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公开(公告)号：US07211417B2
公开(公告)日：2007-05-01
申请号：US10833645
申请日：2004-04-28
IPC分类号： A61K31/496 , C12P17/16 , C12N1/12 , C12N1/20 , C07D401/06
CPC分类号： C07D401/06 , C12P17/165 , C12R1/29
摘要： This invention relates to a new antibiotic designated P175-A, to production of fermentation of Micromonospora echinospora NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic esters and ethers of P175-A.
摘要翻译： 本发明涉及一种名为P175-A的新型抗生素，用于生产小型单孢菌NRRL 30633的发酵，从粗溶液中回收和浓缩的方法，以及P175-A的纯化和半合成酯和醚的方法。
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2.发明授权Substantially pure glycopeptide antibiotics AC-98-1 ; AC-98-2; AC-98-3; AC-98-4 and AC-98-5 有权基本上纯的糖肽抗生素AC-98-1; AC-98-2; AC-98-3; AC-98-4和AC-98-5公开(公告)号：US07696164B2
公开(公告)日：2010-04-13
申请号：US11638225
申请日：2006-12-13
申请人： Guy Thomas Carter , Haiyin He
发明人： Guy Thomas Carter , Haiyin He
CPC分类号： C07H15/203 , A61K31/395 , A61K38/00 , C07H19/04 , C07K9/008 , C12P19/28
摘要： The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus.
摘要翻译： 本发明提供了新的基本上纯的抗生素，其命名为来自微生物吸水链霉菌的AC-98-1，AC-98-2，AC-98-3，AC-98-4和AC-98-5。
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公开(公告)号：US07129266B2
公开(公告)日：2006-10-31
申请号：US10735953
申请日：2003-12-15
申请人： Haiyin He , Hui Yang , Ramunas Bigelis
发明人： Haiyin He , Hui Yang , Ramunas Bigelis
IPC分类号： A61K31/4015 , C07D207/18
CPC分类号： C07D491/08
摘要： The invention relates to a new antibiotic designated Cyan426-A, to its production by fermentation, to methods for its recovery and concentration from the crude solutions, and to a process for its purification and to semisynthetic ethers of Cyan426-A, Cyan426-A-ethers.
摘要翻译： 本发明涉及一种称为Cyan426-A的新型抗生素，其通过发酵生产，其从粗溶液中回收和浓缩的方法，以及Cyan426-A，Cyan426-A的纯化和半合成醚的方法， 醚类。
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4.发明申请ANTIBIOTICS CYAN-416 A, CYAN-416 B, CYAN-416 C, CYAN-416 D AND CYAN-416 E, AND ESTER DERIVATIVES OF CYAN-416 B 失效抗生素CYAN-416 A，CYAN-416 B，CYAN-416 C，CYAN-416 D和CYAN-416 E，以及CYAN-416 B的酯衍生物公开(公告)号：US20060100277A1
公开(公告)日：2006-05-11
申请号：US11303801
申请日：2005-12-16
申请人： Haiyin He , Ramunas Bigelis
发明人： Haiyin He , Ramunas Bigelis
IPC分类号： A61K31/225 , C07C69/616
CPC分类号： C07C69/94 , C07C2603/90 , C12P7/22 , C12P7/62
摘要： The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
摘要翻译： 本发明涉及通过Acremonium sp的发酵，将Cyan-416A，Cyan 416B，Cyan-416C，Cyan-416D和Cyan-416E称为新生抗生素。 NRRL 30631用于从粗溶液中回收和浓缩的方法，以及Cyan-416B的纯化和半合成醚的方法。
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公开(公告)号：US07022873B2
公开(公告)日：2006-04-04
申请号：US10736425
申请日：2003-12-15
申请人： Haiyin He , Ramunas Bigelis
发明人： Haiyin He , Ramunas Bigelis
CPC分类号： C07C69/94 , C07C2603/90 , C12P7/22 , C12P7/62
摘要： The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
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公开(公告)号：US06964860B2
公开(公告)日：2005-11-15
申请号：US10131847
申请日：2002-04-25
申请人： Darren Robert Abbanat , Arthur Emery Bailey , Valerie Sue Bernan , Michael Greenstein , Jason Arnold Lotvin , Mark Edward Ruppen , Alan Gordon Sutherland , Haiyin He
发明人： Darren Robert Abbanat , Arthur Emery Bailey , Valerie Sue Bernan , Michael Greenstein , Jason Arnold Lotvin , Mark Edward Ruppen , Alan Gordon Sutherland , Haiyin He
CPC分类号： C07H15/203 , C07H19/04 , C07K9/008 , C12P19/28
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
摘要翻译： 本发明提供下式的化合物其中R 1，R 2，R 3，R 4，R 4， R 5，R 6a，R 6b，R 6c，R 6d，R SUP， > 6e和R＆lt; 7＆gt;在本说明书中定义。 这些化合物可用作抗生素。
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公开(公告)号：US20080274959A1
公开(公告)日：2008-11-06
申请号：US11794068
申请日：2005-12-16
申请人： Bradley A. Haltli , Haiyin He , Ying Huang , Sridhar Krishna Rabindran , Jiang Wu , Min He
发明人： Bradley A. Haltli , Haiyin He , Ying Huang , Sridhar Krishna Rabindran , Jiang Wu , Min He
IPC分类号： A61K38/16 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/15 , C12P21/00 , C07H17/08 , C07K14/37 , G01N33/566 , C12N1/14 , G01N33/53 , A61P35/00
CPC分类号： C12N15/52
摘要： The present invention provides a chromoprotein produced by Actinomadura sp. 21G792, as well as amino acid and nucleic acid sequences of the apoprotein component of the chromoprotein and of components of the biosynthetic pathway for the chromophore. The present invention is useful for developing pharmaceutical and treating diseases such as cancer or bacterial infections.
摘要翻译： 本发明提供由放线菌属（Actinomadura sp。）生产的色素蛋白 21G792，以及发色蛋白的脱辅基蛋白组分的氨基酸和核酸序列以及发色团的生物合成途径的组分。 本发明可用于开发药物和治疗诸如癌症或细菌感染的疾病。
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8.发明授权Antibiotics Cyan-416 A, Cyan-416 B, Cyan-416 C, Cyan-416 D and Cyan-416 E, and ester derivatives of Cyan-416 B 失效抗生素Cyan-416 A，Cyan-416 B，Cyan-416 C，Cyan-416 D和Cyan-416 E，以及Cyan-416 B的酯衍生物公开(公告)号：US07078556B2
公开(公告)日：2006-07-18
申请号：US11303801
申请日：2005-12-16
申请人： Haiyin He , Ramunas Bigelis
发明人： Haiyin He , Ramunas Bigelis
CPC分类号： C07C69/94 , C07C2603/90 , C12P7/22 , C12P7/62
摘要： The invention relates to new antibiotics designated Cyan-416A, Cyan 416B, Cyan-416C, Cyan-416D and Cyan-416E to their production by fermentation of Acremonium sp. NRRL 30631 to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic ethers of Cyan-416B.
摘要翻译： 本发明涉及通过Acremonium sp的发酵，将Cyan-416A，Cyan 416B，Cyan-416C，Cyan-416D和Cyan-416E称为新生抗生素。 NRRL 30631用于从粗溶液中回收和浓缩的方法，以及Cyan-416B的纯化和半合成醚的方法。
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公开(公告)号：US06914045B2
公开(公告)日：2005-07-05
申请号：US10131890
申请日：2002-04-25
申请人： Darren Robert Abbanat , Valerie Sue Bernan , Russell George Dushin , Michael Greenstein , Haiyin He , Stanley Albert Lang , Howard Newman , Subas Sakya , Phaik-Eng Sum , Alan Gordon Sutherland , Ting-Zhong Wang , Jason Arnold Lotvin , Mark Edward Ruppen , Arthur Emergy Bailey , Ping Cai , Bo Shen , Fangming Kong
发明人： Darren Robert Abbanat , Valerie Sue Bernan , Russell George Dushin , Michael Greenstein , Haiyin He , Stanley Albert Lang , Howard Newman , Subas Sakya , Phaik-Eng Sum , Alan Gordon Sutherland , Ting-Zhong Wang , Jason Arnold Lotvin , Mark Edward Ruppen , Arthur Emergy Bailey , Ping Cai , Bo Shen , Fangming Kong
IPC分类号： A61K38/00 , C07H15/203 , C07H19/04 , C07K9/00
CPC分类号： C07H15/203 , A61K38/00 , C07H19/04 , C07K9/008
摘要： The invention provides compounds of formula Wherein R1, R2, R3, R4, R5, R6a, R6b, R6c, R6d, R6e and R7 are defined in the specification. These compounds are useful as antibiotic agents.
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公开(公告)号：US6034124A
公开(公告)日：2000-03-07
申请号：US212554
申请日：1998-12-16
申请人： Jo Handelsman , Laura Silo-Suh , Jon Clardy , Haiyin He
发明人： Jo Handelsman , Laura Silo-Suh , Jon Clardy , Haiyin He
IPC分类号： C12P7/26 , A01N47/28 , A01N63/00 , A01N63/02 , A61K35/74 , C07C275/16 , C12P1/04 , C12P13/02 , C12P19/26 , C12R1/085 , C12N1/20
CPC分类号： A01N63/00 , A01N47/28 , A01N63/02 , C07C275/16 , C12P1/04 , C12P13/02 , C12P19/26 , C12R1/085
摘要： A biocontrol bacteria, Bacillus cereus ATCC 53522, has been found to naturally synthesize two antibiotics, here designated zwittermicin A and antibiotic B. Zwittermicin A is a 396 dalton linear aminopolyol, a class of metabolite previously unknown in B. cereus. Antibiotic B is an aminoglycoside. Both antibiotics exhibit inhibitory activity on many fungal and bacterial pathogens.
摘要翻译： 已经发现生物控制细菌，蜡状芽孢杆菌ATCC 53522天然地合成了两种抗生素，这里指定了两性霉素A和抗生素B.两性霉素A是396道尔顿线性氨基多酚，一种以前在蜡样芽孢杆菌中未知的代谢物。 抗生素B是一种氨基糖苷类。 两种抗生素都对许多真菌和细菌病原体表现出抑制活性。
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