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公开(公告)号:US20160206569A1
公开(公告)日:2016-07-21
申请号:US14913455
申请日:2014-08-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Keiichiro TSURUSHIMA , Yasuhisa KOSE , Seiichiro TSURU , Shinji YAMASOTO , Takaaki YOSHINAGA
IPC: A61K9/70
CPC classification number: A61K9/7061 , A61L15/225 , A61L15/585 , A61L15/60 , C08F220/14 , C08L33/02 , C08L71/00 , C08L33/08 , C08F2220/1858
Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.
Abstract translation: 一种凝胶贴片,其包含支撑体上的膏药层,所述膏药层包含至少中和的聚丙烯酸,聚(丙烯酸甲酯/丙烯酸2-乙基己酯)乳液和水的混合物,其中所述聚(丙烯酸甲酯/ 丙烯酸乙基己酯)乳液是通过在介质沸点以上加热而蒸发残留物为57〜61%的乳液,其存在量为中和的聚丙烯酸的质量的至少2.5倍,优选至少3倍 酸。
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公开(公告)号:US20140371693A1
公开(公告)日:2014-12-18
申请号:US14326014
申请日:2014-07-08
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.,
Inventor: Kiyomi TSURUDA , Shinji YAMASOTO , Kouki SHOHO , Masaru NAKANISHI
IPC: A61L15/44 , A61L15/58 , A61K31/695 , A61L15/24
CPC classification number: A61L15/44 , A61F13/00 , A61F15/00 , A61K9/7053 , A61K9/7076 , A61K31/045 , A61K31/618 , A61K31/695 , A61L15/24 , A61L15/58 , A61L2300/216 , B32B7/12 , Y10T428/28 , Y10T428/2852 , Y10T442/2738 , Y10T442/3561
Abstract: An adhesive preparation comprising a stretchable support and an adhesive layer laminated on at least one side of the support, wherein the stretchable support comprises a interlock woven fabric subjected to crimping processing, the adhesive layer contains 10% by mass or more of methyl salicylate with respect to the total mass of the layer, the whole adhesive preparation has moisture permeability of 1 to 350 g/m2·24 hr measured at a temperature of 40° C. and a relative humidity of 90%, and the methyl salicylate has a plasma AUC0-24 ranging from 3.0 to 60.0 ng·hr/mL in terms of a mean±standard deviation, and salicylic acid as a metabolite of the methyl salicylate has a plasma AUC0-24 ranging from 5000 to 13000 ng·hr/mL in terms of a mean±standard deviation, when the adhesive preparation is applied to a human skin for 8 hours such that an application amount of the adhesive layer applied is 50 to 300 g/m2 and a contact area is 280 cm2.
Abstract translation: 一种粘合剂制剂,其包含层压在所述载体的至少一侧的可拉伸载体和粘合剂层,其中所述可拉伸载体包括进行压接加工的互锁织物,所述粘合剂层包含10质量%以上的水杨酸甲酯, 相对于该层的总质量,整个粘合剂在40℃,相对湿度90%的温度下测得的透湿度为1〜350g / m 2·24小时,水杨酸甲酯的血浆AUC 0 -24的范围为3.0〜60.0ng·hr / mL,以水杨酸甲酯为代表的水杨酸的血浆AUC 0-24为5000〜13000ng·hr / mL,以 当将粘合剂制剂施用于人类皮肤8小时,使得施加的粘合剂层的施用量为50至300g / m 2,接触面积为280cm 2时,其平均值为±标准偏差。
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公开(公告)号:US20250161229A1
公开(公告)日:2025-05-22
申请号:US18839843
申请日:2022-12-22
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Sho SATO , Keiichiro TSURUSHIMA , Shinji YAMASOTO , Tetsuro TATEISHI
Abstract: The present invention relates to a poultice including: a backing layer; and an adhesive agent layer, wherein the adhesive agent layer comprises at least one selected from the group consisting of carboxymethyl cellulose and pharmaceutically acceptable salts thereof; a silicic anhydride; a drug; and a water-soluble polymer; and a particle diameter D50 at which a cumulative volume in a particle size distribution of the silicic anhydride becomes 50% is 0.2 to 9.0 μm.
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公开(公告)号:US20240067441A1
公开(公告)日:2024-02-29
申请号:US18270760
申请日:2022-02-14
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Keiichiro TSURUSHIMA , Shinji YAMASOTO , Tetsuro TATEISHI
CPC classification number: B65D83/0805 , B65D75/5855 , B65D83/0894 , B65D85/62 , B65D2575/586
Abstract: A packaging bag according to one example includes: a bag body configured to store a plurality of folded patches; an opening formed in the bag body; and a flap label configured to cover the opening such that the opening is capable of being opened and closed. The opening is formed such that Lp/La is 1.5 to 2.5 and Lq/Lb is 1.8 to 2.8, where La denotes a first length of the opening along a first direction, Lp denotes a first length of the folded patch along the first direction, Lb denotes a second length of the opening along a second direction orthogonal to the first direction, the second length being shorter than the first length, and Lq denotes a second length of the folded patch along the second direction.
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公开(公告)号:US20160361281A1
公开(公告)日:2016-12-15
申请号:US15121534
申请日:2015-02-26
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Seiichiro TSURU , Masayoshi MAKI , Shinji YAMASOTO , Takaaki TERAHARA
IPC: A61K31/192 , D03D15/00 , A61K47/10 , A61K31/12 , A61K9/70
CPC classification number: A61K31/192 , A61K9/0014 , A61K9/7023 , A61K9/7069 , A61K31/12 , A61K47/10 , D03D15/00
Abstract: The invention provides a gel patch comprising a support and an adhesive layer on the support, wherein the adhesive layer comprises 1.5 to 2.5 mass % of ketoprofen, 1.5 to 2.5 mass % of 4-tert-butyl-4′-methoxydibenzoylmethane and 12 to 18 mass % of propylene glycol, based on the total mass of the adhesive layer.
Abstract translation: 本发明提供一种凝胶贴片,其包含载体和载体上的粘合剂层,其中粘合剂层包含1.5至2.5质量%的酮洛芬,1.5至2.5质量%的4-叔丁基-4'-甲氧基二苯甲酰甲烷和12至18 丙二醇的质量%,基于粘合剂层的总质量。
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