公开(公告)号：US08064998B2

公开(公告)日：2011-11-22

申请号：US11863375

申请日：2007-09-28

申请人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/145 ,  A61N1/368 ,  A61N1/3682

摘要： Heart stimulating system for stimulating at least a ventricle of a heart including: stimulation pulse generator adapted to generate stimulation pulses and connected to a ventricular stimulation electrode for delivering stimulation pulses, atrial sensing stage connected to an electrode for picking up potentials inside an atrium and adapted to sense an excitation or contraction of atrial myocardium, ventricular sensing stage connected to an electrode for picking up potentials inside a ventricle and adapted to sense an excitation or contraction of ventricular myocardium, memory for AV-delay values, a control unit adapted to trigger said stimulation pulse generator to generate ventricular stimulation pulses timed based on AV-delay values stored in said memory and to acquire atrioventricular interval samples, and atrioventricular interval timing analyzing unit for receiving atrioventricular interval samples from said control unit and adapted to generate at least one histogram based on said atrioventricular interval samples and analyze said histograms.

摘要翻译： 用于刺激至少一个心脏心室的心脏刺激系统，包括：刺激脉冲发生器，其适于产生刺激脉冲并连接到心室刺激电极以传递刺激脉冲，心房感测级连接到电极，用于拾取心房内的电位并适应 感测心房心肌的激发或收缩，心室感测阶段连接到电极，用于拾取心室内的电位并且适于感测心室心肌的激发或收缩，用于AV延迟值的记忆，适于触发所述 刺激脉冲发生器，以产生基于存储在所述存储器中的AV延迟值定时并获取房室间隔样本的心室刺激脉冲，以及房室间隔定时分析单元，用于从所述控制单元接收房室间隔样本，并适于生成至少一个基于直方图 就说 房室间隔采样并分析所述直方图。

公开(公告)号：US08718751B2

公开(公告)日：2014-05-06

申请号：US11746156

申请日：2007-05-09

申请人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61B5/08 ,  A61B5/04 ,  A61B5/053 ,  A61B5/085

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61B5/0809 ,  A61B5/4818 ,  A61N1/36114 ,  A61N1/36542 ,  A61N1/36585

摘要： A heart monitoring system comprises a ventricular sensing stage sensing excitation or contraction of ventricular myocardium, an activity sensor unit determining a signal reflecting a patient's physical activity, a ventricular impedance or conductance measuring module, said modules comprising a current source unit adapted to provide a sub-threshold excitation current to the myocardium and comprising an impedance or conductance measurement unit for measuring the resulting voltage on said electrode at the myocardium, a signal generator module, a filter module, a memory, a control unit adapted to derive single measures |ΣZ| of magnitude of impedance or conductance change over a preset sample time interval, determine the variability TARVI in the impedance or conductance change, compare this variability and the activity sensor output signal with a threshold and recent history, determine if sleep disturbed breathing (SDB) is present, and log the SDB episode in the memory device.

摘要翻译： 心脏监测系统包括心室感测阶段感测心室心肌的激发或收缩，活动传感器单元确定反映患者身体活动的信号，心室阻抗或电导测量模块，所述模块包括电流源单元，其适于提供子 并且包括用于测量心肌上的所述电极上产生的电压的阻抗或电导测量单元，信号发生器模块，滤波器模块，存储器，适于导出单个测量的控制单元。 Z | 在预设的采样时间间隔内测量阻抗或电导变化的大小，确定阻抗或电导变化中的变异性TARVI，将该变异性和活动传感器输出信号与阈值和最近历史进行比较，确定睡眠扰动呼吸（SDB）是否为 呈现并记录SDB剧集在内存设备中。

公开(公告)号：US20080009910A1

公开(公告)日：2008-01-10

申请号：US11484336

申请日：2006-07-10

申请人： Hannes Kraetschmer ,  Xin Good

发明人： Hannes Kraetschmer ,  Xin Good

IPC分类号： A61N1/00

CPC分类号： A61N1/368 ,  A61N1/3688

摘要： Cardiac pacemaker, having at least one stimulation pulse generator to selectively generate stimulation pulses for delivery to an atrium or to an atrium and a ventricle of a heart in DDD mode, at least one sensing stage adapted to process electrical signals sensed by an atrial and ventricular sensing electrode to detect an atrial or ventricular event and to generate an atrial or ventricular sense signal upon event detection, a control unit connected to the generator and sensing stage and being adapted to trigger the generator in DDD mode, wherein the control unit is adapted to verify proper atrioventricular conduction and to switch from a regular (DDD) mode, wherein scheduled ventricular stimulation pulses having predetermined positive intensity is triggered unless inhibited to a ventricular pulse suppression mode (VPS mode) wherein no ventricular stimulation pulses or ventricular stimulation pulses of sub-threshold intensity are generated as long as proper atrioventricular conduction is verified.

摘要翻译： 心脏起搏器，具有至少一个刺激脉冲发生器，以选择性地产生刺激脉冲，用于递送至DDD模式的心房或心脏的心房和心室，至少一个感测级，适于处理由心房和心室感测的电信号 检测电极以检测心房或心室事件并且在事件检测时产生心房或心室感测信号;控制单元，其连接到所述发生器和感测级，并且适于以DDD模式触发所述发生器，其中所述控制单元适于 验证正常的房室传导并从常规（DDD）模式切换，其中触发具有预定正强度的预定心室刺激脉冲，除非被抑制到心室脉搏抑制模式（V S P S模式），其中无心室 只要适当的房室传导c就产生刺激脉冲或亚阈值强度的心室刺激脉冲 导弹被验证。

公开(公告)号：US07697986B2

公开(公告)日：2010-04-13

申请号：US11484336

申请日：2006-07-10

申请人： Hannes Kraetschmer ,  Xin Good

发明人： Hannes Kraetschmer ,  Xin Good

IPC分类号： A61N1/00

CPC分类号： A61N1/368 ,  A61N1/3688

摘要： Cardiac pacemaker, having at least one stimulation pulse generator to selectively generate stimulation pulses for delivery to an atrium or to an atrium and a ventricle of a heart in DDD mode, at least one sensing stage adapted to process electrical signals sensed by an atrial and ventricular sensing electrode to detect an atrial or ventricular event and to generate an atrial or ventricular sense signal upon event detection, a control unit connected to the generator and sensing stage and being adapted to trigger the generator in DDD mode, wherein the control unit is adapted to verify proper atrioventricular conduction and to switch from a regular (DDD) mode, wherein scheduled ventricular stimulation pulses having predetermined positive intensity is triggered unless inhibited to a ventricular pulse suppression mode (VPS mode) wherein no ventricular stimulation pulses or ventricular stimulation pulses of sub-threshold intensity are generated as long as proper atrioventricular conduction is verified.

摘要翻译： 心脏起搏器，具有至少一个刺激脉冲发生器，以选择性地产生刺激脉冲，用于递送至DDD模式的心房或心脏的心房和心室，至少一个感测级，适于处理由心房和心室感测的电信号 检测电极以检测心房或心室事件并且在事件检测时产生心房或心室感测信号;控制单元，其连接到所述发生器和感测级，并且适于以DDD模式触发所述发生器，其中所述控制单元适于 验证正常的房室传导并从常规（DDD）模式切换，其中触发具有预定正强度的预定心室刺激脉冲，除非被抑制到心室脉冲抑制模式（VPS模式），其中不存在心室刺激脉冲或子室刺激脉冲， 只要适当的房室传导i产生阈值强度 的验证。

公开(公告)号：US20090088814A1

公开(公告)日：2009-04-02

申请号：US11863375

申请日：2007-09-28

申请人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： Xin Good ,  David F. Hastings ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61N1/00

CPC分类号： A61N1/3702 ,  A61B5/0422 ,  A61B5/0452 ,  A61B5/053 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/145 ,  A61N1/368 ,  A61N1/3682

摘要： Heart stimulating system for stimulating at least a ventricle of a heart including: stimulation pulse generator adapted to generate stimulation pulses and connected to a ventricular stimulation electrode for delivering stimulation pulses, atrial sensing stage connected to an electrode for picking up potentials inside an atrium and adapted to sense an excitation or contraction of atrial myocardium, ventricular sensing stage connected to an electrode for picking up potentials inside a ventricle and adapted to sense an excitation or contraction of ventricular myocardium, memory for AV-delay values, a control unit adapted to trigger said stimulation pulse generator to generate ventricular stimulation pulses timed based on AV-delay values stored in said memory and to acquire atrioventricular interval samples, and atrioventricular interval timing analyzing unit for receiving atrioventricular interval samples from said control unit and adapted to generate at least one histogram based on said atrioventricular interval samples and analyze said histograms.

摘要翻译： 用于刺激至少一个心脏心室的心脏刺激系统，包括：刺激脉冲发生器，其适于产生刺激脉冲并连接到心室刺激电极以传递刺激脉冲，心房感测级连接到电极，用于拾取心房内的电位并适应 感测心房心肌的激发或收缩，心室感测阶段连接到电极，用于拾取心室内的电位并且适于感测心室心肌的激发或收缩，用于AV延迟值的记忆，适于触发所述 刺激脉冲发生器，以产生基于存储在所述存储器中的AV延迟值定时并获取房室间隔样本的心室刺激脉冲，以及房室间隔定时分析单元，用于从所述控制单元接收房室间隔样本，并适于生成至少一个基于直方图 就说 房室间隔采样并分析所述直方图。

公开(公告)号：US20070265539A1

公开(公告)日：2007-11-15

申请号：US11746156

申请日：2007-05-09

申请人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

发明人： David F. Hastings ,  Xin Good ,  Hannes Kraetschmer ,  Dirk Muessig

IPC分类号： A61B5/04

CPC分类号： A61N1/36521 ,  A61B5/0535 ,  A61B5/0809 ,  A61B5/4818 ,  A61N1/36114 ,  A61N1/36542 ,  A61N1/36585

摘要： A heart monitoring system comprises a ventricular sensing stage sensing excitation or contraction of ventricular myocardium, an activity sensor unit determining a signal reflecting a patient's physical activity, a ventricular impedance or conductance measuring module, said modules comprising a current source unit adapted to provide a sub-threshold excitation current to the myocardium and comprising an impedance or conductance measurement unit for measuring the resulting voltage on said electrode at the myocardium, a signal generator module, a filter module, a memory, a control unit adapted to derive single measures |ΣZ| of magnitude of impedance or conductance change over a preset sample time interval, determine the variability TARVI in the impedance or conductance change, compare this variability and the activity sensor output signal with a threshold and recent history, determine if sleep disturbed breathing (SDB) is present, and log the SDB episode in the memory device.

摘要翻译： 心脏监测系统包括心室感测阶段感测心室心肌的激发或收缩，活动传感器单元确定反映患者身体活动的信号，心室阻抗或电导测量模块，所述模块包括电流源单元，其适于提供子 包括用于测量心肌上所述电极上产生的电压的阻抗或电导测量单元，信号发生器模块，滤波器模块，存储器，适于导出单个测量的控制单元| SigmaZ | 在预设的采样时间间隔内测量阻抗或电导变化的大小，确定阻抗或电导变化中的变异性TARVI，将该变异性和活动传感器输出信号与阈值和最近历史进行比较，确定睡眠扰动呼吸（SDB）是否为 呈现并记录SDB剧集在内存设备中。

公开(公告)号：US08649864B2

公开(公告)日：2014-02-11

申请号：US11873292

申请日：2007-10-16

申请人： David F. Hastings ,  Xin Good ,  Volker Lang

发明人： David F. Hastings ,  Xin Good ,  Volker Lang

IPC分类号： A61N1/365

CPC分类号： A61N1/362

摘要： An implantable medical device that continuously measures the patient's intracardiac ventricular impedance. Extracts cardiac performance information based on the intracardiac impedance, including amplitude, timing and variability of cardiac contraction function. The device records and analysis trends in the performance information. The device identifies changes, which exceed the selected threshold limits. In the event of an incipient crisis, the device transmits an alert message.

摘要翻译： 可植入的医疗装置，可持续测量患者的心内心室阻抗。 基于心脏内阻抗提取心脏性能信息，包括心脏收缩功能的幅度，时间和变异性。 设备记录和分析性能信息的趋势。 设备识别出超出选定阈值限制的更改。 在发生初期危机的情况下，设备会发送警报消息。

公开(公告)号：US20090099617A1

公开(公告)日：2009-04-16

申请号：US11873292

申请日：2007-10-16

申请人： David F. Hastings ,  Xin Good ,  Volker Lang

发明人： David F. Hastings ,  Xin Good ,  Volker Lang

IPC分类号： A61N1/365

CPC分类号： A61N1/362

摘要： An implantable medical device that continuously measures the patient's intracardiac ventricular impedance. Extracts cardiac performance information based on the intracardiac impedance, including amplitude, timing and variability of cardiac contraction function. The device records and analyses trends in the performance information. The device identifies changes, which exceed the selected threshold limits. In the event of an incipient crisis, the device transmits an alert message.

摘要翻译： 可植入的医疗装置，可持续测量患者的心内心室阻抗。 基于心脏内阻抗提取心脏性能信息，包括心脏收缩功能的幅度，时间和变异性。 设备记录和分析性能信息的趋势。 设备识别出超出选定阈值限制的更改。 在发生初期危机的情况下，设备会发送警报消息。