公开(公告)号：US20150010612A1

公开(公告)日：2015-01-08

申请号：US14375460

申请日：2013-01-23

申请人： HERAEUS MEDICAL GMBH ,  CARL FREUDENBERG KG

发明人： Sebastian Vogt ,  Ekaterini Copanaki ,  Dirk Grafahrend ,  Denis Reibel ,  Daniel Neumüller

IPC分类号： A61L26/00 ,  D01D10/00

CPC分类号： A61L26/0038 ,  A61L24/0015 ,  A61L24/0042 ,  A61L24/08 ,  A61L24/102 ,  A61L24/104 ,  A61L26/0004 ,  A61L26/0066 ,  A61L2300/404 ,  A61L2300/418 ,  A61L2400/04 ,  D01D10/00 ,  C08L1/04 ,  C08L1/286 ,  C08L5/02

摘要： The invention relates to a biodegradable fleece containing (i) at least one polymer for inducing primary haemostasis, (ii) at least one non-proteinogenic, low-molecular, water-soluble activator of secondary haemostasis, and (iii) at least one non-proteinogenic, low-molecular, water-soluble inhibitor of fibrinolysis. The invention also relates to a method for producing a biodegradable fleece, in which (i) a fluidised fiber raw material, and additives if applicable, is placed in a container, (ii) the container is made to rotate, (iii) the fluidised fiber raw material is dispensed from the container by means of centrifugal forces, whereby fibers or filaments are formed, and (iv) a biodegradable fleece is produced from the fibers or filaments. The invention also relates to the use of said biodegradable fleece as a local haemostatic agent.

摘要翻译： 本发明涉及一种可生物降解的羊毛，其包含（i）至少一种用于诱导原发性止血的聚合物，（ii）至少一种非蛋白质，低分子水溶性二次止血的激活剂，和（iii）至少一种非 - - 蛋白质，低分子，水溶性纤维蛋白溶解抑制剂。 本发明还涉及生物降解羊毛的制造方法，其中（i）流化纤维原料和添加剂（如适用）放置在容器中，（ii）使容器旋转，（iii）流化的 通过离心力从容器中分配纤维原料，由此形成纤维或长丝，并且（iv）从纤维或长丝产生可生物降解的羊毛。 本发明还涉及所述可生物降解羊毛作为局部止血剂的用途。

公开(公告)号：US20200289715A1

公开(公告)日：2020-09-17

申请号：US16758858

申请日：2018-10-26

申请人： Carl Freudenberg KG

发明人： Karl-Heinz Heffels ,  Denis Reibel ,  Dirk Grafahrend ,  Guenter Germann ,  Oliver Boegershausen

IPC分类号： A61L27/58 ,  A61L27/56 ,  A61L27/22 ,  A61L27/24 ,  A61L27/34 ,  A61L27/18 ,  A61L27/54 ,  A61L27/48

摘要： A biocompatible soft tissue implant for introduction into a human body includes at least one layer comprising an elastomeric material, and at least one textile fabric arranged on the at least one layer comprising the elastomeric material. The at least one textile fabric forms a surface of the biocompatible soft tissue implant. The at least one textile fabric includes bioresorbable fibers which are embedded at least partially in the at least one layer comprising the elastomeric material.

公开(公告)号：US10736985B2

公开(公告)日：2020-08-11

申请号：US15118167

申请日：2015-02-12

申请人： Aesculap AG ,  Carl Freudenberg KG

发明人： Erich Odermatt ,  Rainer Bargon ,  Dirk Grafahrend ,  Daniel Neumüller ,  Denis Reibel

IPC分类号： A61L15/22 ,  A61L15/64 ,  A61L15/42 ,  D01D5/18 ,  D04H1/70 ,  D04H1/4382 ,  D04H1/30 ,  D04H1/425 ,  D01D5/00 ,  A61L15/32 ,  A61L15/28 ,  A61L15/58

摘要： A medical device in the form of a nonwoven wound dressing includes rotospun fibers including at least one synthetic and bioabsorbable polymer and at least one hydrophilic and/or tissue-adhesive polymer, and a method of producing the medical device including using rotospinning to produce fibers from a fiber raw material including at least one synthetic and bioabsorbable polymer and at least one hydrophilic and/or tissue-adhesive polymer.

公开(公告)号：US09782511B2

公开(公告)日：2017-10-10

申请号：US14996483

申请日：2016-01-15

申请人： BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH ,  CARL FREUDENBERG KG

发明人： Frank Plöger ,  Denis Reibel ,  Dirk Grafahrend ,  Daniel Neumüller

IPC分类号： A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61L15/32 ,  A61L15/64 ,  A61F13/00 ,  A61L15/18 ,  A61L15/22 ,  A61L15/42 ,  A61L15/44 ,  A61L15/62 ,  D04H1/30 ,  D04H1/4266

CPC分类号： A61L15/32 ,  A61F13/00 ,  A61K38/1875 ,  A61L15/18 ,  A61L15/22 ,  A61L15/325 ,  A61L15/42 ,  A61L15/425 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/604 ,  D04H1/30 ,  D04H1/4266

摘要： The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. Furthermore, the invention provides wound dressings, pads or implants comprising the novel non-woven fabrics.

公开(公告)号：US20180008743A1

公开(公告)日：2018-01-11

申请号：US15696321

申请日：2017-09-06

申请人： BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH ,  CARL FREUDENBERG KG

发明人： Frank Plöger ,  Denis Reibel ,  Dirk Grafahrend ,  Daniel Neumüller

IPC分类号： A61L15/32 ,  A61F13/00 ,  D04H1/30 ,  A61K38/18 ,  A61L15/22 ,  A61L15/64 ,  A61L15/62 ,  A61L15/44 ,  A61L15/42 ,  D04H1/4266 ,  A61L15/18

CPC分类号： A61L15/32 ,  A61F13/00 ,  A61K38/1875 ,  A61L15/18 ,  A61L15/22 ,  A61L15/325 ,  A61L15/42 ,  A61L15/425 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/604 ,  D04H1/30 ,  D04H1/4266

摘要： The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. Furthermore, the invention provides wound dressings, pads or implants comprising the novel non-woven fabrics.

公开(公告)号：US20170165394A1

公开(公告)日：2017-06-15

申请号：US15118167

申请日：2015-02-12

申请人： Aesculap AG ,  Carl Freudenberg KG

发明人： Erich Odermatt ,  Rainer Bargon ,  Dirk Grafahrend ,  Daniel Neumüller ,  Denis Reibel

IPC分类号： A61L15/22 ,  A61L15/58 ,  D01D5/00 ,  A61L15/64

摘要： A medical device in the form of a nonwoven wound dressing includes rotospun fibers including at least one synthetic and bioabsorbable polymer and at least one hydrophilic and/or tissue-adhesive polymer, and a method of producing the medical device including using rotospinning to produce fibers from a fiber raw material including at least one synthetic and bioabsorbable polymer and at least one hydrophilic and/or tissue-adhesive polymer.

公开(公告)号：US20160199530A1

公开(公告)日：2016-07-14

申请号：US14996483

申请日：2016-01-15

申请人： BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA MBH ,  CARL FREUDENBERG KG

发明人： Frank Plöger ,  Denis Reibel ,  Dirk Grafahrend ,  Daniel Neumüller

IPC分类号： A61L15/32 ,  A61L15/64 ,  A61L15/44

CPC分类号： A61L15/32 ,  A61F13/00 ,  A61K38/1875 ,  A61L15/18 ,  A61L15/22 ,  A61L15/325 ,  A61L15/42 ,  A61L15/425 ,  A61L15/44 ,  A61L15/62 ,  A61L15/64 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2300/604 ,  D04H1/30 ,  D04H1/4266

摘要： The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. Furthermore, the invention provides wound dressings, pads or implants comprising the novel non-woven fabrics.

摘要翻译： 本发明涉及含有生长和分化因子蛋白质的新型无纺织物。 所述织物被特别设计用于加速哺乳动物组织的组织再生和伤口愈合过程。 此外，本发明提供了包含新型无纺布的伤口敷料，垫或植入物。

公开(公告)号：US20200289716A1

公开(公告)日：2020-09-17

申请号：US16758861

申请日：2018-10-26

申请人： CARL FREUDENBERG KG

发明人： Karl-Heinz Heffels ,  Denis Reibel ,  Dirk Grafahrend ,  Alexandra Kaul ,  Yosuke Kadomae ,  Guenter Germann

IPC分类号： A61L29/14 ,  A61F2/20 ,  A61L29/12 ,  A61L29/04 ,  A61L29/16 ,  A61L29/08 ,  A61L29/06

摘要： A biocompatible composite material for complete or partial insertion into a human body includes at least one layer comprising an elastomeric material, and at least one textile fabric arranged on the at least one layer comprising the elastomeric material. The at least one textile fabric forms a surface of the biocompatible composite material. The at least one textile fabric includes bioresorbable fibers that are embedded at least partially in the at least one layer comprising the elastomeric material.