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公开(公告)号:US20080227788A9
公开(公告)日:2008-09-18
申请号:US10965182
申请日:2004-10-14
申请人: Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
发明人: Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
IPC分类号: A61K31/498 , C07D487/04
CPC分类号: C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
摘要翻译: 式I化合物及其药学上可接受的盐,其中Q 1和R 1在本文中定义,抑制IGF-1R酶,并且可用于治疗和/或预防 通过抑制酪氨酸激酶对治疗作出反应的各种疾病和病症。
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公开(公告)号:US20060084654A1
公开(公告)日:2006-04-20
申请号:US10965182
申请日:2004-10-14
申请人: Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
发明人: Patricia Beck , Cara Cesario , Matthew Cox , Han-Qing Dong , Kenneth Foreman , Mark Mulvihill , Anthony Nigro , Lydia Saroglou , Arno Steinig , Yingchuan Sun , Qinghua Weng , Douglas Werner , Robin Wilkes , Jonathan Williams
IPC分类号: A61K31/498 , C07D487/04
CPC分类号: C07D487/04
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein Q1 and R1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of various diseases and conditions that respond to treatment by inhibition of tyrosine kinases.
摘要翻译: 式I化合物及其药学上可接受的盐,其中Q 1和R 1在本文中定义,抑制IGF-1R酶,并且可用于治疗和/或预防 通过抑制酪氨酸激酶对治疗作出反应的各种疾病和病症。
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公开(公告)号:US20060009645A1
公开(公告)日:2006-01-12
申请号:US10889520
申请日:2004-07-12
申请人: Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Beck , Arlindo Castelhano
发明人: Vanessa Smith , Anthony Nigro , Mark Mulvihill , Cara Cesario , Patricia Beck , Arlindo Castelhano
IPC分类号: C07D249/08 , C07D233/61
CPC分类号: C07D233/64
摘要: Compounds of the formula and pharmaceutically acceptable salts thereof, wherein n1, n2, n3, n4, G1, Q1, Z, R1, R2, R3, R4a, R4b, R5a, and R5b are defined herein, inhibit the cytochrome P450RAI enzyme and are useful for the treatment and/or prevention of various diseases and conditions which respond to treatment by retinoids and by naturally occurring retinoic acid.
摘要翻译: 下式的化合物及其药学上可接受的盐,其中n 1,n 2,n 3,n 4,G 1,Q 1,Z,R 1 R 2,R 3,R 4,R 4a,R 4b,R 5a, 本文定义的R 5b是抑制细胞色素P 450 RAI酶,并且可用于治疗和/或预防响应于维甲酸和天然的治疗的各种疾病和病症 发生视黄酸。
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公开(公告)号:US20060226016A1
公开(公告)日:2006-10-12
申请号:US11420764
申请日:2006-05-28
IPC分类号: C25D5/02
摘要: Low cost methods for fabricating microneedles are disclosed. According to one embodiment, the fabrication method includes the steps of: providing a substrate; forming a metal-containing seed layer on the top surface of the substrate; forming a nonconductive pattern on a portion of the seed layer; plating a first metal on the seed layer and over the edge of the nonconductive pattern to create a micromold with an opening that exposes a portion of the nonconductive pattern; plating a second metal onto the micromold to form a microneedle in the opening; separating the micromold with the microneedle formed therein from the seed layer and the nonconductive pattern; and selectively etching the micromold so as to release the microneedle. In another embodiment, the micromold is not required. The method according to this embodiment includes: forming a recess with an apex in a substrate; forming a seed layer on the substrate; forming a nonconductive pattern on a portion of the seed layer that is on a sidewall surface of the recess; plating an electrically conductive material over the seed layer and over the edge of the nonconductive pattern to form a plated layer with an opening that exposes a portion of the nonconductive pattern; and separating the plated layer from the seed layer and the nonconductive pattern to release a hollow microneedle with an offset opening.
摘要翻译: 公开了制造微针的低成本方法。 根据一个实施例,制造方法包括以下步骤:提供衬底; 在所述基板的顶表面上形成含金属的种子层; 在种子层的一部分上形成非导电图案; 在种子层上和非导电图案的边缘上镀覆第一金属以产生具有露出非导电图案的一部分的开口的微型金属; 将第二金属镀在微型玻璃上以在开口中形成微针; 用形成在其中的微针从种子层和非导电图案分离微型金属; 并选择性地蚀刻微型金属以便释放微针。 在另一个实施例中,不需要微型金属。 根据该实施例的方法包括:在基板中形成具有顶点的凹部; 在所述基板上形成种子层; 在所述种子层的位于所述凹部的侧壁表面上的部分上形成非导电图案; 在种子层上和非导电图案的边缘上镀覆导电材料以形成具有暴露非导电图案的一部分的开口的镀层; 并且将电镀层与种子层和非导电图案分离以释放具有偏移开口的中空微针。
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公开(公告)号:US20060280996A1
公开(公告)日:2006-12-14
申请号:US11151096
申请日:2005-06-13
申请人: Laurie Mittelstadt , Patricia Beck , Yoocharn Jeon , Alfred Pan
发明人: Laurie Mittelstadt , Patricia Beck , Yoocharn Jeon , Alfred Pan
CPC分类号: H01M4/8615 , H01M4/861 , H01M8/1004
摘要: An electrode is disclosed. The electrode includes a substrate having macropores therein. A barrier support layer, established on the substrate, has micropores therein. The macropores and at least some of the micropores are substantially lined with an electrolyte layer. A catalyst is in ionic contact with the electrolyte layer. A current collector is in electrical contact with the catalyst. A barrier layer is established on the barrier support layer and is electrically isolated from the current collector.
摘要翻译: 公开了一种电极。 电极包括其中具有大孔的基板。 建立在基板上的阻挡支撑层在其中具有微孔。 大孔和至少一些微孔基本上衬有电解质层。 催化剂与电解质层离子接触。 集电器与催化剂电接触。 阻挡层建立在阻挡层支撑层上,并与集电器电隔离。
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公开(公告)号:US20060016516A1
公开(公告)日:2006-01-26
申请号:US10896182
申请日:2004-07-21
申请人: Patricia Beck , Sean Zhang
发明人: Patricia Beck , Sean Zhang
CPC分类号: G11B7/244 , C08G61/02 , C08G61/10 , C08G61/123 , C08G73/18 , C08G73/22 , C08J3/24 , G02F1/15 , G11B7/245 , G11B7/246 , G11B7/249 , G11B7/25 , Y10T428/1005 , Y10T428/1009 , Y10T428/1041 , Y10T428/1082 , Y10T428/1157 , Y10T428/2809
摘要: Various embodiments of the present invention are directed to methods for manufacturing complex, anisotropic materials with desirable properties for information storage, processing, and display. Certain of these methods involve employing a magnetic field during manufacture to induce desired orientations of precursors, subunits, and/or molecular subassemblies. The applied magnetic field steers the precursors, subunits, and/or molecular subassemblies into desirable orientations while the precursors, subunits, and/or molecular subassemblies are assembled or self-assemble into a complex, anisotropic material. One embodiment of the present invention is a class of new, complex, well-ordered, network-like materials that include a ferromagnetic-material-based framework in which organic and/or organometallic compounds are organized. The ferromagnetic-molecule-based framework provides a scaffold for assembling the stable, precisely separated layers of organic and/or organometallic compounds and maintaining the layers of organic and/or organometallic compounds in well-ordered, anisotropic arrangements. Additional embodiments of the present invention are directed to methods for manufacturing the new ferromagnetic-molecule-based, network-like materials.
摘要翻译: 本发明的各种实施方案涉及用于制造具有用于信息存储,处理和显示的所需特性的复杂的各向异性材料的方法。 这些方法中的某些涉及在制造过程中采用磁场来诱导前体,亚基和/或分子子组件的所需取向。 施加的磁场将前体,亚基和/或分子子组件转向所需的取向,同时将前体,亚基和/或分子子组件组装或自组装成复杂的各向异性材料。 本发明的一个实施方案是一类新的,复杂的,有序的网状材料,其包括其中组织有机和/或有机金属化合物的基于铁磁材料的框架。 基于铁磁分子的框架提供了用于组装稳定且精确分离的有机和/或有机金属化合物层的支架,并且将有机和/或有机金属化合物的层维持在有秩序的各向异性布置中。 本发明的另外的实施方案涉及用于制造新的基于铁磁分子的网络状材料的方法。
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公开(公告)号:US20050164412A1
公开(公告)日:2005-07-28
申请号:US10995608
申请日:2004-11-22
申请人: Patricia Beck , Douglas Ohlberg , Duncan Stewart , Zhiyong Li
发明人: Patricia Beck , Douglas Ohlberg , Duncan Stewart , Zhiyong Li
CPC分类号: H01L27/28 , G11C13/02 , H01L2924/0002 , H01L2924/00
摘要: A method for tailoring at least portions of an exposed non-planar layered surface of a conductive layer formed on a substrate having a first surface roughness to provide the exposed surface with a second surface roughness. The method includes: forming the conductive layer on the substrate; and tailoring at least portions of the exposed surface of the conductive layer in a plasma to at least smooth the exposed surface of the conductive layer, whereby the second surface roughness is essentially the same as the first surface roughness.
摘要翻译: 一种用于调整形成在具有第一表面粗糙度的基底上的导电层的暴露的非平面层状表面的至少一部分以提供具有第二表面粗糙度的暴露表面的方法。 该方法包括:在基板上形成导电层; 以及在等离子体中定制导电层的暴露表面的至少部分,以至少平滑导电层的暴露表面,由此第二表面粗糙度基本上与第一表面粗糙度相同。
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公开(公告)号:US20050026427A1
公开(公告)日:2005-02-03
申请号:US10930062
申请日:2004-08-30
申请人: Patricia Beck , Douglas Ohlberg , Duncan Stewart , Zhiyong Li
发明人: Patricia Beck , Douglas Ohlberg , Duncan Stewart , Zhiyong Li
CPC分类号: H01L27/28 , G11C13/02 , H01L2924/0002 , H01L2924/00
摘要: A method is provided for fabricating molecular electronic devices comprising at least a bottom electrode and a molecular switch film on the bottom electrode. The method includes forming the bottom electrode by a process including: cleaning portions of the substrate where the bottom electrode is to be deposited; pre-sputtering the portions; depositing a conductive layer on at least the portions; and cleaning the top surface of the conductive layer. Advantageously, the conductive electrode properties include: low or controlled oxide formation (or possibly passivated), high melting point, high bulk modulus, and low diffusion. Smooth deposited film surfaces are compatible with Langmuir-Blodgett molecular film deposition. Tailored surfaces are further useful for SAM deposition. The metallic nature gives high conductivity connection to molecules. Barrier layers may be added to the device stack, i.e., Al2O3 over the conductive layer.
摘要翻译: 提供了一种用于制造分子电子器件的方法,该分子电子器件至少包括底部电极和底部电极上的分子开关膜。 该方法包括通过以下工艺形成底部电极,该方法包括:清洗要沉积底部电极的衬底的部分; 预溅射部分; 在至少部分上沉积导电层; 并清洁导电层的顶表面。 有利地,导电电极的性质包括:低或受控的氧化物形成(或可能钝化),高熔点,高体积弹性模量和低扩散。 光滑的沉积膜表面与Langmuir-Blodgett分子膜沉积相容。 定制的表面对于SAM沉积是更有用的。 金属性质使分子具有高导电性。 阻挡层可以被添加到器件堆叠,即在导电层上的Al 2 O 3。
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公开(公告)号:US20050242339A1
公开(公告)日:2005-11-03
申请号:US10835943
申请日:2004-04-29
申请人: Patricia Beck
发明人: Patricia Beck
IPC分类号: G01N27/07 , G01Q60/00 , H01L21/4763 , H01L47/00
CPC分类号: G01N27/07 , B82Y30/00 , Y10S977/836
摘要: An apparatus for transverse characterization of materials includes a lower pattern of contacts, separated by spacings, a material, and an upper pattern of a multiplicity of contacts, separated by spacings differing from the spacings of the lower pattern. The transverse characterization method includes receiving lower pattern of a multiplicity of contacts, separated by spacings along a surface, with a material above the surface, successively placing an upper contact near the upper surface of the material in an upper pattern of locations separated by spacings differing from the spacings of the lower pattern, measuring the characteristics between the upper contact and one or more contacts of the lower pattern and evaluating the measured characteristics to previous measurements, wherein the evaluation provides the transverse characterization.
摘要翻译: 用于材料的横向表征的装置包括通过间隔分开的下部接触图案,材料和由与下部图案的间隔不同的间隔分开的多个触点的上部图案。 横向表征方法包括接收由表面间隔分开的多个接触部分的下部图案,其中在表面上方的材料连续地将上接触部分靠近材料的上表面放置在由不同间隔分开的位置的上部图案中 从下部图案的间隔,测量上部接触和下部图案的一个或多个触点之间的特性并将测量的特性评估为先前的测量,其中评估提供横向表征。
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公开(公告)号:US20050068668A1
公开(公告)日:2005-03-31
申请号:US10696824
申请日:2003-10-30
申请人: Patricia Beck , Paul Poorman , George Clifford , Richard Henze
发明人: Patricia Beck , Paul Poorman , George Clifford , Richard Henze
CPC分类号: G11B5/187 , G11B5/1871 , G11B5/4893 , G11B5/584 , G11B15/62 , Y10T29/49032 , Y10T29/49043 , Y10T29/49048 , Y10T29/49055 , Y10T29/4906 , Y10T29/49789 , Y10T29/49798
摘要: A batch fabrication technique is described that increases the manufacturing efficiency of servo write heads and also improves servo pattern definition for fine features, while reducing tape and head wear. Multiple heads are fabricated as a batch from one or more ferrite wafers. A nominally flat, large wafer surface and a contour suitable for uniform photoresist application and planar photolithography permit fine servo pattern definition. A rounded leading edge on the head creates an air bearing to reduce wear of the tape and of the head. Moreover, any head wear occurs at the leading edge rather than in the region of the head where the servo pattern is formed. The servo write head may have a substantially planar head surface. A leading edge is disposed adjacent to the head surface such that the tape contacts the leading edge before passing over the head surface. The leading edge is rounded to form an air bearing between the head surface and the tape. A rounded trailing edge may be disposed adjacent to the head surface such that the tape passes over the trailing edge after passing over the head surface. The head may be formed from an upper ferrite wafer having a non-magnetic spacer. Non-magnetic material is photolithographically defined to produce gaps above the spacer. The non-magnetic material may be photoresist, semiconductor materials, glass, metal or the like. The material may even be removed later to leave air gaps. The non-magnetic material forms a region where the field loops out to intersect the passing tape, thereby transferring a magnetic pattern to tape. Additionally, a lower ferrite wafer may be mated to the upper ferrite wafer to complete a magnetic circuit around the gaps. The upper or lower ferrite wafer may have a channel through which an inductive winding passes. Multiple heads may be formed through batch processing of the upper and lower ferrite wafers.
摘要翻译: 描述了一种批量制造技术,其提高了伺服写入头的制造效率,并且还改善了精细特征的伺服模式定义,同时减少了磁带和磁头磨损。 多个头部从一个或多个铁氧体晶片制成批次。 标称平坦,大的晶片表面和适用于均匀光刻胶应用和平面光刻的轮廓允许精细的伺服模式定义。 头部圆角的前缘形成一个空气轴承,以减少磁带和磁头的磨损。 此外,任何头部磨损发生在前缘而不是在形成伺服图案的头部的区域中。 伺服写入头可以具有基本平坦的头表面。 前缘邻近头表面设置,使得带在通过头表面之前接触前缘。 前缘是圆形的,以在头表面和带之间形成空气轴承。 圆形的后缘可以邻近头部表面设置,使得带在经过头表面之后越过后缘。 头部可以由具有非磁性间隔物的上部铁氧体晶片形成。 非磁性材料被光刻定义以在间隔物上方产生间隙。 非磁性材料可以是光致抗蚀剂,半导体材料,玻璃,金属等。 材料甚至可以稍后移除以留下空隙。 非磁性材料形成区域,其中磁场循环出来以与通过的磁带相交,从而将磁性图案转印到磁带上。 此外,下部铁氧体晶片可以与上部铁氧体晶片配合,以在该间隙周围形成磁路。 上或下铁素体晶片可以具有感应绕组通过的通道。 可以通过上下铁素体晶片的批量处理形成多个头。
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