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Patent Agency Ranking
公开(公告)号：US11360112B2
公开(公告)日：2022-06-14
申请号：US16330423
申请日：2017-08-04
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Masashi Fukaya , Eiichiro Takada , Takuya Takahashi
IPC: G01N35/10
Abstract: A cleaning water flow velocity during nozzle cleaning is momentarily changed by using a pressure changing mechanism, for example, a syringe. That is, after the start of cleaning, a solenoid valve is opened, and an aspirating operation of the syringe is momentarily performed by a fixed amount in a state where a flow of cleaning water in a nozzle is developed, whereby a nozzle flow velocity is momentarily decelerated. Immediately thereafter, the syringe is pushed back to a home position again, and the flow velocity in the nozzle is accelerated again. A cleaning effect can be improved by performing transition of velocity distribution to various states. Flow velocity control by the pressure changing mechanism can be realized without inhibiting a dispensing cycle, and the cleaning effect of the nozzle can be improved without changing the pressure of a liquid feeding pump or extending the cleaning time.
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公开(公告)号：US10208277B2
公开(公告)日：2019-02-19
申请号：US15107548
申请日：2014-12-24
Applicant: Hitachi High-Technologies Corporation
Inventor： Akihiro Shimase , Kazumichi Imai , Eiichiro Takada , Sadamitsu Aso
Abstract: According to the present invention, a problem of closed systems, namely minimizing the number of electromagnetic valves required to control a plurality of flow paths, can be addressed, and thus a low-cost cell culture device can be achieved. In this flow-path control method for X number of flow paths satisfying X≤2N, the X number of flow paths are selected by using N number of valves to simultaneously and selectively control the opening and closing of the plurality of flow paths.
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公开(公告)号：US10266801B2
公开(公告)日：2019-04-23
申请号：US15106945
申请日：2014-12-24
Applicant: Hitachi High-Technologies Corporation
Inventor： Akihiro Shimase , Kazumichi Imai , Eiichiro Takada , Sadamitsu Aso
Abstract: According to the present invention, a simple structure can be used to achieve reliable liquid delivery with no residual air, and simple attachment/detachment of a culture vessel, and thus a closed-system cell culture device exhibiting high reliability can be constructed at low cost. In the present invention, a liquid is supplied or discharged while a culture vessel is in an inclined state. The culture vessel is provided with two flow paths, namely an intake flow path and a discharge flow path, which connect a culture chamber and a connection member. Points where the flow paths join with the culture chamber are respectively configured as an intake port and a discharge port. The discharge port is provided in the position nearest to the axis of inclination of the culture vessel. The intake port is provided in a plane projected from a vertical plane including the aforementioned axis of inclination.
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公开(公告)号：US11009515B2
公开(公告)日：2021-05-18
申请号：US16331583
申请日：2017-08-04
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Takuya Takahashi , Hitoshi Tokieda , Eiichiro Takada , Masashi Fukaya
Abstract: An automatic analyzer capable of controlling an interval between the tip of a sample nozzle and the bottom of a reaction container regardless of individual differences between reaction containers and sample nozzles and suppressing adhesion of a sample to the sample nozzle is disclosed. Sample nozzles 13a and 14a are moved toward the bottom surface of a reaction container 2, the movement of the sample nozzles is stopped at a point in time when a stop position detector 46 detects a stop position detection plate 45, the sample nozzles are ascended from the stop position to a position where the stop position detection plate 45 separates from a detection range of the stop position detector 46, and an arm 44 is moved upward by a moving distance stored in a memory.
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公开(公告)号：US10138456B2
公开(公告)日：2018-11-27
申请号：US15327208
申请日：2015-07-08
Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION
Inventor： Akihiro Shimase , Kazumichi Imai , Sadamitsu Aso , Eiichiro Takada , Masako Kawarai , Toshinari Sakurai
Abstract: A device which automatically performs a step in which expanded and cultured cells are diluted to a desired cell concentration and re-inoculated using a cell-concentration adjustment device having an inlet for taking in a cell suspension; an outlet for discharging a diluted cell suspension; and a flow path which is provided between the inlet and the outlet and is capable of holding a cell suspension, the flow path being provided with: a liquid delivery pump for causing a cell suspension inside to flow; a cell-concentration measurement instrument for collecting data related to a cell concentration per unit amount of the cell suspension; and a dilution-liquid container for holding a dilution liquid which is supplied to the flow path to dilute the cell suspension. The device further includes a control unit for controlling at least the liquid delivery pump on the basis of the data obtained by the cell-concentration measurement instrument, wherein the control unit determines, on the basis of the data obtained by the cell-concentration measurement instrument, an amount of the dilution liquid required to bring the cell concentration to the desired concentration, and drives the liquid delivery pump so as to take in the required amount of the dilution liquid into the flow path and mix the cell suspension and the dilution liquid.
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