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1.发明授权Amino acid racemase having low substrate specificity and process for producing racemic amino acid 有权具有低底物特异性的氨基酸消旋酶和用于生产外消旋氨基酸的方法公开(公告)号：US07247466B2
公开(公告)日：2007-07-24
申请号：US10506152
申请日：2003-02-28
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译： 本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收 来自水介质的外消旋氨基酸。
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2.发明申请Low-substrate-specific amino acid racemase and process for producing racemic amino acid 失效低底物特异性氨基酸消旋酶及其制备外消旋氨基酸的方法公开(公告)号：US20090226999A1
公开(公告)日：2009-09-10
申请号：US11808186
申请日：2007-06-07
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译： 本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收 来自水介质的外消旋氨基酸。
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3.发明申请Amino acid racemase having low substrate specificity and process for producing racemic amino acid 有权具有低底物特异性的氨基酸消旋酶和用于生产外消旋氨基酸的方法公开(公告)号：US20050095670A1
公开(公告)日：2005-05-05
申请号：US10506152
申请日：2003-02-28
IPC分类号： C12N1/15 , C12N1/19 , C12N1/21 , C12N9/90 , C12N15/61 , C12P13/04 , C07H21/04 , C12N15/74 , C12P21/06
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译： 本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收 来自水介质的外消旋氨基酸。
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4.发明授权Low-substrate-specific amino acid racemase and process for producing racemic amino acid 失效低底物特异性氨基酸消旋酶及其制备外消旋氨基酸的方法公开(公告)号：US07666653B2
公开(公告)日：2010-02-23
申请号：US11808186
申请日：2007-06-07
摘要： The present invention provides a protein having low-substrate-specific amino acid racemase activity; DNA encoding the protein; a recombinant DNA comprising the DNA; a transformant carrying the recombinant DNA; a process for producing the protein by using the transformant; and a process for producing a racemic amino acid which comprises allowing a culture of the transformant or a treated matter thereof as an enzyme source and an amino acid to be present in an aqueous medium to racemize the amino acid in the aqueous medium, and recovering the racemic amino acid from the aqueous medium.
摘要翻译： 本发明提供了具有低底物特异性氨基酸消旋酶活性的蛋白质; 编码蛋白质的DNA; 包含DNA的重组DNA; 携带重组DNA的转化体; 通过使用转化体生产蛋白质的方法; 以及制备外消旋氨基酸的方法，其包括使转化体或其处理物质的培养物作为酶源，并且氨基酸存在于水性介质中以使水性介质中的氨基酸外消旋化，并回收 来自水介质的外消旋氨基酸。
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公开(公告)号：US20070128687A1
公开(公告)日：2007-06-07
申请号：US10580554
申请日：2004-11-26
CPC分类号： C12P21/02
摘要： The present invention provides a process for producing a dipeptide which comprises: allowing an enzyme source and a diketopiperazine wherein one or two kinds of α-amino acids are condensed with each other to be present in an aqueous medium, said enzyme source being a culture of a microorganism having the ability to produce a dipeptide from a diketopiperazine wherein two kinds of α-amino acids are condensed with each other or a treated matter of the culture; allowing the dipeptide to form and accumulate in the aqueous medium; and recovering the dipeptide from the aqueous medium (provided that the case in which the diketopiperazine is a diketopiperazine wherein aspartic acid and phenylalanine are condensed with each other and the dipeptide is aspartylphenylalanine is excluded).
摘要翻译： 本发明提供一种生产二肽的方法，其包括：允许其中一种或两种α-氨基酸彼此缩合以存在于水性介质中的酶源和二酮哌嗪，所述酶源是 具有从二酮哌嗪产生二肽的能力的微生物，其中两种α-氨基酸彼此缩合或培养物的处理物质; 允许二肽在水性介质中形成和积聚; 并从水性介质中回收二肽（条件是二酮哌嗪为二酮哌嗪的情况，其中天冬氨酸和苯丙氨酸彼此缩合，二肽为天冬氨酰苯丙氨酸）。
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公开(公告)号：US07186532B2
公开(公告)日：2007-03-06
申请号：US10415107
申请日：2001-10-29
CPC分类号： C12R1/19 , C12P13/06 , C12P41/001
摘要： The present invention relates to: a process for producing D-serine wherein a microbial cell which is modified to have a higher L-serine deaminase activity than Escherichia coli DH5α strain, a culture of said cell, or a processed product thereof is brought into contact with DL-serine in a DL-serine-containing medium to decompose L-serine, and the remaining D-serine is recovered from the medium; and a microorganism used for this production process. D-serine is a useful compound as a synthetic intermediate for useful medicaments such as D-cycloserine.
摘要翻译： 本发明涉及：生产D-丝氨酸的方法，其中将经修饰以具有比大肠杆菌DH5α菌株更高的L-丝氨酸脱氨酶活性，所述细胞培养物或其加工产物的微生物细胞接触 在DL-丝氨酸培养基中用DL-丝氨酸分解L-丝氨酸，从培养基中回收剩余的D-丝氨酸; 和用于该生产过程的微生物。 D-丝氨酸是有用的药物如D-环丝氨酸作为合成中间体的有用化合物。
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公开(公告)号：US08257943B2
公开(公告)日：2012-09-04
申请号：US11165226
申请日：2005-06-24
CPC分类号： C12N9/93 , C07K5/06 , C07K14/34 , C12N9/1229 , C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.
摘要翻译： 本发明提供了使用磷酸盐供体，选自腺苷-5'-磷酸，腺苷-5'-二磷酸和腺苷-5'-三磷酸的物质制备二肽或二肽衍生物的方法，其中一种或 更多种类的氨基酸或氨基酸衍生物，作为酶源，具有多磷酸激酶活性的蛋白质，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质，以及具有ATP活性的蛋白质 依赖性地形成来自一种或多种氨基酸或氨基酸衍生物的二肽或二肽衍生物，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质。
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公开(公告)号：US20050287627A1
公开(公告)日：2005-12-29
申请号：US11165226
申请日：2005-06-24
CPC分类号： C12N9/93 , C07K5/06 , C07K14/34 , C12N9/1229 , C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.
摘要翻译： 本发明提供了使用磷酸盐供体，选自腺苷-5'-磷酸，腺苷-5'-二磷酸和腺苷-5'-三磷酸的物质制备二肽或二肽衍生物的方法，其中一种或 更多种类的氨基酸或氨基酸衍生物，作为酶源，具有多磷酸激酶活性的蛋白质，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质，以及具有ATP活性的蛋白质 依赖性地形成来自一种或多种氨基酸或氨基酸衍生物的二肽或二肽衍生物，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质。
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公开(公告)号：US20120258490A1
公开(公告)日：2012-10-11
申请号：US13430937
申请日：2012-03-27
CPC分类号： C12N9/93 , C07K5/06 , C07K14/34 , C12N9/1229 , C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.
摘要翻译： 本发明提供了使用磷酸盐供体，选自腺苷-5'-磷酸，腺苷-5'-二磷酸和腺苷-5'-三磷酸的物质制备二肽或二肽衍生物的方法，其中一种或 更多种类的氨基酸或氨基酸衍生物，作为酶源，具有多磷酸激酶活性的蛋白质，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质，以及具有ATP活性的蛋白质 依赖性地形成来自一种或多种氨基酸或氨基酸衍生物的二肽或二肽衍生物，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质。
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公开(公告)号：US08709752B2
公开(公告)日：2014-04-29
申请号：US13430937
申请日：2012-03-27
CPC分类号： C12N9/93 , C07K5/06 , C07K14/34 , C12N9/1229 , C12P21/02
摘要： The present invention provides a process for producing a dipeptide or a dipeptide derivative using a phosphate donor, a substance selected from the group consisting of adenosine-5′-monophosphate, adenosine-5′-diphosphate and adenosine-5′-triphosphate, one or more kinds of amino acids or amino acid derivatives, and as enzyme sources, a protein having polyphosphate kinase activity, or a culture of cells having the ability to produce the protein or a treated matter of the culture, and a protein having the activity to ATP-dependently form the dipeptide or dipeptide derivative from one or more kinds of amino acids or amino acid derivatives, or a culture of cells having the ability to produce the protein or a treated matter of the culture.
摘要翻译： 本发明提供了使用磷酸盐供体，选自腺苷-5'-磷酸，腺苷-5'-二磷酸和腺苷-5'-三磷酸的物质制备二肽或二肽衍生物的方法，其中一种或 更多种类的氨基酸或氨基酸衍生物，作为酶源，具有多磷酸激酶活性的蛋白质，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质，以及具有ATP活性的蛋白质 依赖性地形成来自一种或多种氨基酸或氨基酸衍生物的二肽或二肽衍生物，或具有产生蛋白质的能力的细胞培养物或培养物的处理物质。
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