at least one of the two following categories: non-hydrate forming salts and non-solvate forming salts. In particular, the invention relates to the hydrogen adipate salt, the hydrogen malonate salt, the lactate salt, the hydrogen fumarate salt, the hydrogen succinate salt, the benzene sulfonate salt, the hydrogen maleate salt and the salicylate salt of nalmefene. The present invention also relates to such salts for use in therapy.

公开(公告)号：US09725458B2

公开(公告)日：2017-08-08

申请号：US14903384

申请日：2014-07-10

Applicant: H. Lundbeck A/S

Inventor： Heidi Lopez De Diego

IPC: C07D489/08 ,  A61K31/485

CPC classification number: C07D489/08

Abstract: The present invention relates to new nalmefene salts which salts fall within at least one of the two following categories: non-hydrate forming salts and non-solvate forming salts. In particular, the invention relates to the hydrogen adipate salt, the hydrogen malonate salt, the lactate salt, the hydrogen fumarate salt, the hydrogen succinate salt, the benzene sulfonate salt, the hydrogen maleate salt and the salicylate salt of nalmefene. The present invention also relates to such salts for use in therapy.

公开(公告)号：US20160152625A1

公开(公告)日：2016-06-02

申请号：US14903384

申请日：2014-07-10

Applicant: H. LUNDBECK A/S

Inventor： Heidi Lopez De Diego

IPC: C07D489/08

CPC classification number: C07D489/08

Abstract: The present invention relates to new nalmefene salts which salts fall within at least one of the two following categories: non-hydrate forming salts and non-solvate forming salts. In particular, the invention relates to the hydrogen adipate salt, the hydrogen malonate salt, the lactate salt, the hydrogen fumarate salt, the hydrogen succinate salt, the benzene sulfonate salt, the hydrogen maleate salt and the salicylate salt of nalmefene. The present invention also relates to such salts for use in therapy.

Abstract translation: 本发明涉及新的纳美芬盐，其盐落入以下两个类别中的至少一个：非水合物形成盐和非溶剂化物形成盐。 特别地，本发明涉及氢化己二酸盐，丙二酸氢盐，乳酸盐，富马酸氢盐，琥珀酸氢盐，苯磺酸盐，马来酸氢盐和纳美芬的水杨酸盐。 本发明还涉及用于治疗的这种盐。

公开(公告)号：US20150073018A1

公开(公告)日：2015-03-12

申请号：US14542210

申请日：2014-11-14

Applicant: H. Lundbeck A/S

Inventor： Benny Bang-Andersen ,  Andre Faldt ,  Tine Bryan Stensbol ,  Silke Miller ,  Heidi Lopez De Diego

IPC: C07D211/20

CPC classification number: C07D211/20 ,  C07B2200/13 ,  C07C55/08 ,  C07C55/12 ,  C07C59/08 ,  C07C229/24

Abstract: Crystalline forms of 4-[2-(4-methylphenylsulfanyl)-phenyl]piperidine and salts thereof are provided, e.g., for the treatment of neuropathic pain.

Abstract translation: 提供4- [2-（4-甲基苯基硫基） - 苯基]哌啶及其盐的结晶形式，例如用于治疗神经性疼痛。

公开(公告)号：US10071963B2

公开(公告)日：2018-09-11

申请号：US15323426

申请日：2015-07-03

Applicant: H. Lundbeck A/S

Inventor： Kristine Birklund Andersen ,  Michael Harold Rock ,  Heidi Lopez De Diego ,  Frans Dennis Therkelsen

IPC: A61K31/4045 ,  C07D209/16 ,  C07D209/14 ,  A61K45/06

CPC classification number: C07D209/16 ,  A61K31/4045 ,  A61K45/06 ,  C07B2200/13 ,  C07D209/14

Abstract: The present invention relates to a novel polymorphic form of N-[2-(6-fluoro-1H-indol-3-yl)ethyl]-3-(2,2,3,3-tetrafluoropropoxy)benzylamine hydrochloride.