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    5,6,7,8:Tetrahydrocarbazole-1-carboxylic acid derivatives
    3.
    发明授权
    5,6,7,8:Tetrahydrocarbazole-1-carboxylic acid derivatives 失效
    5,6,7,8：四氢咔唑-1-羧酸衍生物

    公开(公告)号：US4057640A

    公开(公告)日：1977-11-08

    申请号：US683752

    申请日：1976-05-06

    申请人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    发明人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    IPC分类号： A61K31/405 ,  C07D209/88 ,  A61K31/40

    CPC分类号： C07D209/88 ,  A61K31/405

    摘要： Carbazoles of the formula ##STR1## wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, orR.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, andR.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.

    摘要翻译： 其中R 1为羟甲基，烷酰氧基甲基，四唑基，氰基，肟基羰基，氨基羰基，羧基及其盐与生理上可接受的碱，其酯与其生理上可接受的醇和酰胺与生理上可接受的胺，R 2至R 6各自相同 是氢原子，卤素原子，低级烷基，三氟甲基或低级烷氧基，或者R5和R6共同是五元或六元的环状环，而R7是3-8个碳原子的烃，或者当至少一个 R 2至R 6不是氢原子，氢原子，甲基或乙基，并且R 7是氢原子，甲基或乙基的相应化合物，以及5,6,7,8-四氢四硼化物，POSSESS主题抗体 -INFLAMMATORY活动。

    Carbazole derivatives
    4.
    发明授权
    Carbazole derivatives 失效
    咔唑衍生物

    公开(公告)号：US3956295A

    公开(公告)日：1976-05-11

    申请号：US489162

    申请日：1974-07-17

    申请人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    发明人： Helmut Biere ,  Hanns Ahrens ,  Clemens Rufer ,  Eberhard Schroder ,  Henning Koch

    IPC分类号： A61K31/405 ,  C07D209/88 ,  C07D209/82

    CPC分类号： C07D209/88 ,  A61K31/405 ,  Y10S514/887

    摘要： Carbazoles of the formula ##SPC1##Wherein R.sub.1 is hydroxymethyl, alkanoyloxymethyl, tetrazolyl, cyano, oximinocarbonyl, aminocarbonyl, carboxyl and salts thereof with physiologically acceptable bases and the esters thereof with physiologically acceptable alcohols and amides thereof with physiologically acceptable amines,R.sub.2 through R.sub.6 each are a hydrogen atom, halogen atom, lower alkyl, trifluoromethyl, or lower alkoxy, orR.sub.5 and R.sub.6 collectively are a five- or six-membered isocyclic ring, andR.sub.7 is a hydrocarbon of 3-8 carbon atoms or, when at least one of the R.sub.2 through R.sub.6 is other than a hydrogen atom, a hydrogen atom, methyl or ethyl,And the corresponding compounds wherein R.sub.7 is a hydrogen atom, methyl or ethyl,And the 5,6,7,8-tetrahydrocarbazoles, possess topical anti-inflammatory activity.

    摘要翻译： 式VIII的咔唑，其中R1是羟甲基，烷酰氧基甲基，四唑基，氰基，肟基羰基，氨基羰基，羧基及其盐与生理上可接受的碱，其酯与其生理上可接受的醇和酰胺与生理上可接受的胺，R2至R6各自为氢 原子，卤素原子，低级烷基，三氟甲基或低级烷氧基，或者R5和R6共同是五元或六元的环状环，并且R 7是3-8个碳原子的烃，或者当R2中的至少一个 通过R6不同于氢原子，氢原子，甲基或乙基，以及其中R7是氢原子，甲基或乙基的相应化合物，以及5,6,7,8-四氢四硼化物，POSSESS局部抗炎活性 。

    1,2-Biguanides
    5.
    发明授权
    1,2-Biguanides 失效
    1,2双胍

    公开(公告)号：US3960949A

    公开(公告)日：1976-06-01

    申请号：US486758

    申请日：1974-07-09

    申请人： Hanns Ahrens ,  Clemens Rufer ,  Helmut Biere ,  Eberhard Schroder ,  Wolfgang Losert ,  Olaf Loge ,  Ekkehard Schillinger

    发明人： Hanns Ahrens ,  Clemens Rufer ,  Helmut Biere ,  Eberhard Schroder ,  Wolfgang Losert ,  Olaf Loge ,  Ekkehard Schillinger

    IPC分类号： C07C279/26 ,  C07C129/16

    CPC分类号： C07C279/26

    摘要： 1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1##With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.2 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; or cycloalkyl of 3-6 carbon atoms, alkoxyalkyl containing a total of 2-12 carbon atoms, or alkoxy of 1-6 atoms; mixtures thereof, and pharmaceutically acceptable acid addition salts thereof, are useful in the treatment of diabetes mellitus.

    摘要翻译： 1,2-取代的式R'1 | R1-NC-NH-C-NH2的平行二亚胺平行平行NNH | R2其中R1是1-12个碳原子的饱和或不饱和的直链或支链烃，未取代或未取代的 被一个或多个氟原子取代; 3-6个碳原子的环烷基; 或下式的芳基或芳烷基：其中N为整数0,1或2且X为氢或卤素; 并且R'1是1-12个碳原子的氢原子或饱和或不饱和的直链或支链烃基; 或者R1和R'1与它们所连接的氮原子一起是含有一个或多个杂原子的杂环; R2是未被取代或被一个或多个氟原子取代的1-12个碳原子的饱和或不饱和的直链或支链烃基; 或3-6个碳原子的环烷基，总共2-12个碳原子的烷氧基烷基或1-6个原子的烷氧基; 其混合物及其药学上可接受的酸加成盐可用于治疗糖尿病。

    Pyrido[2,1-b]quinazolinone derivatives and the preparation and use thereof
    7.
    发明授权
    Pyrido[2,1-b]quinazolinone derivatives and the preparation and use thereof 失效
    吡啶并[2,1-b]喹唑啉酮衍生物及其制备和应用

    公开(公告)号：US4457927A

    公开(公告)日：1984-07-03

    申请号：US452009

    申请日：1982-12-22

    申请人： Helmut Biere ,  Joachim-Friedrich Kapp ,  Irmgard Bottcher

    发明人： Helmut Biere ,  Joachim-Friedrich Kapp ,  Irmgard Bottcher

    IPC分类号： A61K31/505 ,  A61K31/517 ,  A61P25/04 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D209/38 ,  C07D213/61 ,  C07D471/04

    CPC分类号： C07D471/04 ,  C07D209/38 ,  C07D213/61

    摘要： Pyrido[2,1-b]quinazolinones of the formula ##STR1## wherein X is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl, carboxy, carboxy in the form of a salt thereof with a physiologically compatible base, carboxy esterified with a physiologically acceptable alcohol or carboxy amidated with a physiologically acceptable amine;R.sub.1 is hydrogen or methyl; andR.sub.2 through R.sub.5 are independently each hydrogen, halogen, alkyl of 1-4 carbon atoms, trifluoromethyl, carboxy, thiocyano, methylthio, methylsulfinyl, methylsulfonyl, methylsulfonimidoyl or methylsulfonamido with the proviso that two or three of the groups R.sub.2 through R.sub.5 are hydrogen; or a salt thereof with a physiologically acceptable acid or base;possess valuable pharmacological properties.

    摘要翻译： 其中X是氰基的吡啶并[2,1-b]喹唑啉酮，其中X是氰基，羟基酰氨基羰基，氨基甲酰基，5-四唑基，羧基，其盐与生理上相容的碱形式的羧基， 醇或羧基与生理学上可接受的胺酰胺化; R1是氢或甲基; R 2至R 5各自独立地为氢，卤素，1-4个碳原子的烷基，三氟甲基，羧基，硫氰基，甲硫基，甲基亚磺酰基，甲基磺酰基，甲基亚氨基亚氨基或甲基亚磺酰氨基，条件是R2至R5中的两个或三个为氢; 或其盐与生理上可接受的酸或碱反应; 具有宝贵的药理性质。