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公开(公告)号：US20120071328A1
公开(公告)日：2012-03-22
申请号：US13216893
申请日：2011-08-24
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译： 本发明提供了用于分析核酸样品中靶序列的集合的新颖方法和试剂盒。 在富集包括靶序列集合的片段子集的条件下扩增样品。 本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。
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公开(公告)号：US20080070796A1
公开(公告)日：2008-03-20
申请号：US11874858
申请日：2007-10-18
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译： 本发明提供了用于分析核酸样品中靶序列的集合的新颖方法和试剂盒。 在富集包括靶序列集合的片段子集的条件下扩增样品。 本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。
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公开(公告)号：US07297778B2
公开(公告)日：2007-11-20
申请号：US10264945
申请日：2002-10-04
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译： 本发明提供了用于分析核酸样品中靶序列的集合的新颖方法和试剂盒。 在富集包括靶序列集合的片段子集的条件下扩增样品。 本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。
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公开(公告)号：US08679758B2
公开(公告)日：2014-03-25
申请号：US13568111
申请日：2012-08-06
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译： 本发明提供了用于分析核酸样品中靶序列的集合的新方法和试剂盒。 在富集包括靶序列集合的片段子集的条件下扩增样品。 本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。
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公开(公告)号：US08029999B2
公开(公告)日：2011-10-04
申请号：US11874858
申请日：2007-10-18
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译： 本发明提供了用于分析核酸样品中靶序列的集合的新颖方法和试剂盒。 在富集包括靶序列集合的片段子集的条件下扩增样品。 本发明进一步提供了通过与阵列杂交来分析上述样品，其可以被特别设计成询问用于特定特征的靶序列的收集，例如存在或不存在一个或多个多态性。
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公开(公告)号：US20130137583A1
公开(公告)日：2013-05-30
申请号：US13568111
申请日：2012-08-06
申请人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
发明人： Hajime Matsuzaki , Xing Su , Sean Walsh , Giulia Kennedy , Rui Mei
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6806 , C12Q1/6809 , C12Q1/683 , C12Q1/6837 , C12Q1/6844 , C12Q2600/156
摘要： The presently claimed invention provides for novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
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公开(公告)号：US20070065816A1
公开(公告)日：2007-03-22
申请号：US10442021
申请日：2003-05-19
申请人： Shoulian Dong , Keith Jones , Giulia Kennedy , WeiWei Liu , Hajime Matsuzaki , Michael Shapero
发明人： Shoulian Dong , Keith Jones , Giulia Kennedy , WeiWei Liu , Hajime Matsuzaki , Michael Shapero
CPC分类号： C12Q1/6809 , C12Q1/6837 , C12Q2600/156
摘要： Novel methods and kits for analyzing a collection of target sequences in a nucleic acid sample are provided. A reduced complexity sample is generated and then analyzed. A sample is amplified under conditions that enrich for a subset of fragments that includes a collection of target sequences. The invention further provides for analysis of the above sample. Analysis may be by hybridization to an array, which may be specifically designed to interrogate the collection of target sequences for particular characteristics, such as, for example, the presence or absence of one or more polymorphisms.
摘要翻译： 提供了用于分析核酸样品中靶序列集合的新方法和试剂盒。 生成复杂度降低的样本，然后进行分析。 在富集包括靶序列集合的片段子集的条件下扩增样品。 本发明还提供了上述样品的分析。 分析可以是与阵列杂交，其可以被特别设计成询问用于特定特征的靶序列的收集，例如一个或多个多态性的存在或不存在。
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公开(公告)号：US20110319273A1
公开(公告)日：2011-12-29
申请号：US13222851
申请日：2011-08-31
申请人： Giulia Kennedy
发明人： Giulia Kennedy
IPC分类号： C40B20/00
CPC分类号： C12N15/1072 , C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2565/501
摘要： Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to an array designed to interrogate individual alleles. Genes whose transcription products are present in amounts that vary from expected are candidates for allelic imbalance, imprinting and imprinting errors.
摘要翻译： 提供了用于鉴定印迹基因的方法。 在另一个实施方案中，提供了用于鉴定和分析其表达显示等位基因不平衡的基因的方法。 从作为两个或更多等位基因存在于基因组中的基因转录的表达产物可以通过与设计用于询问单个等位基因的阵列的杂交来区分。 其转录产物存在的量与预期不同的基因是等位基因不平衡，印记和印记错误的候选者。
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公开(公告)号：US20090156522A1
公开(公告)日：2009-06-18
申请号：US11929866
申请日：2007-10-30
申请人： Giulia Kennedy
发明人： Giulia Kennedy
IPC分类号： A61K31/7052 , C12Q1/68 , A61P35/00
CPC分类号： C07K14/47
摘要： The present invention provides the art with the DNA coding sequences of polynucleotides that are up-or-down-regulated in cancer and dysplasia. These polynucleotides and encoded proteins or polypeptides can be used in the diagnosis or identification of cancer and dysplasia. Inhibitors of the up-regulated polynucleotides and proteins can decrease the abnormality of cancer and dysplasia. Enhancing the expression of down-regulated polynucleotides or introducing down-regulated proteins to cells can decrease the growth and/or abnormal characteristics of cancer and dysplasia.
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公开(公告)号：US20060292626A1
公开(公告)日：2006-12-28
申请号：US11511198
申请日：2006-08-28
申请人： Giulia Kennedy
发明人： Giulia Kennedy
IPC分类号： C12Q1/68
CPC分类号： C12N15/1072 , C12Q1/6827 , C12Q1/6883 , C12Q1/6886 , C12Q2600/158 , C12Q2565/501
摘要： Methods are provided for identification of genes that are imprinted. In another embodiment methods are provided for identification and analysis of genes whose expression shows allelic imbalance. The expression products transcribed from genes that are present in the genome as two or more alleles may be distinguished by hybridization to an array designed to interrogate individual alleles. Genes whose transcription products are present in amounts that vary from expected are candidates for allelic imbalance, imprinting and imprinting errors.
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