公开(公告)号：US06424859B2

公开(公告)日：2002-07-23

申请号：US09334661

申请日：1999-06-17

申请人： Michael Jackson ,  Michael G. Sowa ,  James R. Mansfield ,  Hans H. Eysel ,  Henry H. Mantsch ,  Hani El-Gabalawy ,  Jan M. Canvin

发明人： Michael Jackson ,  Michael G. Sowa ,  James R. Mansfield ,  Hans H. Eysel ,  Henry H. Mantsch ,  Hani El-Gabalawy ,  Jan M. Canvin

IPC分类号： A61B600

CPC分类号： G01N21/49 ,  A61B5/0059 ,  A61B5/4528 ,  A61B5/7267 ,  G01N21/359

摘要： A novel near infrared spectroscopic technique was used to characterize the joints in arthritis with comparison against normal joints. A beam of near infrared light was passed to joints through a fibre optic cable. Scattered light was collected by the same fibre bundle and a spectrum of the joint computed. Multivariate pattern recognition techniques identified regions of the spectrum which allowed discrimination between healthy and affected joints. Linear discriminant analysis resulted in correct classification of 74% of the joints. The high degree of similarity between mean spectra representing the early, late and control groups along with the significant between—subject variability in the data make diagnosis based on visual assessment of the spectra impossible. Linear discriminant analysis was therefore applied to spectra to determine if spectra could be classified by statistical methods as arising from early or late RA. Application of LDA resulted in correct classification of 74% of the joints. Interestingly, the spectral regions in which diagnostic differences were found by the multivariate analysis contain absorption bands related to tissue oxygenation status (oxy and deoxyhaemoglobin) and oxygen utilisation (cytochrome aa3), suggesting that ischaemic changes within the joint are being detected.

摘要翻译： 与正常关节相比，使用新型近红外光谱技术来表征关节炎关节。 一束近红外光通过光缆传递到接头。 散射光被相同的纤维束收集，并计算出关节的光谱。 多变量模式识别技术确定了允许区分健康和受影响关节的频谱区域。 线性判别分析导致74％关节的正确分类。 表示早期，晚期和对照组的平均光谱之间的高度相似性以及数据中显着的受试者间变异性，基于对光谱的视觉评估不可能进行诊断。 因此，将线性判别分析应用于光谱，以确定是否可以通过统计学方法将光谱分类为早期或晚期RA引起的。 LDA的应用导致74％的关节正确分类。 有趣的是，通过多变量分析发现诊断差异的光谱区域包含与组织氧合状态（氧和脱氧血红蛋白）和氧利用（细胞色素aa3）相关的吸收带，表明正在检测到关节内的缺血性变化。

公开(公告)号：US5473160A

公开(公告)日：1995-12-05

申请号：US288321

申请日：1994-08-10

申请人： Hans H. Eysel ,  Michael Jackson ,  Henry H. Mantsch

发明人： Hans H. Eysel ,  Michael Jackson ,  Henry H. Mantsch

IPC分类号： G01N21/35

CPC分类号： G01N21/3577

摘要： Differences in the physical and chemical properties of synovial fluid from healthy and arthritic joints are detected by infrared spectroscopy. A beam of infrared light is directed at a sample of synovial fluid (either in its native form or prepared as a film) and changes in the physical and chemical properties of the fluid being analyzed are detected at one or more wavelengths to determine whether changes in the position, width, absolute intensity, relative intensity or shape of the infrared absorption have occurred which are characteristic of the arthritic condition.

摘要翻译： 通过红外光谱法检测健康关节炎关节滑液的物理化学性质差异。 红外光束被引导到滑液样品（以其天然形式或作为膜制备），并且以一个或多个波长检测待分析的流体的物理和化学性质的变化，以确定是否改变 发生了红外吸收的位置，宽度，绝对强度，相对强度或形状，这是关节炎病症的特征。

公开(公告)号：US06587701B1

公开(公告)日：2003-07-01

申请号：US09402348

申请日：2000-02-17

申请人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

IPC分类号： A61B500

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Tissues remaining below a certain hemoglobin oxygen saturation threshold (oxygen saturation index 6 h) became increasingly dehydrated, eventually becoming visibly necrotic. Tissues above this threshold (oxygen saturation index>1), despite being significantly hypoxic relative to the pre-elevation saturation values, remained viable over the 72 h post-elevation monitoring period. The magnitude of the drop in tissue oxygen saturation, as observed immediately following surgery, correlated with the final clinical outcome of the flap tissue. These results indicate the potential of near infrared spectroscopy and imaging to monitor tissue oxygenation status and assess tissue viability following reconstructive surgery. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 持续低于一定血红蛋白氧饱和度阈值（氧饱和度指数<1）的组织长时间（> 6小时）变得越来越脱水，最终变得明显坏死。 尽管相对于抬高前的饱和度值显着缺氧，但超过这个阈值的组织（氧饱和度指数> 1）在升高后监测期间仍然可行。 手术后立即观察到的组织氧饱和度下降的幅度与瓣组织的最终临床结果相关。 这些结果表明近红外光谱和成像监测组织氧合状态和评估重建手术后组织活力的潜力。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。

公开(公告)号：US5916152A

公开(公告)日：1999-06-29

申请号：US857012

申请日：1997-05-15

申请人： Luis Oppenheimer ,  Henry H. Mantsch ,  Michael G. Sowa ,  Jing Wang

发明人： Luis Oppenheimer ,  Henry H. Mantsch ,  Michael G. Sowa ,  Jing Wang

IPC分类号： G01N33/52 ,  A61B5/00

CPC分类号： G01N33/52

摘要： A spectrophotometric analytical method for lung permeability is described. An exogenous polydispersed macromolecule is administered, and fluid of the patient is evaluated using infrared spectroscopy.

摘要翻译： 描述了肺透过性的分光光度分析方法。 施用外源性多分散大分子，使用红外光谱法评价患者的流体。

公开(公告)号：US20090216098A1

公开(公告)日：2009-08-27

申请号：US12391707

申请日：2009-02-24

申请人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Tissues remaining below a certain hemoglobin oxygen saturation threshold (oxygen saturation index 6 h) became increasingly dehydrated, eventually becoming visibly necrotic. Tissues above this threshold (oxygen saturation index >1), despite being significantly hypoxic relative to the pre-elevation saturation values, remained viable over the 72 h post-elevation monitoring period. The magnitude of the drop in tissue oxygen saturation, as observed immediately following surgery, correlated with the final clinical outcome of the flap tissue. These results indicate the potential of near infrared spectroscopy and imaging to monitor tissue oxygenation status and assess tissue viability following reconstructive surgery. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 持续低于一定血红蛋白氧饱和度阈值（氧饱和度指数<1）的组织长时间（> 6小时）变得越来越脱水，最终变得明显坏死。 尽管相对于抬高前的饱和度值显着缺氧，但超过这个阈值的组织（氧饱和度指数> 1）在升高后监测期间仍然可行。 手术后立即观察到的组织氧饱和度下降的幅度与瓣组织的最终临床结果相关。 这些结果表明近红外光谱和成像监测组织氧合状态和评估重建手术后组织活力的潜力。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。

公开(公告)号：US07022527B2

公开(公告)日：2006-04-04

申请号：US10485413

申请日：2002-09-11

申请人： Kan-Zhi Liu ,  Anthony Shaw ,  Henry H. Mantsch

发明人： Kan-Zhi Liu ,  Anthony Shaw ,  Henry H. Mantsch

IPC分类号： G01N33/92

CPC分类号： G01N33/491 ,  G01N21/35 ,  G01N21/359 ,  G01N33/92 ,  G01N2201/1293

摘要： A method of simultaneously determining the concentrations of cardiovascular risk markers selected from the group consisting of High Density Lipoprotein cholesterol (HDL-C), Low Density Lipoprotein cholesterol (LDL-C), total cholesterol, triglycerides and oxidized LDL using infra-red and/or near infrared light is described.

摘要翻译： 选自高密度脂蛋白胆固醇（HDL-C），低密度脂蛋白胆固醇（LDL-C），总胆固醇，甘油三酯和氧化低密度脂蛋白的心血管风险标志物浓度的方法，其使用红外和/ 或近红外光。

公开(公告)号：US08060188B2

公开(公告)日：2011-11-15

申请号：US12391707

申请日：2009-02-24

申请人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. R. Sowa ,  Henry H. Mantsch

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。

公开(公告)号：US07860554B2

公开(公告)日：2010-12-28

申请号：US10182128

申请日：2001-01-26

申请人： Lorenzo Leonardi ,  Jerl Payette ,  Michael G. Sowa ,  Mark Hewko ,  Bernhard J. Schattka ,  Henry H. Mantsch

发明人： Lorenzo Leonardi ,  Jerl Payette ,  Michael G. Sowa ,  Mark Hewko ,  Bernhard J. Schattka ,  Henry H. Mantsch

IPC分类号： A61B5/00

CPC分类号： A61B5/445 ,  A61B5/0059 ,  A61B5/0075 ,  A61B5/1455 ,  A61B2562/0233 ,  A61B2562/0242 ,  A61B2562/043

摘要： A non-invasive method of characterizing burn injuries using near infrared spectroscopy is described. In the method, a beam of light is emitted into the burnt tissue portion at two or more different tissue depths. The spectra are then compared using multivariate analysis to determine diagnostic regions of the spectra. This information is used to categorize the burn. In some cases, the diagnostic regions correspond to wavelengths related to the hemodynamics of the tissue portion. The spectra can also be repeated over time, thereby allowing trends and changes in the spectra to be measured. This data is in turn used to categorize the burn as either a superficial burn, partial thickness burn, deep partial burn or a full thickness burn. Once the burn has been categorized, the clinician can intervene as needed to treat the burn.

摘要翻译： 描述了使用近红外光谱表征烧伤的非侵入性方法。 在该方法中，光束在两个或多个不同的组织深度处被发射到烧伤组织部分。 然后使用多变量分析比较光谱，以确定光谱的诊断区域。 此信息用于对刻录进行分类。 在一些情况下，诊断区域对应于与组织部分的血液动力学相关的波长。 光谱也可以随时间重复，从而允许测量光谱的趋势和变化。 这些数据反过来用于将烧伤分为表面烧伤，部分厚度烧伤，深部分烧伤或全厚度烧伤。 一旦烧伤被分类，临床医生可以根据需要进行干预以治疗烧伤。

公开(公告)号：US07729747B2

公开(公告)日：2010-06-01

申请号：US10319838

申请日：2002-12-16

申请人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

发明人： Miroslaw F. Stranc ,  Michael G. Sowa ,  Henry H. Mantsch

IPC分类号： A61B5/00

CPC分类号： A61B5/14551 ,  A61B5/0261 ,  A61B5/413 ,  A61B5/7264

摘要： Prolonged and severe tissue hypoxia results in tissue necrosis in pedicled flaps. We demonstrate the potential of near-infrared spectroscopy for predicting viability of compromised tissue portions. This approach clearly identifies tissue regions with low oxygen supply, and also the severity of this challenge, in a rapid and non-invasive manner, with a high degree of reproducibility. Early, nonsubjective detection of poor tissue oxygenation following surgery increases the likelihood that intervention aimed at saving the tissue will be successful.

摘要翻译： 长时间和严重的组织缺氧导致腓肠肌瓣组织坏死。 我们展示了近红外光谱学预测受损组织部分活力的潜力。 该方法以高度重现性清楚地以快速和非侵入的方式识别低氧供应的组织区域，以及该挑战的严重性。 早期的非主观检测手术后组织氧合不良增加了旨在挽救组织的干预成功的可能性。