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    BIOPOLYMER ANALYSIS DEVICE AND ANALYSIS SYSTEM
    3.
    发明申请
    BIOPOLYMER ANALYSIS DEVICE AND ANALYSIS SYSTEM 审中-公开

    公开(公告)号：US20180217123A1

    公开(公告)日：2018-08-02

    申请号：US15506090

    申请日：2015-07-06

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Yusuke GOTO ,  Takanobu HAGA

    IPC: G01N33/487 ,  G01N27/416 ,  C12Q1/6869

    CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/416 ,  C12Q2523/308 ,  C12Q2563/155 ,  C12Q2565/125 ,  C12Q2565/631

    Abstract: To slow down the speed of a biopolymer passing through a nanopore during electrophoresis to such a speed that enables a monomer sequence analysis to be performed. A biopolymer analysis device includes two tanks 101a and 101b each capable of storing a solution containing a biopolymer and an electrolyte, a pair of electrodes 105a and 105b, a thin film 104 with a nanopore, and a three-dimensional structure 103 disposed on the thin film. The three-dimensional structure has a void that can store a solution, and the void forms a flow channel, the flow channel being adapted to allow the solution to pass therethrough from the nanopore to a portion above the three-dimensional structure, and having on its surface a functional group capable of adsorbing the biopolymer. Thus, when a voltage is applied, the three-dimensional structure is not re-dispersed in the solution at least in the range of a hemisphere having the nanopore as the center and having a biopolymer trapping length r as the radius.

    DETECTOR FOR LIQUID CHROMATOGRAPHY
    4.
    发明申请
    DETECTOR FOR LIQUID CHROMATOGRAPHY 有权
    液相色谱检测仪

    公开(公告)号：US20150090014A1

    公开(公告)日：2015-04-02

    申请号：US14477989

    申请日：2014-09-05

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Yusuke GOTO ,  Masao KAMAHORI ,  Kiyotoshi MORI

    IPC: G01N30/74 ,  G01N30/86

    CPC classification number: G01N30/74 ,  G01N30/8641 ,  G01N21/33 ,  G01N21/35

    Abstract: A detector for liquid chromatography has light sources that generate light in an ultraviolet region and in a near-infrared region; a flow cell, through which sample liquid flows; an optical system to let light generated from the light sources become incident on the flow cell concurrently; a detection element that detects light in the ultraviolet region that passes through the flow cell; a detection element that detects light in the near-infrared region that passes through the flow cell; and an arithmetic operation part that performs arithmetic operation of a first signal value obtained from the detection element and of a second signal value obtained from the detection element. The arithmetic operation part combines the first signal value and the second signal value to calculate a signal value with a reduced baseline fluctuation resulting from a mobile phase during a gradient analysis.

    Abstract translation: 用于液相色谱的检测器具有在紫外区域和近红外区域产生光的光源; 流动池，样品液体通过该流动池流动; 使从光源产生的光同时入射到流动池的光学系统; 检测通过所述流通池的紫外线区域的光的检测元件; 检测通过所述流通池的近红外区域的光的检测元件; 以及算术运算部，其对从所述检测元件获得的第一信号值和从所述检测元件获得的第二信号值进行算术运算。 算术运算部分组合第一信号值和第二信号值，以在梯度分析期间计算由流动相产生的基线波动减小的信号值。

    Method and Apparatus for Analyzing Biomolecules
    5.
    发明申请
    Method and Apparatus for Analyzing Biomolecules 审中-公开

    公开(公告)号：US20190292589A1

    公开(公告)日：2019-09-26

    申请号：US16307636

    申请日：2016-06-10

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Michiru FUJIOKA ,  Yusuke GOTO ,  Takahide YOKOI

    IPC: C12Q1/6869 ,  G01N27/447 ,  G01N33/487

    Abstract: The purpose of the invention is to provide a method for analyzing biomolecules with which it is possible to easily suppress the occlusion of nanopores. The first embodiment of the invention is a method for analyzing biomolecules including a step for preparing a substrate having nanopores, a step for placing a sample solution including biomolecules and at least one compound selected from the group consisting of primary amines, secondary amines, guanidine compounds, and salts thereof on the substrate, and a step for detecting the changes in light or electrical signal generated when the biomolecules pass through the nanopores.

    MEASURING REAGENT AND ANALYSIS DEVICE FOR ANALYZING BIOPOLYMER
    7.
    发明申请
    MEASURING REAGENT AND ANALYSIS DEVICE FOR ANALYZING BIOPOLYMER 审中-公开

    公开(公告)号：US20180335417A1

    公开(公告)日：2018-11-22

    申请号：US15777326

    申请日：2016-10-20

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Yusuke GOTO ,  Takahide YOKOI

    IPC: G01N33/487 ,  G01N27/447

    CPC classification number: C12M1/00 ,  G01N15/1031 ,  G01N15/12 ,  G01N33/483 ,  G01N2015/0038

    Abstract: An object of the present invention is to solve inhibition of biopolymer measurement in a nanopore, which involves three-dimensional conformation of a biopolymer containing a nucleic acid. The present invention provides a device for analyzing a biopolymer containing a nucleic acid, the device including: an array device including a plurality of thin film parts having a nanopore; a single common container and a plurality of individual containers capable of storing a measurement solution which is brought into contact with the thin films; and individual electrodes respectively provided in the plurality of individual containers, wherein: the measurement solution is introduced into each of the individual containers and the common container so as to be brought into contact with the thin films; and the measurement solution has a pH equal to or greater than pKa of a guanine base and contains cesium ions as electrolyte cations.

    METHOD FOR TREATING BIOMOLECULES AND METHOD FOR ANALYZING BIOMOLECULES
    8.
    发明申请
    METHOD FOR TREATING BIOMOLECULES AND METHOD FOR ANALYZING BIOMOLECULES 审中-公开

    公开(公告)号：US20200041483A1

    公开(公告)日：2020-02-06

    申请号：US16340995

    申请日：2016-10-20

    Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

    Inventor： Michiru FUJIOKA ,  Yusuke GOTO

    IPC: G01N33/487 ,  G01N27/447 ,  C12Q1/6869

    Abstract: The purpose of the present invention is to provide a method for treating biomolecules and a method for analyzing biomolecules with which it is possible to effectively suppress the clog of nanopores. The present invention is a method for treating biomolecules for analysis in which nanopores are used, wherein the method includes a step for preparing a sample solution that includes ammonium cations represented by a prescribed formula and biomolecules in which at least a portion of the higher-order structure has been fused.

    Ion-Selective Electrode
    9.
    发明申请
    Ion-Selective Electrode 有权
    离子选择电极

    公开(公告)号：US20160223486A1

    公开(公告)日：2016-08-04

    申请号：US15021400

    申请日：2014-07-28

    Applicant: Hitachi High-Technologies Corporation

    Inventor： Yu ISHIGE ,  Masao KAMAHORI ,  Tetsuyoshi ONO ,  Yusuke GOTO

    IPC: G01N27/333

    CPC classification number: G01N27/3335 ,  G01N27/308 ,  G01N27/333

    Abstract: To enhance the potential stability of a solid-electrode-type ion-selective electrode and reduce individual variations, the present invention is provided with an ion-sensitive membrane adapted to be in contact with a measurement solution, a mixture of graphite and liquid oil that is in contact with the ion-sensitive membrane, and a conductor that is in contact with the mixture of graphite and liquid oil.

    Abstract translation: 为了提高固体电极型离子选择性电极的潜在稳定性并减少个体差异，本发明提供了一种适于与测量溶液接触的离子敏感膜，石墨和液体油的混合物， 与离子敏感膜接触，以及与石墨和液体油的混合物接触的导体。

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