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58 条记录 (耗时 0.047 秒)

    Labelled adrenomedullin derivatives and their use for imaging and therapy
    6.
    发明申请
    Labelled adrenomedullin derivatives and their use for imaging and therapy 有权
    标记的肾上腺髓质素衍生物及其用于成像和治疗

    公开(公告)号：US20090028790A1

    公开(公告)日：2009-01-29

    申请号：US12149989

    申请日：2008-05-12

    申请人： Jocelyn Dupuis ,  Alain Fournier

    发明人： Jocelyn Dupuis ,  Alain Fournier

    IPC分类号： A61K51/00 ,  C07K14/00 ,  A61K49/00

    CPC分类号： A61K51/088 ,  C07K14/575

    摘要： The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.

    摘要翻译： 本发明涉及包含与至少一种活性剂螯合或以其它方式结合的肾上腺髓质素肽或其片段的肾上腺髓质素衍生物。 活性剂的实例包括顺磁元件，放射性元素和纤维蛋白溶解剂等。 顺磁剂具有通过磁共振成像（MRI）相对容易地显示的分布。 取决于活性剂中包含的特定元素，放射性剂可用于成像和辐射辐射。 纤维蛋白溶解剂主要递送到特定器官，例如肺，允许通过允许局部输送纤维蛋白溶解剂来大大改善溶栓治疗的特异性和功效，从而降低治疗中的大出血的风险 器官。 如果器官是肺，则可用纤维蛋白溶解剂治疗的病理学的非限制性实例是肺栓塞。

    Process for the protection of flexible silicone membranes, particularly in the case of molding by resin transfer
    9.
    发明授权
    Process for the protection of flexible silicone membranes, particularly in the case of molding by resin transfer 有权
    用于保护柔性硅氧烷膜的方法，特别是在通过树脂转移成型的情况下

    公开(公告)号：US06790531B2

    公开(公告)日：2004-09-14

    申请号：US10095082

    申请日：2002-03-12

    申请人： Alain Fournier

    发明人： Alain Fournier

    IPC分类号： B32B2520

    CPC分类号： C08J7/047 ,  B29C33/64 ,  B29C43/3642 ,  B29K2083/00 ,  B29K2995/0067 ,  B29K2995/0069 ,  B32B25/20 ,  C08J2383/04 ,  C08J2483/00 ,  Y10S528/901 ,  Y10T428/31663

    摘要： Process for treating a flexible bi-constituent self-demolding silicone membrane used as a counterform particularly for resin transfer molding. The membrane is coated with a thin layer of at least one monoconstituent silicone which is a polysiloxane cross-linkable at ambient temperature in the presence of the moisture in air. The polysiloxane corresponds to the formula (I): in which: the substituents R3, R4, and R5 are selected from alkyl or aryl radicals, R6 represents an alkyloxy group, an alkenyloxy group, an alcanoyloxy group, an amino group, a ketiminoxy group, an amido group, an aminoxy group.

    摘要翻译： 用于处理柔性双组分自脱模硅酮膜的方法，其特别用于树脂传递模塑。 膜上涂有薄层的至少一种单成分硅酮，它是在空气中存在湿气的情况下可在环境温度下交联的聚硅氧烷。 聚硅氧烷对应于式（I）：其中：取代基R 3，R 4和R 5选自烷基或芳基，R 6表示烷氧基，链烯氧基 氨基酰氧基，氨基，酮亚氨氧基，酰氨基，氨氧基。

    FEBP1 Protein: vector, host cells and method for making FEBP1 protein
    10.
    发明授权
    FEBP1 Protein: vector, host cells and method for making FEBP1 protein 失效
    FEBP1蛋白：载体，宿主细胞和制备FEBP1蛋白的方法

    公开(公告)号：US06696273B2

    公开(公告)日：2004-02-24

    申请号：US09780996

    申请日：2001-02-09

    申请人： Isabelle Maury ,  Luc Mercken ,  Alain Fournier

    发明人： Isabelle Maury ,  Luc Mercken ,  Alain Fournier

    IPC分类号： C12N1511

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention relates to novel compounds and their pharmaceutical or diagnostic use, or use as a pharmacological target. More particularly, the present invention describes the identification of partners of the FE65 protein and the use of these partners, or of any compound which is capable of modulating, at least partially, their interaction with FE65, for regulating the activity of FE65, and in particular the phenomenon of intracellular transport or of endocytosis of the APP.

    摘要翻译： 本发明涉及新化合物及其药物或诊断用途，或用作药理学靶标。 更具体地，本发明描述了鉴定FE65蛋白的配偶体以及这些配偶体或任何能够至少部分调节其与FE65的相互作用以调节FE65活性的化合物的使用，以及 特别是APP的细胞内运输或内吞现象。