-
公开(公告)号：US20070208018A1
公开(公告)日：2007-09-06
申请号：US11572007
申请日：2005-07-26
申请人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
发明人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
IPC分类号： A61K31/5377 , A61K31/517 , C07D413/02 , C07D239/92
CPC分类号： C07D409/12 , C07D239/96 , C07D401/12 , C07D403/04
摘要： The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula(I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮衍生物，其中取代基如说明书中所定义，它们的制备，它们作为药物的用途以及含有它们的药物组合物。
-
公开(公告)号：US08299085B2
公开(公告)日：2012-10-30
申请号：US11572007
申请日：2005-07-26
申请人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
发明人： Hans Allgeier , Wolfgang Froestl , Manuel Koller , Henri Mattes , Joachim Nozulak , Silvio Ofner , David Orain , Vittorio Rasetti , Johanne Renaud , Nicolas Soldermann , Philipp Floersheim
IPC分类号： A01N43/54 , A61K31/517
CPC分类号： C07D409/12 , C07D239/96 , C07D401/12 , C07D403/04
摘要： The present invention relates to 1H-Quinazoline-2,4-dione derivatives of formula(I) wherein the substituents are defined as in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮衍生物，其中取代基如说明书中所定义，它们的制备，它们作为药物的用途以及含有它们的药物组合物。
-
3.发明授权1H-quinazoline-2,4-diones processes for their production, pharmaceutical compositions, and treatment for epilepsy 失效1H-喹唑啉-2,4-二酮的制备方法，药物组合物和治疗癫痫公开(公告)号：US08513268B2
公开(公告)日：2013-08-20
申请号：US13192816
申请日：2011-07-28
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
-
4.发明授权Substituted 1H-quinazoline-2,4-diones useful as AMPA receptor ligands 失效可用作AMPA受体配体的取代的1H-喹唑啉-2,4-二酮公开(公告)号：US07655666B2
公开(公告)日：2010-02-02
申请号：US11911040
申请日：2006-04-10
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
-
公开(公告)号：US20110294818A1
公开(公告)日：2011-12-01
申请号：US13192816
申请日：2011-07-28
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517 , C07D403/10 , C07D405/10 , C07D401/10 , C07C229/66 , C07C229/64 , C07D307/16 , C07D309/12 , C07C265/12 , C07D231/12 , C07D249/06 , C07D207/337 , C07C205/57 , C07D237/08 , A61P25/08 , A61P25/18 , C07D239/96
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
-
6.发明授权N-(2,4-dioxo-6-(tetrahydrofuran-2-yl)-7-(trifluoromethyl)-1,4-dihydro-2H-quinazolin-3-yl)methanesulfonamide 失效N-（2,4-二氧代-6-（四氢呋喃-2-基）-7-（三氟甲基）-1,4-二氢-2H-喹唑啉-3-基）甲磺酰胺公开(公告)号：US08012988B2
公开(公告)日：2011-09-06
申请号：US12569402
申请日：2009-09-29
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jörg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/517
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如说明书中所定义，其制备，作为药物的用途，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
-
公开(公告)号：US20140018376A1
公开(公告)日：2014-01-16
申请号：US13502765
申请日：2010-10-20
申请人： Hans Allgeier , Yves Auberson , Thomas Blaettler , David Carcache , Philipp Floersheim , Wolfgang Froestl , Christel Guibourdenche , Hans o Kalkman , Joerg Kallen , Manuel Koller , Kurt Lingenhohl , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud , Christine Strohmaier
发明人： Hans Allgeier , Yves Auberson , Thomas Blaettler , David Carcache , Philipp Floersheim , Wolfgang Froestl , Christel Guibourdenche , Hans o Kalkman , Joerg Kallen , Manuel Koller , Kurt Lingenhohl , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud , Christine Strohmaier
IPC分类号： C07D239/96 , C07D403/04 , C07D405/04
CPC分类号： C07D239/96 , C07D403/04 , C07D405/04
摘要： The invention concerns the use of competitive AMPA receptor antagonists for the treatment, prevention or delay of progression of Rasmussen's encephalitis and/or certain forms of epilepsy.
摘要翻译： 本发明涉及竞争性AMPA受体拮抗剂用于治疗，预防或延缓拉斯穆森脑炎和/或某些形式的癫痫发展的用途。
-
公开(公告)号：US20080153836A1
公开(公告)日：2008-06-26
申请号：US11911040
申请日：2006-04-10
申请人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jorg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
发明人： Hans Allgeier , Yves Auberson , David Carcache , Philipp Floersheim , Christel Guibourdenche , Wolfgang Froestl , Jorg Kallen , Manuel Koller , Henri Mattes , Joachim Nozulak , David Orain , Johanne Renaud
IPC分类号： A61K31/501 , C07D239/72 , A61K31/517 , A61P25/00 , C07D237/06
CPC分类号： C07D239/96 , C07C207/00 , C07C229/56 , C07C229/64 , C07C229/66 , C07C255/18 , C07C265/12 , C07C271/58 , C07D207/337 , C07D231/12 , C07D237/08 , C07D239/26 , C07D241/12 , C07D249/06 , C07D263/32 , C07D307/16 , C07D307/54 , C07D309/12 , C07D401/04 , C07D403/04 , C07D405/04 , C07D413/04
摘要： The present invention relates to 1H-Quinazoline-2,4-diones of formula (I) wherein R1 and R2 are as defined in the specification, their preparation, their use as pharmaceuticals, and pharmaceutical compositions containing them. Further, intermediates for the manufacture of compounds of formula (I) are and combinations comprising compounds of formula (I) are disclosed.
摘要翻译： 本发明涉及式（I）的1H-喹唑啉-2,4-二酮，其中R 1和R 2如本说明书中所定义，它们的制备，它们的 用作药物，以及含有它们的药物组合物。 此外，公开了用于制备式（I）化合物的中间体和包含式（I）化合物的组合。
-
公开(公告)号：US20100179153A1
公开(公告)日：2010-07-15
申请号：US12597100
申请日：2008-04-21
申请人： Henri Mattes , Joachim Nozulak , David Orain , Kumlesh K. Dev
发明人： Henri Mattes , Joachim Nozulak , David Orain , Kumlesh K. Dev
IPC分类号： A61K31/502 , C07D237/32 , C07D217/24 , A61K31/47 , A61P25/00 , A61P37/00
CPC分类号： C07D237/32 , C07D217/24
摘要： The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, b their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方法，b用作药物和包含它们的药物。
-
公开(公告)号：US20100197753A1
公开(公告)日：2010-08-05
申请号：US12601475
申请日：2008-05-20
申请人： Henri Mattes , Joachim Nozulak , David Orain , Kumlesh K. Dev
发明人： Henri Mattes , Joachim Nozulak , David Orain , Kumlesh K. Dev
IPC分类号： A61K31/166 , C07C237/44 , C07D231/12 , C07C231/02 , A61K31/4164
CPC分类号： C07C237/44 , C07C237/30 , C07C2601/08 , C07D231/12 , C07D233/64 , C07D309/12
摘要： The invention relates to novel aromatic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, b their use as medicaments and to medicaments comprising them.
摘要翻译： 本发明涉及下式的新型芳族化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方法，其用作药物和包含它们的药物。
-
-
-
-
-
-
-
-
-
搜索结果
15 条记录 (耗时 0.039 秒)
