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公开(公告)号:US12071657B2
公开(公告)日:2024-08-27
申请号:US16643054
申请日:2017-10-20
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Adam Higgins , Pavel Kornilovich , Alexander N. Govyadinov , Michael J. Day
IPC: B01L3/00 , B01L7/00 , B01L99/00 , C12Q1/6806 , C12Q1/686
CPC classification number: C12Q1/686 , B01L3/502746 , B01L7/525 , C12Q1/6806 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2400/0688 , B01L2400/0694
Abstract: A nucleic acid amplifier may include a sample preparation zone, a fluid ejector, an amplification zone and a capillary break between the amplification zone and the fluid ejector.
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公开(公告)号:US12251701B2
公开(公告)日:2025-03-18
申请号:US16768881
申请日:2018-10-03
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Hilary Ely , Michael W. Cumbie , Adam Higgins , Rachel M. White , Erik D. Torniainen
Abstract: A fluid thermal processing device may include a substrate, a platform projecting from the substrate, a fluid heating element supported by the platform, a temperature sensing element, distinct from the fluid heating element, supported by the platform and an enclosure supported by and cooperating with the substrate to form a fluid chamber about the platform. The fluid chamber forms a volume of uniform thickness conforming to and about the platform.
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公开(公告)号:US11278894B2
公开(公告)日:2022-03-22
申请号:US16643693
申请日:2017-11-22
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Adam Higgins , Alexander Govyadinov
Abstract: The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a driver chip and a fluid chamber located over the driver chip. First and second microfluidic loops can have fluid driving ends and fluid outlet ends connected to the fluid chamber. The first and second microfluidic loops can include a portion thereof located outside a boundary of the driver chip. A first fluid actuator can be on the driver chip associated with the fluid driving end of the first microfluidic loop to circulate fluid through the first microfluidic loop. A second fluid actuator can be on the driver chip associated with the fluid driving end of the second microfluidic loop to circulate fluid through the second microfluidic loop.
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公开(公告)号:US20200291470A1
公开(公告)日:2020-09-17
申请号:US16645223
申请日:2017-10-13
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Adam Higgins , Viktor Shkolnikov , Jeffrey A. Nielsen
IPC: C12Q1/6874 , B01L3/02 , C12Q1/6806
Abstract: A method of sequencing multiple nucleic acid sequences, including: estimating a concentration of cells in a solution; and depositing a volume of the solution into a well on a well plate using an ejection device, the amount of solution selected to contain no more than a single cell.
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公开(公告)号:US11904312B2
公开(公告)日:2024-02-20
申请号:US16643264
申请日:2017-11-22
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Hilary Ely , Adam Higgins , Rachel M. White , Erik D. Torniainen , Tod Woodford , Michael W. Cumbie , Chien-Hua Chen
CPC classification number: B01L3/502715 , B01L3/50273 , B01L3/502723 , B01L2300/041 , B01L2300/048 , B01L2300/06 , B01L2300/0627 , B01L2300/0654 , B01L2300/0681 , B01L2300/0819 , B01L2300/12 , B01L2300/18 , B01L2400/0406 , B81B1/00
Abstract: The present disclosure is drawn to microfluidic devices. A microfluidic device can include a substrate, a lid mounted to the substrate, and a microchip mounted to the substrate. The lid mounted to the substrate can form a discrete microfluidic chamber between structures including an interior surface of the lid and a portion of the substrate. The lid can include an inlet and a vent positioned relative to one another to facilitate loading of fluid to the discrete microfluidic chamber via capillary action. A portion of the microchip can be positioned within the discrete microfluidic chamber.
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公开(公告)号:US20200284814A1
公开(公告)日:2020-09-10
申请号:US16645384
申请日:2017-10-13
Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.
Inventor: Viktor Shkolnikov , Adam Higgins , Jeffrey A. Nielsen
Abstract: A system for partitioning a liquid sample, the system including: an ejection device, the ejection device comprising an array of nozzles, wherein adjacent nozzles are separated by a constant distance in a first axis; and a microfluidics device including: a plurality of intake ports to receive a deposited droplet, wherein pairs of intake ports are separated by the same constant distance in the same first axis such that adjacent nozzles can simultaneously eject droplets to different intake ports.
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公开(公告)号:US20200041396A1
公开(公告)日:2020-02-06
申请号:US16476187
申请日:2017-02-10
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: George H. Corrigan , Adam Higgins , Chantelle Domingue
IPC: G01N11/06
Abstract: The viscosity of a fluid may be determined using a flow rate determination. The flow rate may be determined based on fluid presence determinations within a capillary channel. Also, a temperature of an environment surrounding a capillary channel may be determined and signals may be transmitted to a thermal element responsive to the determined temperature.
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公开(公告)号:US11366046B2
公开(公告)日:2022-06-21
申请号:US16476187
申请日:2017-02-10
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: George H. Corrigan , Adam Higgins , Chantelle Domingue
Abstract: The viscosity of a fluid may be determined using a flow rate determination. The flow rate may be determined based on fluid presence determinations within a capillary channel. Also, a temperature of an environment surrounding a capillary channel may be determined and signals may be transmitted to a thermal element responsive to the determined temperature.
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公开(公告)号:US11364498B2
公开(公告)日:2022-06-21
申请号:US16493402
申请日:2017-04-07
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Alexander Govyadinov , Adam Higgins , Pavel Kornilovich
Abstract: The present disclosure is drawn to microfluidic devices. In one example, a microfluidic device can include a first covered fluid feed slot in fluid communication with a first microfluidic channel and a second covered fluid feed slot in fluid communication with a second microfluidic channel. The first microfluidic channel can be formed adjacent to the second microfluidic channel but not in fluid communication with the second microfluidic channel. The first covered fluid feed slot can include a first fluid feed hole for filling a fluid into the first covered fluid feed slot. The second covered fluid feed slot can also include a second fluid feed hole for filling a fluid into the second covered fluid feed slot.
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公开(公告)号:US11235324B2
公开(公告)日:2022-02-01
申请号:US16643954
申请日:2017-11-22
Applicant: Hewlett-Packard Development Company, L.P.
Inventor: Adam Higgins , Alexander Govyadinov , Michael W. Cumbie
Abstract: The present disclosure is drawn to temperature-cycling microfluidic devices. In one example, a temperature-cycling microfluidic device can include a driver chip having a top surface and a heat exchange substrate having a top surface coplanar with the top surface of the driver chip. A fluid chamber can be located on the top surface of the driver chip. A first and second microfluidic loop can have fluid driving ends and fluid outlet ends connected to the fluid chamber and can include portions thereof located on the top surface of the heat exchange substrate. A first and second fluid actuator can be on the driver chip. The first and second fluid actuators can be associated with the fluid driving ends of the first and second microfluidic loops, respectively, to circulate fluid through the first and second microfluidic loops.
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